应力下髁突软骨中相关因子对髁突生长发育作用的研究进展

张栩; 李松

应力下髁突软骨中相关因子对髁突生长发育作用的研究进展

张栩,
李松

昆明医科大学口腔学院

基金项目:

基金：国家自然科学基金资助项目(81660178);

计量
- 文章访问数: 2217
- HTML全文浏览量: 815
- PDF下载量: 90
- 被引次数: 0
出版历程
- 收稿日期: 2016-12-03

Research Progress in the Effects of Cytokines in Condylar Chondrocyte on Condylar Development under Mechanical Loading

Zhang Xu ,
Li Song

Funds:

基金：国家自然科学基金资助项目(81660178);

摘要

摘要: 髁突生长发育和代谢受到力学刺激的影响,以维持软骨内细胞及基质新陈代谢平衡,保障颞下颌关节正常的形态和功能.这个适应性改建过程依赖于软骨细胞对各种机械化学信号刺激的应答反应.就参与髁突软骨力学信号转导的一些重要因子研究进展作一综述.
- 髁突软骨 /
- 应力 /
- 细胞因子
Abstract: The growth and development of condyle is affected by the mechanical stress stimulation, which maintains the balance of condylar chondrocytes and extracellular matrix metabolism, as well as the structure and function of the temporomandibular joint. The adaptive remodeling relies on the mechanical signals response of the chondrocytes. This review aims to discuss about some of the main factors related to the mechanical stress signal transduction of the condylar chondrocytes.
- Condylar chondrocyte /
- Mechanical loading /
- Cytokine

HTML全文

参考文献(43)

