塞来昔布在治疗压力性尿失禁中的疗效及安全性

李江; 刘上; 陈伟康; 张伟; 方克伟

塞来昔布在治疗压力性尿失禁中的疗效及安全性

昆明医科大学第二附属医院泌尿外科

基金项目:

基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2015FA007); 昆明医科大学科技创新团队建设基金资助项目 (CXTD201618) ;昆明医科大学研究生创新基金资助项目 (2016s104);

计量
- 文章访问数: 1688
- HTML全文浏览量: 589
- PDF下载量: 137
- 被引次数: 0
出版历程
- 收稿日期: 2016-10-20

The Effectiveness and Safety of Celecoxib in Treatment of Female Stress Urinary Incontinence

Funds:

摘要

摘要: 目的评价塞来昔布胶囊 (西乐葆) 治疗压力性尿失禁的疗效、安全性及并探讨可能机制.方法2014年1月至2015年12月昆明医科大学第二附属医院门诊单纯性女性压力性尿失禁患者80例作为实验组:口服塞来昔布胶囊200 mg, Bid, 共3月;另80例单纯性女性压力性尿失禁患者为对照组:服用安慰剂 (医用淀粉) 1粒/次, 2次/d, 共3月.2组均辅以行为治疗、盆底功能锻炼.治疗3月后随访, 以尿垫实验及生活质量量表评估疗效.结果实验组与对照组在年龄、病程上差异无统计学意义 (P>0.05) ;实验组疗效优于对照组, 在尿垫实验方面, 实验组漏尿量明显少于对照组, 在生活质量评分量表 (QOL-36-SF) 方面, 不论是生理维度还是心理维度的得分, 实验组明显高于对照组 (P<0.05) .总的效果, 实验组显效21例 (26.3%) , 有效56例 (70%) , 无效3例 (3.8%) , 有效率为96.3%.对照组显效15例 (18.8%) , 有效56例 (70%) , 无效9例 (11.2%) , 有效率为88.6%, 2组疗效比较, 差异有统计学意义 (P<0.05) ;实验组及对照组均无明显不良反应, 亦无自行停药者.结论服用塞来昔布胶囊可改善压力性尿失禁症状, 药物具有较好安全性和耐受性.
- 环氧化酶2抑制剂 /
- 压力性尿失禁 /
- 药物治疗 /
- 逼尿肌 /
- 尿道括约肌 /
- 排尿反射
Abstract: Objective To explore the effectiveness, safety and the possible mechanism of Celecoxib Capsules (Celebrex) in treatment of female stress urinary incontinence.Methods From January 2014 to December 2015, 80 female patients with stress urinary incontinence, from the outpatient department of our hospital, were selected in experimental group, who took celecoxib orally 200 mg, Bid for 3 months.The other 80 female patients with stress urinary incontinence were selected in control group, who took placebo (medical starch) orally 1 piece, Bid for 3 months.The two groups of patients were treated with behavioral therapy and functional exercise of pelvic floor.Both groups of patients were assessed with the urine pad test and quality of life scale 3months later.The study was approved by the Institutional Review Board of the second Hospital of Kunming Medical University and followed the principles expressed in the Declaration of Helsinki.The written informed consent was obtained from every patient.Results The difference between the experimental group and the control group in the age, the course of disease had no statistical significance (P>0.05) .The effectiveness of experimental goup was better than the controlled group.The urine volume in experimental group is less than that in control group in urine pad test.And the score of experimental goup in QOL-36-SF was higher than that of control group both in physical dimension and the psychological dimension.The overall effective rate was 96.3% in experimental group [21 (26.3%) cases were improved markedly, 56 (70%) patients improved, 3 (3.8%) patients was failed] and88.6% in control group [15 (18.8%) cases were improved markedly, 56 (70%) patients improved, 3 (3.8%) patients was failed].Tthe difference has statistical significance (P<0.05) .No obvious side effects were observed in both groups and no one stooped the treatment by herself.Conclusion Celecoxib can attenuate the symptoms of female stress urinary incontinence, and has the good safety and tolerability.
- Cyclooxygenase 2 inhibitor (COX-2) /
- Stress urinary incontinence (SUI) /
- Drug therapy /
- Detrusor /
- Urethral sphincter /
- Micturition reflex

