Tiam1和Fascin在食管鳞癌中的表达及临床意义

张金添; 余雪莹; 谢群

Tiam1和Fascin在食管鳞癌中的表达及临床意义

1. 莆田学院基础医学部病理教研室
2. 莆田学院临床医学院

基金项目:

基金：福建省教育厅科研基金资助项目 (JA15442); 福建省大学生创新创业计划资助项目 (201611498036);

计量
- 文章访问数: 1579
- HTML全文浏览量: 591
- PDF下载量: 56
- 被引次数: 0
出版历程
- 收稿日期: 2017-03-04

Expression of Tiam1 and Fascin in Esophagus Squamous Carcinoma and Its Clinical Significance

Funds:

基金：福建省教育厅科研基金资助项目 (JA15442); 福建省大学生创新创业计划资助项目 (201611498036);

摘要

摘要: 目的探讨Tiam1和Fascin在食管鳞癌中的表达及意义.方法采用免疫组化SP法检测Tiam1、Fascin在食管鳞癌和食管正常组织中的表达.结果 Tiam1、Fascin在食管鳞癌中的表达高于食管正常组织中的表达 (P<0.05) , Tiam1和Fascin的表达与食管鳞癌的TNM分期、浸润深度及淋巴结转移密切相关, Tiam1表达与食管鳞癌病理分级有关, 而Fascin的表达与食管鳞癌病理分级无关;Tiam1与Fascin在食管鳞癌中的表达具有相关性 (r=0.302, P<0.01) .结论 Tiam1、Fascin在食管鳞癌组织中表达上调, 同时与食管鳞癌的侵袭、转移密切相关;Tiam1和Fascin可能在食管鳞癌癌变过程中起协同作用;以Tiam1、Fascin为靶点可能为食管鳞癌的治疗提供新的思路.
- 食管鳞癌 /
- Tiam1 /
- Fascin
Abstract: Objective To investigate the clinical significance of Tiam1 and Fascin protein expression in esophagus squamous carcinoma.Me thods Immunohistochemical SP method was used to detect Tiam1, Fascin protein in esophageal squamous carcinoma and normal esophageal tissue. Re s ults Tiam1, Fascin protein expression in esophageal squamous carcinoma tissues was significantly higher in the expression of normal esophageal tissue (P<0.05) , which was correlated with TNM stage, infiltration degree, lymphatic metastasis.Tiam1 protein expression was related to pathological grading of esophageal squamous carcinoma., and Fascin protein expression has no relation with the pathological grading of esophageal squamous carcinoma.There was close correlation between Tiam1 protein and Fascin protein (r = 0.302, P <0.01) . Conclus ions The higher expression of Tiam1 and Fascin in esophageal squamous carcinoma, are closely associated with invasion and metastasis. Tiam1 and Fascin may synergy effect in the process of esophageal squamous carcinoma. Tiam1, Fascin may become new targets in the therapy of esophagus squamous carcinoma.
- Esophagus squamous carcinoma /
- Tiam1 /
- Fascin

HTML全文

参考文献(16)

[1]	[1]HABETS G G, SCHOLTES E H, ZUYDGEEST D, et al.Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins[J].Cell, 1994, 77 (4) :537-549.
[2]	[2]YANG W, LV S, LIU X, etal.Up-regulation of Tiam1 and Rac1 correlates with poor prognosis in hepatocellular carcinoma[J].Jpn J Clin Oncol, 2010, 40 (11) :1053-1059.
[3]	[3]QI Y, HUANG B, YU L, et al.Prognostic value of Tiam1and Rac1 overexpression in nasopharyngeal carcinoma[J].ORL J Otorhinolaryngol Relat Spec, 2009, 71 (3) :163-171.
[4]	[4]WANG S, LI S, TANG Q, et al.Overexpression of Tiam1promotes the progression of laryngeal squamous cell carcinoma[J].Oncol Rep, 2015, 33 (4) :1807-1814.
[5]	[5]SHI Y L, MIAO R Z, CHENG L, et al.Up-regulation of T-lymphoma and metastasis gene in gastric cancer and its involvement in cell invasion and migration[J].Chin Med J (Engl) , 2013, 126 (4) :640-645.
[6]	[6]WANG H M, WANG J.Expression of Tiam1 in lung cancer and its clinical significance[J].Asian Pac J Cancer Prev, 2012, 13 (2) :613-615.
[7]	[7]SUBRAMANIAN N, NAVANEETHAKRISHNAN S, BISWAS J, et al.RNAi mediated Tiam1 gene knockdown inhibits invasion of retinoblastoma[J].PLo S One.2013, 8 (8) :e70422.
[8]	[8]BOURGUIGNON L Y, ZHU H, SHAO L, CHEN YW, et al.Ankyrin-Tiam1?interaction promotes Rac1 signaling and metastatic breast tumor cell invasion and migration[J].J Cell Biol, 2000, 150 (1) :177-191.
[9]	[9]MALLIRI A, VAN DER KAMMEN R A, CLARK K, et al.Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours[J].Nature, 2002, 417 (6891) :867-871.
[10]朱金明, 余佩武, 赵永亮, 等.Tiam1反义寡核苷酸转染对胃癌细胞体内外侵袭转移能力的影响[J].中国癌症杂志, 2007, 17 (10) :788-791.
[11]	[11]CHOI P J, YANG D K, SON C H, et al.Fascin immunoreactivity for preoperatively predicting lymph node metastases in peripheral adenocarcinoma of the lung 3 cm or less in diameter[J].Eur J Cardiothorac Surg, 2006, 30 (3) :538-542.
[12]	[12]YANG S, HUANG F K, HUANG J, et al.Molecular mechanism of fascin function in filopodial formation[J].J Biol Chem, 2013, 288 (1) :274-284.
[13]	[13]HWANG J H, SMITH C A, SALHIA B, et al.The role of fascin in the migration and invasiveness of malignant glioma cells[J].Neoplasia, 2008, 10 (2) :149-159.
[14]	[14]DARNEL A D, BEHMOARAM E, VOLLMER R T, et al.Fascin regulates prostate cancer cell invasion and is associated with metastasis and biochemical failure in prostate cancer[J].Clin Cancer Res, 2009, 5 (4) :1376-1383.
[15]	[15]HUANG X, JI J, XUE H, et al.Fascin and cortactin expression is correlated with a poor prognosis in hepatocellular carcinoma[J].Eur J Gastroenterol Hepatol, 2012, 24 (6) :633-639.
[16]	[16]OH S Y, KIM Y B, SUH K W, et al.Prognostic impact of fascin-1 expression is more significant in advanced colorectal cancer[J].J Surg Res, 2012, 172 (1) :102-108.

