Abstract: ［Abstract］Diabetic nephropathy（DN）is one of the severe chronic complications of diabetes, and has become an important contributing factor of end-stage renal disease and increased mortality of diabetes. DN pathogenesis is complicated，involving many factors working together. Regenerative medicine based on stem cells for the treatment of DN brings new hope. The mechanism of mesenchymal stem cells（MSCs）improving DN development get more and more attention，in this paper，we will talk about MSCs in improving DN through paracrine effect，hope it will provide the new mentality for the treatment of DN.