HTML全文

参考文献(22)

[1]	[1]HAYLEN B T, DE RIDDER D, FREEMAN R M, et al.An International Urogynecological Association (IUGA) /International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction[J].International Urogynecology Journal, 2010, 21 (1) :5-26.
[2]高继学, 贺晓龙, 李义, 等.延安市女性压力性尿失禁流行病学调查分析[J].昆明医科大学学报, 2015, 36 (4) :31-33.
[3]方克伟, 刘晋宏.女性UI及POP的流行病学研究进展[J].国际泌尿系统杂志, 2011, 31 (4) :501-504.
[4]	[4]DMOCHOWSKI R R, BLAIVAS J M, GORMLEY E A, et al.Update of AUA guideline on the surgical management of female stress urinary incontinence[J].Journal of Urology, 2010, 183 (5) :1906-1914.
[5]	[5]MALALLAH M A, ALSHAIJI T F.Pharmacological treatment of pure stress urinary incontinence:A narrative review[J].International Urogynecology Journal, 2015, 26 (4) :477-485.
[6]杨智明.压力性尿失禁大鼠模型的建立及NOS、COX2、P38的检测[D].昆明:昆明医科大学硕士学位论文, 2015.
[7]张磊, 徐德忠, 黄久仪, 等.SF-36量表中文版的应用及分级截断点选择的研究[J].中华流行病学杂态, 2004, 25 (1) :69-73.
[8]郝明, 善辉.压力尿失禁解剖学发生机制的研究进展[J].2012, 25 (1) :97-99.
[9]	[9]MARENTETTE J O, HURST R E, MCHOWAT J.Impaired expression of prostaglandin E2 (PGE2) synthesis and degradation enzymes during differentiation of immortalized urothelial cells from patients with interstitial cystitis/painful bladder syndrome[J].PLo S One, 2015, 10 (5) :e129466.
[10]	[10]RAHNAMA IMS, KOEVERINGE GAV, KERREBROECK PEV, et al.The effect of indomethacin on the muscarinic induced contractions in the isolated normal guinea pig urinary bladder[J].BMC Urology, 2013, 13 (1) :1-9.
[11]	[11]JUAN Y S, LEE Y L, LONG C Y, et al.Translocation of NF-κB and Expression of Cyclooxygenase-2 Are Enhanced by Ketamine-Induced Ulcerative Cystitis in Rat Bladder[J].European Urology Supplements, 2015, 185 (8) :2269-2285.
[12]	[12]RIBEIRO ASF, FERNANDES V S, MART I NEZ M P, et al.Neuronal and Non-Neuronal Bradykinin Receptors Are Involved in the Contraction and/or Relaxation to the Pig Bladder Neck Smooth Muscle[J].Neurourology and Urodynamics, 2014, 33 (5) :558-565.
[13]	[13]TANAKA I, NAGASE K, TANASE K, et al.Improvement in neurogenic detrusor overactivity by peripheral C fiber's suppression with cyclooxygenase inhibitors[J].Journal of Urology, 2010, 183 (183) :786-792.
[14]	[14]YIP C, KWOK E, SASSANI F, et al.A biomechanical model to assess the contribution of pelvic musculature weakness to the development of stress urinary incontinence[J].Computer Methods in Biomechanics&Biomedical Engineering, 2014, 17 (2) :163-176.
[15]	[15]YOSHIMURA N, KAIHO Y, MIYAZATO M, et al.Therapeutic receptor targets for lower urinary tract dysfunction[J].Naunyn-Schmiedeberg's Archives of Pharmacology, 2008, 377 (4) :437-448.
[16]	[16]WEINHOLD P, GRATZKE C T, STIEF C, et al.TRPA1receptor induced relaxation of the human urethra involves TRPV1 and cannabinoid receptor mediated signals, and cyclooxygenase activation[J].Journal of Urology, 2010, 183 (5) :2070-2076.
[17]	[17]REILLY C A, JOHANSEN M E, LANZA D L, et al.Calcium-dependent and independent mechanisms of capsaicin receptor (TRPV1) -mediated cytokine production and cell death in human bronchial epithelial cells[J].Journal of Biochemical&Molecular Toxicology, 2005, 19 (4) :266-275.
[18]	[18]TANG H B, LI Y S, MIYANO K, et al.Phosphorylation of TRPV1 by neurokinin-1 receptor agonist exaggerates the capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons[J].Neuropharmacology, 2008, 55 (8) :1405-1411.
[19]	[19]NORREGAARD R, JENSEN B L, TOPCU S O, et al.Cyclooxygenase type 2 is increased in obstructed rat and human ureter and contributes to pelvic pressure increase after obstruction[J].Kidney International, 2006, 70 (5) :872-881.
[20]李江, 方克伟.骨骼肌卫星细胞成肌化机制研究进展[J].医学研究生学报, 2016, 29 (9) :999-1003.
[21]	[21]BEAULIEU D, THEBAULT P, PELLETIER R, et al.Abnormal prostaglandin E2 production blocks myogenic differentiation in myotonic dystrophy[J].Neurobiology of Disease, 2012, 45 (1) :122-129.
[22]	[22]GUERCI A, LAHOUTE C, HEBRARD S, et al.Srf-Dependent Paracrine Signals Produced by Myofibers Control Satellite Cell-Mediated Skeletal Muscle Hypertrophy[J].Cell Metabolism, 2012, 15 (1) :25-37.