[1]	[1]LI Q,ZHANG M,CHEN Y J,et al.Psychological stress alters microstructure of the mandibular condyle in rats[J].Physiol Behav,2013,110(2):129-139.
[2]	[2]GREDES T,MACK H,SPASSOV A,et al.Changes in condylar cartilage after anterior mandibular displacement in juvenile pigs[J].Arch Oral Biol,2012,57(6):594-598.
[3]盛海莹,陈潇,左艳萍,等.磷脂酶C-γ1tyr783在下颌功能前伸大鼠髁突软骨后部表达变化的研究[J].华西口腔医学杂志,2014,32(5):455-458.
[4]	[4]HAMBLI R.Connecting mechanics and bone cell activities in the bone remodeling process:An integrated finite element modeling[J].Front Bioeng Biotechnol,2014,8(2):6-8.
[5]	[5]AMOLS,PATIL,RAVINDRA B,et al.Role of insulin-like growth factors(IGFs),their receptors and genetic regulation in the chondrogenesis and growth of the mandibular condylar cartilage[J].J Cell Physiol,2012,227(5):1796-1804.
[6]	[6]SHIBATA S,FUKUOKA H,SATO R,et al.An in situ hybridization study of the insulin-like growth factor system in developing condylar cartilage of the fetal mouse mandible[J].Eur J Histochem,2012,56(2):e23.
[7]	[7]MENG Q,LONG X,DENG M,et al.The expressions of IGF-I,BMP-2 and TGF-131 in cartilage of condylar hyperplasia[J].J Oral Rehabil,2011,38(1):34-40.
[8]周椅,江莉婷,魏立,等.IGF-I、IGF-IR及Bcl-2、Bax在大鼠髁突软骨发育中的表达及作用[J].现代口腔医学杂志,2013,27(1):25-31.
[9]	[9]WATAHIKI J,YAMAGUCHI T,IRIE T,et al.Gene expression profiling of mouse condylar cartilage during mastication by means of laser microdissection and c DNA array article[J].J Dent Res,2004,83(3):245-249.
[10]郑菲菲,李松,徐芸.静压力对髁突软骨细胞形态和IGF—I及其受体表达影响的研究[J].昆明医学院学报,2008,29(1):162.
[11]李琥,李玉华,朱晓静,等.功能矫形后退大鼠下颌后髁突软骨改建的分子机制[J].南京医科大学学报(自然科学版),2006,26(8):702-705.
[12]	[12]OCHIAI T,SHIBUKAWA Y,NAGAYAMA M,et al.Indian hedgehog roles in post-natal TMJ development and organization[J].J Dent Res,2010,89(4):701-708.
[13]韩磊,张晓玲,唐国华.Indian Hedgehog在牵张力促进成骨细胞增殖中的作用研究[J].华西口腔医学杂志,2012,30(3):234-238.
[14]邹沙沙,陈婷婷,张玲玲,等.反转录病毒载体介导Indian hedgehog信号蛋白在C3H10T1/2细胞中的表达及成骨诱导潜能[J].中国组织工程研究,2012,16(24):4381-4386.
[15]	[15]CHAU M,FORCINITO P,ANDRADE A C,et al.Organization of the Indian hedgehog-parathyroid hormone-related protein system in the postnatal growth plate[J].J Mol Endocrinol,2011,47(1):99-107.
[16]	[16]KOBAYASHI T,CHUNG U I,SCHIPANI E,et al.PTHr P and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps[J].Development,2002,129(12):2977-2986.
[17]	[17]SHIBUKAWA Y,YOUNG B,WU C S,et al.Temporomandibular joint formation and condyle growth require Indian hedgehog signaling[J].Dev Dyn,2007,236(2):426-434.
[18]黄林剑,李辉,谢千阳,等.Ihh-PTHr P信号轴介导髁突软骨细胞对压力微环境改变的调控研究[J].口腔医学,2014,34(7):481-485.
[19]聂新盼,王文波,王保新,等.关节炎早期诊断方法的评价分析[J].医学综述,2012,18(14):2207-2210.
[20]	[20]MAJUMDAR M K,WANG E,MORRIS E A.BMP-2 and BMP-9 promotes chondrogenicdifferentiation of human multipotentialmesenchymal cells and overcomes the inhibitory effect of IL-1[J].J Cell Physiol,2001,189(3):275-284.
[21]	[21]BARNOUTI Z P,OWTAD P,SHEN G,et al.The biological mechanisms of PCNA and BMP in TMJ adaptive remodeling[J].Angle Orthod,2011,81(1):91-99.
[22]	[22]SHU B,ZHANG M,XIE R,et al.BMP2,but not BMP4,is crucial for chondrocyte proliferation and maturation during endochondral bone development[J].J Cell Sci,2011,124(Pt20):3428-3440.
[23]	[23]CHEN G,DENG C,LI YP.TGF-βand BMP signaling in osteoblast differentiation and bone formation[J].Int J Biol Sci,2012,8(2):272-288.
[24]	[24]BELLAC C L,DUFOUR A,KRISINGER M J,et al.Macrophage matrix metalloproteinase-12 dampens inflammation and neutrophil influx in arthritis[J].Cell Rep,2014,9(2):618-632.
[25]	[25]CONNELYJT,VANDERPLOEGEJ,MOUW JK,et al.Tensileloadingmodulates bone marow stromal celdiferentiation and the development of enginered fibrocartilage constructs[J].Tisue Eng Part A,2010,16(6):1913-1923.
[26]	[26]AL-KALALYAA,LEUNGFYC,WONGRWK,et al.The molecular markers for condylar growth:Experimental and clinical implications[J].Orthodontic Waves,2009,68(2):51-56.
[27]	[27]XIONG H,RABIE A B,HAGGU.Mechanical strain leads to condylar growth in adult rats[J].Front Biosci,2005,1(10):67-73.
[28]	[28]CHEN J,SORENSEN K P,GUPTA T,et al.Altered functional loading causes differential effects in the subchondral bone and condylar cartilage in the temporomandibular joint from young mice[J].Osteoarthritis Cartilage,2009,17(3):354-361.
[29]	[29]DYP,WANGW,BHATARAM P,et al.Sox9 directs hypertrophic maturation and blocks osteoblast diferentiation of growth plate chondrocytes[J].Develop Cel,2012,22(3):597-609.
[30]	[30]DING M,LU Y,ABBASSI S,et al.Targeting Runx2 expression in hypertrophic chondrocytes impairs endochondral ossification during early skeletal development[J].J Cell Physiol,2012,227(10)∶3446-3456.
[31]	[31]MANIOTIS A,CHEN C,INGBER D.Demonstration of mechanical connections between integrins,cytoskeletal filaments,and nucleoplasm that stabilize nuclear structure[J].Proceedings of the National Academy of Sciences,1997,94(3):849-854.
[32]	[32]WANG J H,THAMPATTY B P.An introductory review of cell me-chanobiology[J].Biomech Model Mechanobiol,2006,5(1):1-16.
[33]	[33]GAHMBERG C G,FAGERHOLM S C,NURMI S M,et al.Regulation of integrin activity and signaling[J].BiochimBiophys Acta,2009,1790(6):431-444.
[34]	[34]MARQUES M R,HAJJAR D,FRANCHINI K G,et al.Mandibular appliance modulates condylar growth through integrins[J].J Dent Res,2008,87(2):153-158.
[35]江莉婷,谢银银,魏立,等.大鼠髁突软骨细胞发育中差异蛋白的表达变化[J].中国口腔颌面外科杂志,2013,11(1):15-23.
[36]	[36]LANFER B,SEIB F P,FREUDENBERG U,et al.The growth and differentiation of mesenchymal stem and progenitor cells cultured on aligned collagen matrices[J].Biomaterials,2009,30(30):5950-5958.
[37]	[37]BAE J,TAKAHASHI I,SASANO Y,et al.Age-related changes in gene expression patterns of matrix metalloproteinases and their collagenous substrates in mandibular condylar cartilage in rats[J].Journal of Anatomy,2003,203(2):235-241.
[38]王艳明.前伸下颌后大鼠髁突软骨内MMPs和TIMP-1表达变化的研究[D].成都:四川大学口腔临床医学博士学位论文,2005.
[39]	[39]PATIL A,SABLE R,KOTHARI R.Genetic expression of MMP-Matrix-mettalo-proteinases(MMP-1 and MMP-13)as a function of anterior mandibular repositioning appliance on the growth of mandibular condylar cartilage with and without administration of Insulin like growth factor(IGF-1)and Transforming growth factor-B(TGF-β)[J].Angle Orthod,2012,82(6):1053-1059.
[40]	[40]KUANG B,DAI J,WANG Q Y,et al.Combined degenerative and regenerative remodeling responses of the mandibular condyle to experimentally induced disordered occlusion[J].Am J Orthod Dentofacial Orthop,2013,143(1):69-76.
[41]	[41] NELSON A R,FINGLETON B,ROTHENBERG M L,MATRISIAN L M.Matrix metalloproteinases:biologic activity and clinical implications[J].J Clin Oncol,2000,18(5):1135-1149.
[42]	[42]DUERR S,STREMME S,SOEDER S,BAU B,AIGNER T.MMP-2/gelatinase A is a gene product of human adult artivular chondrocytes and is increased in osteoarthritic cartilage[J].Clin Exp Rheumatol,2004,22(5):603-608.
[43]	[43]SODER S,ROACH H I,OEHLER S,et al.MMP-9/gelatinase B is a gene product of human adult articular chondrocytes and increased in osteoarthritic cartilage[J].Clin Exp Rheumatol,2006,24(3):302-304.

