Tiam1和Fascin在食管鳞癌中的表达及临床意义

张金添; 余雪莹; 谢群

Tiam1和Fascin在食管鳞癌中的表达及临床意义

1. 莆田学院基础医学部病理教研室
2. 莆田学院临床医学院

基金项目:

基金：福建省教育厅科研基金资助项目 (JA15442); 福建省大学生创新创业计划资助项目 (201611498036);

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出版历程
- 收稿日期: 2017-03-04

Expression of Tiam1 and Fascin in Esophagus Squamous Carcinoma and Its Clinical Significance

Funds:

基金：福建省教育厅科研基金资助项目 (JA15442); 福建省大学生创新创业计划资助项目 (201611498036);

摘要

摘要: 目的探讨Tiam1和Fascin在食管鳞癌中的表达及意义.方法采用免疫组化SP法检测Tiam1、Fascin在食管鳞癌和食管正常组织中的表达.结果 Tiam1、Fascin在食管鳞癌中的表达高于食管正常组织中的表达 (P<0.05) , Tiam1和Fascin的表达与食管鳞癌的TNM分期、浸润深度及淋巴结转移密切相关, Tiam1表达与食管鳞癌病理分级有关, 而Fascin的表达与食管鳞癌病理分级无关;Tiam1与Fascin在食管鳞癌中的表达具有相关性 (r=0.302, P<0.01) .结论 Tiam1、Fascin在食管鳞癌组织中表达上调, 同时与食管鳞癌的侵袭、转移密切相关;Tiam1和Fascin可能在食管鳞癌癌变过程中起协同作用;以Tiam1、Fascin为靶点可能为食管鳞癌的治疗提供新的思路.
- 食管鳞癌 /
- Tiam1 /
- Fascin
Abstract: Objective To investigate the clinical significance of Tiam1 and Fascin protein expression in esophagus squamous carcinoma.Me thods Immunohistochemical SP method was used to detect Tiam1, Fascin protein in esophageal squamous carcinoma and normal esophageal tissue. Re s ults Tiam1, Fascin protein expression in esophageal squamous carcinoma tissues was significantly higher in the expression of normal esophageal tissue (P<0.05) , which was correlated with TNM stage, infiltration degree, lymphatic metastasis.Tiam1 protein expression was related to pathological grading of esophageal squamous carcinoma., and Fascin protein expression has no relation with the pathological grading of esophageal squamous carcinoma.There was close correlation between Tiam1 protein and Fascin protein (r = 0.302, P <0.01) . Conclus ions The higher expression of Tiam1 and Fascin in esophageal squamous carcinoma, are closely associated with invasion and metastasis. Tiam1 and Fascin may synergy effect in the process of esophageal squamous carcinoma. Tiam1, Fascin may become new targets in the therapy of esophagus squamous carcinoma.
- Esophagus squamous carcinoma /
- Tiam1 /
- Fascin

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参考文献(16)

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