相关文章(20)

[1]	谢峻, 刘绍有, 施鸿金, 毛秋玉, 杨宏. EZH2抑制剂与膀胱癌GC化疗药物联用增敏的作用研究, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20231017
[2]	董丹红, 王维雯, 李德霞, 杨军, 李娜, 马航, 李琳. 慢性射血分数降低的心力衰竭患者药物治疗现状云南单中心调查分析, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230822
[3]	陈星慧, 高竹薇, 张广斌, 何军晶, 牛雅茹, 马丽莎. 射频治疗阴道前壁脱垂伴压力性尿失禁的疗效分析, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20221004
[4]	孟春梅, 袁涛, 张义凤, 马永红, 叶珂帆, 吴晓梅, 自蓉. 生物电治疗压力性尿失禁的盆底超声评估, 昆明医科大学学报.
[5]	林义临, 张宏, 丁筱雪. 脑啡肽酶抑制剂治疗慢性心衰的研究进展, 昆明医科大学学报.
[6]	张建华, 申正超, 陈印, 顾鹏, 赵晖, 申吉泓, 柯坤彬. 铥激光治疗合并尿道狭窄的非肌层浸润性膀胱肿瘤, 昆明医科大学学报.
[7]	李勤, 姜黎黎, 史惠云, 李春梅, 李俊, 胡艳丽. 云南省女性压力性尿失禁发生的产科相关危险因素, 昆明医科大学学报.
[8]	彭信刊, 张燕萍, 黄荣芳, 高然, 杨文涓. 电刺激联合生物反馈治疗非产后患者压力性尿失禁疗效观察, 昆明医科大学学报.
[9]	唐爱群. 原发性高血压患者尿白蛋白/尿肌酐比与心踝血管指数的相关性, 昆明医科大学学报.
[10]	袁华苑. 慢性心力衰竭2 106例药物治疗分析, 昆明医科大学学报.
[11]	高继学. 延安市女性压力性尿失禁流行病学调查分析, 昆明医科大学学报.
[12]	王兴宁. 尿微量白蛋白与肌酐比值在2型糖尿病早期肾损伤中的应用, 昆明医科大学学报.
[13]	曹绍党. 琥珀酸索利那新治疗经尿道前列腺电切术后患者尿失禁20例报道, 昆明医科大学学报.
[14]	谷万港. 基于结构的HIV-1蛋白酶抑制剂的虚拟筛选, 昆明医科大学学报.
[15]	谷万港. 基于结构的HIV-1蛋白酶抑制剂的虚拟筛选, 昆明医科大学学报.
[16]	郝应禄. 三维电标测指导下室性心律失常的射频消融治疗临床研究, 昆明医科大学学报.
[17]	. 丝氨酸蛋白酶抑制剂对新生血管抑制作用的研究进展, 昆明医科大学学报.
[18]	. 男性尿道断裂167例治疗分析, 昆明医科大学学报.
[19]	. 天花粉蛋白注射液结合中药治疗异位妊娠临床分析, 昆明医科大学学报.
[20]	. 不同方法治疗输卵管妊娠后生育结局的临床分析, 昆明医科大学学报.