相关文章(20)

[1]	钱石兵, 史会萍, 李艳秋, 杨镕羽, 段开文. 根尖牙乳头干细胞成骨分化的研究进展, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20240926
[2]	李芬, 赵婕, 张海溪, 张琳, 辜学忠. 噬血细胞综合征患者的铁代谢指标、细胞因子和肝功能的相关性, 昆明医科大学学报.
[3]	方翠华, 潘茂华, 周隆参, 覃宇城, 黄亚铭, 马佳, 陈熙, 杨照青. 黑色素瘤免疫治疗现状及研究进展, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230519
[4]	董建芳, 尹茜晶, ）陈祖聪, 张雪飞, 周泽平. 免疫相关分子在原发免疫性血小板减少症中的研究进展, 昆明医科大学学报.
[5]	赵琨, 肖云, 杨纯, 严志凌, 董敏娜, 向柄全, 肖茗耀. 白细胞介素-4在脂多糖诱导急性肺损伤模型中的保护作用, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220805
[6]	毛瑞, 何影, 代自超, 李松. SOX9在SD大鼠胚胎发育髁突软骨与胫骨生长板软骨中的时间表达研究, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220210
[7]	刘幸, 李海雯, 黄红丽, 沈凌筠, 张乐, 刘向芳, 张文林, 王璐. 益生菌强化肠内营养支持对重症急性胰腺炎患者胃肠道功能和炎症因子的影响, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20211116
[8]	杨金荣, 武坤, 聂波, 贺振新, 杨雨宇, 孙杰, 曾云. 成人HPS临床特征及多种细胞因子水平与预后的相关性, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20211220
[9]	周玮莎, 张乐, 彭静, 陈寿坤, 刘梦君, 符晓, 唐志飞, 岳云璇. 血浆置换加双重血浆分子吸附对自身免疫性肝炎合并肝衰竭的细胞因子的影响, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210414
[10]	赵维佳, 李红宾, 陈宗翰. 窄谱中波紫外线联合卡泊三醇治疗银屑病症状转归及患者治疗前后外周血细胞因子水平评价, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20201227
[11]	吕松琴, 赵华, 宝福凯, 李晓非, 闫新丽, 张娟, 段洪芬. TNF-α和IFN-γ与T-SPOT.TB相结合应用于鉴别结核现症感染与隐性感染, 昆明医科大学学报.
[12]	刘少星. 帕瑞昔布钠预先给药对大鼠局灶脑缺血再灌注血脑屏障通透性的影响, 昆明医科大学学报.
[13]	张洋. 炎症及氧化应激反应在慢性阻塞性肺疾病发病机制中的研究进展, 昆明医科大学学报.
[14]	薛恩忠. 高血压合并糖尿病患者血清粘附因子与炎性因子水平及相关性研究, 昆明医科大学学报.
[15]	杨婧. Th17细胞及相关细胞因子在原发性胆汁性肝硬化患者的表达, 昆明医科大学学报.
[16]	杨德兴. 脓毒性休克对恒河猴血流动力学、器官损伤及细胞因子释放的影响, 昆明医科大学学报.
[17]	李玲玲. 不对称咀嚼力作用下CTGF在髁突软骨中的表达, 昆明医科大学学报.
[18]	伍尚敏. Shh在血管瘤中的表达及意义, 昆明医科大学学报.
[19]	李玉晓. 大蒜新素对变应性鼻炎患者外周血白介素4和γ干扰素的影响, 昆明医科大学学报.
[20]	周义忠. 血IL-10、IL-5、IL-2、IFN-γ水平在反复腹痛患儿及其家庭成员中的比较, 昆明医科大学学报.