信号通路在骨性关节炎发病中的作用

李龙滕; 李彦林; 王坤; 肖渝; 闫祥甲

信号通路在骨性关节炎发病中的作用

昆明医科大学第一附属医院运动医学科

基金项目:

基金：国家自然科学基金资助项目(81460340); 云南省创新团队基金资助项目(2014HC018); 云南省医疗卫生单位内设研究机构基金资助项目(2014NS161);

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出版历程
- 收稿日期: 2016-11-14

The Role of Singal Pathways in Osteoarthritis

Funds:

基金：国家自然科学基金资助项目(81460340); 云南省创新团队基金资助项目(2014HC018); 云南省医疗卫生单位内设研究机构基金资助项目(2014NS161);

摘要

摘要: 骨性关节炎(osteoarthritis,OA)是一种多种原因导致关节软骨退变和继发性骨质增生为主的慢性滑膜关节疾病,其发病机制复杂多样,尚不完全清楚,目前对OA采取的治疗方法较多,但效果均不明显,只能短期缓解症状、改善关节功能,不能阻止OA的病理进程,更不可能逆转关节软骨的退变.目前国内外对信号通路与骨性关节炎的研究成为一个热点,大量研究证实骨性关节炎的发生、发展与SDF-1/CXCR4、MAPK、Wnt、OPG/RANKL/RANK等信号通路均有关系,但没有任何一条信号通路能完全解释骨性关节炎的发病机制,也不能靠阻断单一信号通路而达到治疗OA的效果,故而针对治疗OA发病机制的研究和新型药物的研制成为了目前研究的热点.就目前国内外关于信号通路在骨性关节炎发展中的作用进行综述,希望对骨性关节炎的研究和治疗提供理论依据.
- 骨性关节炎 /
- 信号通路 /
- SDF-1 /
- CXCR4 /
- MAPK
Abstract: Osteoarthritis is the chronic articulatio-synovialis disease which features as cartilage degenerate and secondary osteoproliferation. Current pharmacologic therapy is largely ineffective at altering progression of the disease because the varitious mechanisms for OA remain elusive. The various therapeutic method of OA are not obvious,just relieve symptom or improve the function of joints in short.It is imposbille to stop pathological process of OA, not to mention reverse the degeneration of cartilage.It is a hot study between singal pathway and osteoarthritis,mroe and more researches confirm that the singal pathway of SDF-1/CXCR4,MAPK,Wnt,OPG/RANKL/RANK etc have close association with the generation and progress of OA.However, none of the singgal pathways can completely explan the mechanism of OA,or cure OA by block any singal pathway.So it is hotop to study mechanisms of OA and mew drugs.This rewiew focuses on singal pathway to OA in internation, hope to support theoretical foundation for study and therapy of OA
- Osteoarthritis /
- Signal pathway /
- SDF-1 /
- CXCR4 /
- MAPK

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参考文献(36)

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