血浆FKN浓度预测冠脉病变严重程度

王宇; 苗文清; 光雪峰; 杨俊; 张义红; 田青; 段会仙; 汪艳

血浆FKN浓度预测冠脉病变严重程度

1. 昆明市第一人民医院心血管内科
2. 昆明市延安医院心血管内科

基金项目:

基金：昆明市科技局科研基金资助项目(2016-1-S-06193);

计量
- 文章访问数: 1798
- HTML全文浏览量: 627
- PDF下载量: 74
- 被引次数: 0
出版历程
- 收稿日期: 2016-11-03

Prediction of the Severity of Coronary Artery Disease by Plasma FKN Concentration

Funds:

基金：昆明市科技局科研基金资助项目(2016-1-S-06193);

摘要

摘要: 目的探讨血浆FKN浓度预测冠心病患者冠脉病变严重程度的价值.方法对2015年7月至12月于昆明市第一人民医院行冠脉介入诊断和\或治疗的患者89例,按冠脉造影结果,将患者分为3组,其中急性心肌梗死(AMI)患者或血管严重病变患者43例(B组);冠脉血管单支轻度病变患者26例(B1组);冠脉造影正常,排除冠心病患者20例(N组),共计89例.分别收集各组临床基线资料.采用ELISA法测定FKN浓度.用SPSS进行统计分析.结果研究结果,FKN浓度B组>B1组>N组,各组之间差异有统计学意义(P<0.000).FKN浓度与c Tn T及冠脉Gensini评分呈正相关,差异有统计学意义(P<0.05).研究中FKN诊断冠心病的ROC曲线下面积(AUC)0.784,诊断冠心病急性心肌梗死的界值为1.996 ng/mL.结论研究发现血浆FKN浓度随冠脉病变程度逐渐升高.血浆FKN浓度诊断的特异性及敏感性与c Tn T相似,能为冠心病患者预测冠脉病变严重程度提供依据.
- FKN /
- 冠状动脉粥样硬化性心脏病 /
- 急性心肌梗死
Abstract: Objective To investigate the value of the plasma FKN concention in prediction of the severity of coronary heart disease(CHD). Methods In this study, 89 patients who underwent coronary intervention therapy in our hospital between July and December 2015 were sequentially selected. Patients were divide into 3 groups according to the result of Coronary angiography, including group B: 43 patients of acute myocardial infarction(AMI) or Coronary Severe lesions;group B1: 26 patients of single mild Coronary lesions;group N: 20 patients with no Coronary heart disease(CHD),excluded by normal Coronary angiography result. The baseline clinical data of all 89 patients were collected. Enzyme-linked immunosorbent method was used to test the FKN level. SPSS 20.0Statistical software was used for data analysis. Results The FKN levels of patients were decreased in all 3 groups:group B> group B1>group N, with significant differencesbetween the three groups(P <0.000). There was a positive correlation between FKN and Gensini score or hs c Tn T(P<0.05). The area under the curve(AUC) of the receiver operating characteristic(ROC) curves was 0.784, the diagnostic reference value for Coronary heart disease(CHD) acute myocardial infarction was 1.996 in this sudy. Conclusions The plasma FKN levels are positively correlated to the severity of coronary lesion. The specificity and sensitivity of plasma FKN level for coronary heart disease(CHD) diagnosis is similar to CTn T. The plasma FKN levels can provide evidence of lesion severity of Coronary heart disease(CHD).
- FKN /
- Coronary heart disease /
- Acute myocardial infarction

HTML全文

参考文献(23)

