Abstract: Objective To observe the safety and efficacy of concurrent radiotherapy and chemotherapy in the treatment of invasive carcinoma of cervix, and to evaluate its clinical value. Methods We selected 86 patients treated in our hospital in January 2013-2015 year in March according to the diagnostic criteria of invasive cervical cancer in this study, and randomly divided them into two groups, with 43 cases in each group. The simple group was given single radiotherapy before operation, including half amount of radiotherapy in the the cavity, 7Gy each time, 1time/week, total dose of 21 Gy * 3 times. The combined group was given preoperative radiotherapy and chemotherapy, including 21 Gy * 3 times of radiotherapy, and intravenous instillation of 20 mg/m2 of cisplatin for continuous 5 days form the first day of radiotherapy. Patients in both groups were given surgical treatment 2 weeks after single radiotherapy or combined radiotherapy and chemotherapy, then the curative effects of two groups were compared. Results The effective rate of combined group was 90.7%(39 cases) and was higher than that of simple group 72.1%(31 cases)(P<0.05). The parametrial invasion and lymph node positive rate in the combined group was lower than that in the simple group(P<0.05). There was no statistically significant difference in the white blood cell decrease,the incidence of nausea, vomiting, diarrhea and abnormal liver and kidney function between two groups(P>0.05). The hair loss rate in the combined group was 48.8%(21 cases),which was higher than the simple group(0 %)(P<0.05). Conclusion Concurrent chemotherapy in the treatment of cervical cancer infiltration is better, the infiltration and lymph node positive rate is lower, but the incidence of hair loss is higher,so it has important clinical value.