Beclin 1、LC3在恶性纤维组织细胞瘤中的表达
Expression of Beclin 1 and LC3 in Malignant Fibrous Histiocytoma
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摘要: 目的 研究自噬蛋白Beclin 1、LC3在恶性纤维组织细胞瘤的表达.方法 选取云南省肿瘤医院2011年11月至2014年10月经手术切除的MFH组织标本, 应用免疫组织化学SP方法检测恶性纤维组织细胞瘤组织中Beclin 1、LC3蛋白表达情况.结果 在本组21例标本中Beclin 1、LC3基因表达均显著升高, P<0.05.结论 Beclin 1、LC3在恶性纤维组织细胞瘤组织中呈高表达, 并且两者间显著相关, 可能与恶性纤维组织细胞瘤的发生及发展密切相关.Abstract: Objective To reserch the expression of Beclin 1 and LC3 in malignant fibrous histiocytoma.Methods The sp immunohistochemical method was taken in 21 cases with Malignant fibrous histiocytoma, then the expression of Beclin 1, LC3 was detected.Results The expression levels of Beclin 1 and LC3 were significantly high in all cases.Conclusion Beclin 1 and LC3 might play a role in the occurrence and development of malignant fibrous histiocytoma.
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Key words:
- Malignant fibrous histiocytoma /
- Autophagy /
- Beclin 1 /
- LC3
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