Abstract: Objective To explore the CT imaging features of Castleman's disease, and improve the awareness of Castleman's disease before surgery. Methods The clinical data and CT imaging data of 13 patients with pathologically proved Castleman's disease were analyzed retrospectively. Results Nine cases were localized with hyaline vascular type in pathological classification, including 4 cases in chest(2 cases in lung, 2 cases in mediastinum), 5 cases in abdomen(1 case in abdominal cavity and 4 case in retroperitoneum). Four cases were multicentric with lesions distributed in the lung, abdominal cavity, axillary and groin, and pathologically classified into hyaline vascular type in 1, plasma cell type in 10, and mixed type in 2.All lesions were of iso-density on plain CT with well-defined margin.After intravenous administration of contrast agent, the markedly and long-lasted enhancement was seen in all localized cases with hyaline vascular type. While multicentric cases showed different enhancement with correspond with different pathological classification, which 2 cases were markedly enhancement,but 2 cases were mild-moderate enhancemeny. Two of localized lesions were found with punctate, branching calcification, and 3 of localized lesions were found with peripheral scattered enlarged lymph nodes which were pathologically confirmed as reactive lymphadenitis. Conclusions The localized Castleman's disease with predominanthyaline vascular type has characteristics on CT images, including soft tissue mass with markedly and long-lasted enhancement, and some of cases with branching calcification and satellite lesions. However,multicentric Castleman's disease has no obvious features for diagnosis.