摘要:
目的 探究可溶性细胞因子受体及基质金属蛋白酶与胰腺癌的关系.方法 选取2014年4月至2016年5月期间西双版纳州人民医院收治的59例胰腺癌患者为观察组, 并选取同时间段同龄的59名体检显示健康的人员为对照组, 检测与比较对照组和观察组的血清可溶性细胞因子受体及基质金属蛋白酶相关指标水平, 然后比较观察组中不同Hemrick分期及病理分类患者的检测结果, 以Logistic分析可溶性细胞因子受体及基质金属蛋白酶与胰腺癌的关系.结果 观察组的血清可溶性细胞因子受体及基质金属蛋白酶相关指标水平均高于对照组, 且Hemrick分期较高患者的检测水平高于Hemrick分期较低的患者, P<0.05, 但是不同病理分类患者的检测水平差异无统计学意义, P>0.05, 经Logistic分析显示, 可溶性细胞因子受体及基质金属蛋白酶均与胰腺癌有密切的关系.结论 胰腺癌患者的可溶性细胞因子受体及基质金属蛋白酶呈现高表达状态, 且对于Hemrick分期也有一定的反应价值, 因此对胰腺癌患者进行上述指标的监测价值较高.
Abstract:
Objective To investigate the relationship between soluble cytokine receptors, matrix metalloproteinases and pancreatic cancer.Methods Fifty-nine patients with pancreatic cancer in our hospital from April 2014 to May 2016 were selected in the observation group, 59 healthy subjects were selected in the control group, then the serum soluble cytokine receptors and matrix metalloproteinases levels of control group and observation group were detected and compared, and the detection results of observation group with different Hemrick stages and pathological classifications were compared, then the relationship between soluble cytokine receptors, matrix metalloproteinases and pancreatic cancer were analyzed by the Logistic analysis.Results The serum soluble cytokine receptors and matrix metalloproteinases levels of observation group were all higher than the levels of control group, the detection levels of patients with higher Hemrick stages were all higher than the levels of patients with lower Hemrick stages, all P <0.05, while the detection levels of patients with different pathological classifications had no obvious differences, all P >0.05, the Logistic analysis showed that the soluble cytokine receptors and matrix metalloproteinases all had close relationship to the pancreatic cancer.Conclusion Thesoluble cytokine receptors and matrix metalloproteinases of patients with pancreatic cancer show higher expression state, and have a indication value for the Hemrick staging, these indexes have high monitoring value for pancreatic cancer.
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