[1]	[1]MORAN A,GU D,ZHAO D,et al.Future cardiovascular disease in china:Markov model and risk factor scenario projections from the coronary heart disease policy model-China[J].Circ Cardiovasc Qual Outcomes,2010,3(3):243-252.
[2]	[2]SMITH SC J R,ZHENG Z J.The impending cardiovascular pand-emic in China[J].Circ Cardiovasc Qual Outcomes,2010,3(3):226-227.
[3]	[3]CHENG S,MASSARO J M,FOX C,et al.Adiposity,cardiometabolic risk,and vitamin D status:the Framingham Heart Study[J].Diabetes,2010,59(1):242-248.
[4]中华医学会心血管病分会,中华心血管病杂志编辑委员会,中国循环杂志编辑委员会.急性心肌梗死诊断和治疗指南[J].中华心血管病杂志,2001,29(12):710-725.
[5]	[5]BAZAN J F,BACON K B,HARDIMAN G J.A new class of membrane bound chemokine with a CX3C motif[J].Nature,1997,385(9):640-644.
[6]	[6]HASKELL C A,CLEARY M D,CHARO I F.Unique role of the chemokine domain of fractalkine in cell capture.Kinetics of receptor dissociation correlate with cell adhesion[J].J Biol Chem,2000,275(10):34183-34189.
[7]	[7]IMAI T,HIESHIMA K,HASKELL C,et al.Identification and molecular characterization of fractalkine receptor CX3CR1,which mediates both leukocyte migration and adhesion[J].Cell,1997,91(4):521-530.
[8]	[8]WHITE G E,GREAVES D R.Fractalkine:a survivor’s guide:chemokines as antiapoptotic mediators[J].Arterioscler Thromb Vasc Biol,2012,32(3):589-594.
[9]	[9]WHITE G E,TAN T C,JOHN A E,et al.Fractalkine has anti-apoptotica and proliferative effects on human vascular smooth muscle cells via epidermal growth factor receptor signaling[J].Cardiovasc Res,2010,85(4):825-835.
[10]	[10]APOSTOLAKIS S,KRAMBOVITIS E,VLATA Z,et al.CX3CR1 receptor is up-regulated in monocytes of coronary artery diseased patients:impact of pre-inflammatory stimuliand renin-angiotensin system modulators[J].Thromb Res,2007,121(3):387-395.
[11]	[11]IKEJIMA H,IMANISHI T,TSUJIOKA H,et al.Upregulation of fractalkine and its receptor,CX3CR1,is associated with coronary plaque rupture in patients with unstable angina pectoris[J].Circ J,2010,74(2):337-345.
[12]安结,毕磊,郑柳颖,等.趋化因子受体Cx3CRl的基因多态性与冠状动脉粥样硬化的相关性研究[J].大连医科大学学报,2008,30(4):314-317.
[13]	[13]OTILIA POSTEA,VASINA,SANDRA CAUWENBERGHS,et al.Contribution of platelet CX3CR1 to platelet monocyte complex formation and vascular recruitment during hyperlipidemia[J].Arterioscler Thromb Vasc Biol,2012,32(1):1186-1193.
[14]	[14]IDA UNHAMMER NJERVE,SVEIN SOLHEIM,KETIL LUNDE,et al.Fractalkine levels are elevated early after PCI-treated ST-elevation myocardial infarction;no influence of autologous bone marrow derived stem cell injection[J].Cytokine,2014,69(9):131-135.
[15]齐天军,陈文强,姜翠玲,等.趋化因子促进冠状动脉粥样硬化斑块不稳定的分子机制[J].中华心血管病杂志,2011,39(9):797-801.
[16]刘君,雷明明,王妍,等.FKN在急性心肌梗死早期诊断中的作用[J].中国医科大学学报,2015,44(4):307-314.
[17]刘军锋,李旭,贾克刚,等.LOX-1和CX3CRl与冠状动脉狭窄性疾病关系及其预后价值的探讨[J].中华检验医学杂志,2014,37(1):66-70.
[18]戴青原,李明阳,杨萍,等.冠心病患者血浆纤维蛋白原、血栓前体蛋白水平与冠状动脉病变程度的相关性[J].昆明医科大学学报,2015,36(9):113-117.
[19]彭民安,刘传垠,万凤福,等.NT-pro BNP与冠状动脉病变严重程度的相关性[J].昆明医科大学学报,2013,34(8):81-83.
[20]于雪,张倩,刘君萌,等.冠心病患者经皮冠脉成形术前后血清亲环素A浓度变化[J].昆明医科大学学报,2015,36(11):31-34.
[21]孟丽红,张松.ACS合并混合型高脂血症患者调脂治疗1例报道[J].昆明医科大学学报,2014,35(3):156-157.
[22]章丽霞,王宇,张丽华,等.转化生长因子β1和细胞外信号调节激酶1/2在冠心病猝死早期心肌缺血中的表达及意义[J].川北医学院学报,2016,31(6):813-815.
[23]梁敏,李阳,张尔永.ACE、ACE2基因在急性主动脉夹层和冠心病患者中表达的差异性研究[J].川北医学院学报,2015,36(4):501-505.

