OPRM1基因DNA甲基化在物质依赖中的研究进展

杨晓佩; 姜焰凌; 阮冶; 张寿勋; 赵斐; 张柠; 夏生; 钟树荣

OPRM1基因DNA甲基化在物质依赖中的研究进展

1. 昆明医科大学法医学院
2. 昆明医科大学附属精神卫生中心
3. 昆明医科大学司法鉴定中心

基金项目:

基金：国家自然科学基金资助项目 (81660232、81000577); 云南省科技厅-昆明医科大学联合专项基金资助项目 (2015FB011); 昆明医科大学大学生创新性试验计划项目 (CX201654); 云南省大学生创新创业训练计划项目 (601162023);

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出版历程
- 收稿日期: 2016-10-10

Progress on DNA Methylation of OPRM1 Gene in Substance Dependence

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摘要

摘要: 物质依赖是指个体强烈地或不可自制地反复渴求滥用某种药物.尽管心理上知道经常、多次服用这种物质会给自己带来不良后果, 但仍然无法控制自己的行为.常使用的物质包括酒、海洛因、摇头丸、K粉、冰毒、大麻等.物质成瘾的调控模式由社会、环境、生物学等因素相互交织构成.其中生物学因素主要通过药物作用于中枢神经系统, 产生强大的奖赏效应.OPRM1是大多数物质依赖产生躯体依赖、戒断症状等成瘾行为的物质基础之一.研究表明OPRM1启动子高甲基化可以增加酒精依赖综合征和其他物质依赖的患病风险.就OPRM1基因的DNA甲基化与物质依赖的关联性作一综述.
- 物质依赖 /
- μ-阿片受体1基因 /
- DNA甲基化
Abstract: Substance dependence mainly refers to the behavior of an individual who is strongly or repeatedly craving a drug abuse.Though psychologically aware that often or repeated doses of the substance lead to adverse consequences, but one still cannot control his own behavior.Often used substances are wine, heroin, ecstasy, K powder, methamphetamine and marijuana, etc.Regulation and control of substance addiction is by interwoven constitute of the society, environment, biology and other factors.The biological factors mainly work through the action of a drug on the central nervous system, resulting in a strong reward effect.The OPRM1 gene encoding mu opioid receptors plays a bridge role Regulation and control mode of substance addiction is by interwoven constitute of the society, environment, biology and other factors.Researches have shown that methylation of OPRM1 promoter can increase the risk of alcohol dependence syndrome and other drug dependence.This paper makes a review on the correlation between DNA methylation of OPRM1 gene and substance dependence.
- Substance dependence /
- OPRM1 gene /
- DNA methylation

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参考文献(24)

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