透析患者微炎症状态与血脂代谢及钙磷代谢的相关性
Correlation of Serum Lipid Metabolism, Calcium and Phosphorus Metabolism in Hemodialysis Patients with Micro Inflammatory State
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摘要: 目的 透析患者微炎症状态与血脂代谢及钙、磷代谢的相关性分析, 并探讨其临床意义.方法 尿毒症腹膜透析患者31例 (腹膜透析组:PD组) , 持续血液透析患者31例 (血液透析组:HD组) , 同期健康体检者18例 (对照组) , 采用ELISA法检测各组血清超敏C反应蛋白 (hs-CRP) , 全自动生化分析仪检测血肌酐、尿素氮, 总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯、血钙、血磷、甲状旁腺激素等, 并对结果进行分析.结果 与正常对照组相比, HD组患者及PD组患者的血hs-CRP升高, 差异有统计学意义 (P<0.05) ;总胆固醇、血磷、血甲状旁腺激素及钙磷乘积较正常对照组升高, 差异均有统计学意义 (P<0.05) ;甘油三脂及低密度脂蛋白胆固醇与正常对照相比差异无统计学意义 (P>0.05) .而HD组患者与PD组患者血脂代谢、钙磷代谢差异无统计学意义 (P>0.05) .PD组患者甘油三脂与hs-CRP具有正相关性 (r=0.36, P<0.05) , 其余血脂及钙磷代谢指标与hs-CRP均无明显相关性 (P>0.05) ;HD组患者血脂代谢及钙磷代谢指标与hs-CRP均无明显相关性 (P>0.05) .结论 长期透析患者存在微炎症状态, 同时伴有血脂代谢紊乱及钙磷代谢异常, 但炎症因子hs-CRP与血脂及钙磷代谢没有显著相关性.Abstract: Objective To study the correlation of micro inflammation state with serum lipid metabolism, calcium and phosphorus metabolism in hemodialysis patients and its clinical significance.Methods We selected31 uremic peritoneal dialysis patients (peritoneal dialysis group:PD group) , 31 continuous hemodialysis patients (hemodialysis group:HD group) , and 18 healthy subjects (control group) .ELISA method was used to detect serum level of high sensitive C reactive protein (hs-CRP) .Automatic biochemical analyzer was used to detect the serum creatinine, urea nitrogen, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, triglyceride, serum calcium, phosphorus, parathyroid hormone, and the results were analyzed.Results Compared with the normal control group, HD group and PD group patients had higher blood hs-CRP, the difference was statistically significant (P<0.05) .Total cholesterol, serum phosphorus, parathyroid hormoneand calcium phosphate product of patients in HD and PD groups were higher than those of the control group, the difference was statistically significant (P <0.05) .There was no statistically significant difference between the normal control group and the HD group or the PD group in low density lipoprotein cholesterol and triglyceride (P>0.05) .PD group of patients had a positive correlation between triglyceride and hs-CRP (r=0.36, P<0.05) , there was no significant correlation between other indexes serum lipid, calcium phosphorus metabolism and hs-CRP (P>0.05) .Conclusions Micro inflammatory state exsists in patients with chronic dialysis, accompanied by abnormal metabolism of serum lipids and calcium and phosphorus metabolism, but hs-CRP is not significantly correlated with lipid, calcium and phosphorus metabolism.
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