Abstract: Objective To quantitatively analyze the effectiveness and expense of VSD in diabetic foot ulcer and provide the reliable evidence for clinical decision and practice bu using the Evidence-Based Medicine methods.Methods We searched randomized controlled trials that advertised in magazines or journals of china that before December of 2016 in CNKI, CBM, VIP and Wan Fang Database, and selected articles that conformed to inclusion-standard and the references were also retrieved, and then evaluated the quality of the articles by the quality evaluation standard of Cochrane collaboration, meta-analysis was performed by software Revman5.3.Results Four articles were included and the general quality was moderate;meta-analysis showed that the effect and expense of VSD was superior to other interventions in the treatment of diabetic foot ulcer;but the unsymmetrical funnel plot suggested the existence of publication bias. Conclusions In the treatment of diabetic foot ulcer, the effect and expense of VSD is superior to other interventions,deserves to expand and apply in hospitals,but due to the existence of publication bias,the meta-analysis results need more reliable evidences to support in the future.