相关文章(20)

[1]	朱晓栋, 刘演龙, 周旭, 戴海龙, 尹小龙. cMyBP-C在急性心肌梗死临床诊断中的价值, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230328
[2]	苗文清, 王宇, 赵晓丽, 田倪妮, 尤丽英. 冠心病急性心肌梗死患者外周血差异基因表达分析及功能, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220614
[3]	卢竞前, 杨锋, 尹利民, 李萍, 张全书, 贾永全, 陈敏, 潘娅萍. 经抽吸导管闭塞冠脉远段处理在高血栓负荷STEMI患者中的应用, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210118
[4]	苗文清, 王宇, 杨俊, 田倪妮, 段会仙, 赵晓丽. 血Preβ1-HDL对冠心病患者冠脉病变严重程度预测价值的相关性, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210521
[5]	田倪妮, 张鸿青, 田敏, 吕彩萍, 杨斌, 许峰, 李宏键, 潘兴华. 高龄女性急性心肌梗死患者临床特点及内质网应激因子HSP47、XBP-1S、GRP78的血清含量, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210417
[6]	谢振林, 冯雅建, 范志伟, 张东星. CARP、Myo、α1-微球蛋白在急性心肌梗死患者血清中的表达及意义, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20211123
[7]	张音, 杨丽霞, 陈燕, 何佳璇. 胸痛中心成立对急性心肌梗死救治效率的影响, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210644
[8]	谢姆西凯麦尔·奥布力喀斯木, 吐尔逊娜依·艾海提, 杨和银. 急性心肌梗死患者应用阿替普酶联合丁苯酞治疗的疗效及对血清MYO、Periostin水平的影响, 昆明医科大学学报.
[9]	罗林萍, 刘明艳, 吴翔, 聂磊. 急性心肌梗死心电图变化与冠脉造影结果的相关性, 昆明医科大学学报.
[10]	兰建军, 王琳, 王世海, 曾晓斌, 徐大文, 温华知. 急性心肌梗死患者创伤后成长状况及PTG的预测因素, 昆明医科大学学报.
[11]	高菊玲. RT-PA静脉溶栓治疗急性心机梗死临床分析, 昆明医科大学学报.
[12]	吴剑. 急性心肌梗死并发左室室壁瘤的外科治疗, 昆明医科大学学报.
[13]	杜娟. 骨髓单个核细胞移植治疗2型糖尿病小鼠急性心肌梗死的研究, 昆明医科大学学报.
[14]	陈亭杰. 基层医院开展急性心肌梗死急诊PCI 治疗临床分析, 昆明医科大学学报.
[15]	庞明杰. NT-proBNP对ST段抬高的急性心梗患者急诊PCI术后临床结果的预测价值, 昆明医科大学学报.
[16]	. 肌钙蛋白I、脑钠肽和C-反应蛋白水平与急性心肌梗死关系的临床研究, 昆明医科大学学报.
[17]	. 血浆脑钠肽对诊断急性心肌梗死后心衰的临床观察, 昆明医科大学学报.
[18]	. 急性心肌梗死患者血脂改变及其影响因素分析, 昆明医科大学学报.
[19]	. 急性心肌梗死患者血脂临床分析, 昆明医科大学学报.
[20]	. 急性心肌梗死患者急诊PCI治疗术前术后的观察与护理, 昆明医科大学学报.