相关文章(20)

[1]	庄利萍, 王开昕, 王芳, 叶宏. COX2和CDX2在喉鳞癌中的表达特点及其与喉鳞癌患者预后的关系, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230529
[2]	宋飞, 向盈盈, 张纪贵, 车佳音, 李林, 黄明. 经桡动脉途径与股动脉途径介入治疗肺鳞癌的对比, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210921
[3]	冯恩梓, 王登欢, 张冉, 杨兴宇, 张楠, 杨洁, 吴锡芳. HPV在口咽鳞癌的临床意义, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20211109
[4]	陈思宇, 付帅, 吴勇. 醋酸棉酚对人舌鳞癌Cal-27细胞侵袭性作用的实验研究, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20201101
[5]	姜慧, 张娟, 徐丹, 何黎. 紫外线诱导SKH-1无毛小鼠皮肤鳞癌模型的构建及DNA-PKcs在小鼠及成人皮肤组织的表达, 昆明医科大学学报.
[6]	田瑞, 段振玲, 马敬. LRG1在宫颈鳞癌组织中的表达及其与微血管密度的关系, 昆明医科大学学报.
[7]	张雪芹, 徐晓林. 兰索拉唑在胃食管反流患者中的临床效果及对食管动力学的影响, 昆明医科大学学报.
[8]	王家祝, 刁先民, 康真, 常润生, 雷子发, 孙黎, 王兆敏, 曹娥, 李文辉. 云南个旧锡矿工人职业相关肺癌病理变化及97例鳞癌治疗与生存, 昆明医科大学学报.
[9]	尚艺泰, 杨洁, 李磊, 李晓江. 重组人血管内皮抑制素联合放化疗治疗局部晚期头颈部鳞癌, 昆明医科大学学报.
[10]	李蓝江, 许冰莹, 杨春艳, 赵川, 田心. 基质金属蛋白酶1在云南汉族口腔鳞癌发病风险中的相关性, 昆明医科大学学报.
[11]	杨友同, 茹玉航, 王坤, 郝樊. 食管癌分别行管状胃代食管吻合术与传统全胃代食管吻合术对术后胃食管反流病情的控制效果, 昆明医科大学学报.
[12]	王艳萍. 利用无创性观测指标推断食管静脉曲张程度的探索, 昆明医科大学学报.
[13]	龙翔宇. 替吉奥联合放疗治疗老年局部晚期食管癌疗效观察, 昆明医科大学学报.
[14]	吴京蔓. 舌鳞癌Cal27裸鼠移植瘤模型的建立及其意义, 昆明医科大学学报.
[15]	朱嘉卫. 非洲儿童食管硬币异物诊治体会, 昆明医科大学学报.
[16]	陈文飞. 醋酸棉酚对人舌鳞癌Tca8113细胞hMLH1蛋白及mRNA表达的影响, 昆明医科大学学报.
[17]	周映伽. 中药加味桔梗汤防治放射性食管炎80例临床观察, 昆明医科大学学报.
[18]	王红明. 抗人肺鳞癌单克隆抗体的制备和纯化, 昆明医科大学学报.
[19]	鲁朝学. 56例老年胃食管反流病患者临床特征分析, 昆明医科大学学报.
[20]	. 泮托拉唑联合莫沙必利治疗胃食管吻合术后反流性食管炎92例分析, 昆明医科大学学报.