Abstract: Objective To investigate the diagnostic value and correlation of corresponding laboratory indexes in rheumatoid arthritis (RA) complicated with coronary heart disease (CHD) . Me thods According to gender and age, patients were divided into RA concurrent CHD group, simple RA group, simple CHD group and healthy control group, with 102 cases in each group. The Level change of RA specificity index (ESR, RF, ACCP, IL-6) and CHD specificity index (CK, CK-MB, α-HBDH, hs-Tn T, Mb) in the four groups were analyzed retrospectively, and we statistically analyzed the correlation between the two groups of specific indicators in RA complicated with CHD group. Re s ults The rate of joint deformity in RA sick group (including simple and concurrent) was significantly higher than that in non-RA group (P =0.000) , the hypertension prevalence and smoking rate in simple CHD group were significantly higher than the other three groups (P=0.016, 0.021) , there was no significant difference in BMI and TC between the four groups (P>0.05) In patients with RA complicated with CHD, the RA specificity index of ESR, RF, ACCP and IL-6, and CKD specificity index of CK, CK-MB, hs-Tn T and Mb were significantly increased (P <0.05) . ACCP was positively correlated with CK and CK-MB (P <0.05) , IL-6 was positively correlated with CK, CK-MB and Mb (P <0.05) . Conclus ion The detection of ACCP or IL-6 in RA patients can predict the incidence of RA complicated with CHD.