吸烟与炎性因子在慢性阻塞性肺疾病急性加重期合并肺动脉高压中的相关性

李亚萍; 李永霞; 牛小群; 海冰; 曹宇; 柴燕玲

吸烟与炎性因子在慢性阻塞性肺疾病急性加重期合并肺动脉高压中的相关性

昆明医科大学第二附属医院呼吸内科二病区

基金项目:

基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2015FB052);

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出版历程
- 收稿日期: 2017-04-21

Correlation between Smoking and Inflammatory Factors in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Hypertension

Funds:

基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2015FB052);

摘要

摘要: 目的探究吸烟、炎性因子在慢性阻塞性肺疾病急性加重期 (AECOPD) 患者合并肺动脉高压 (PH) 之间的关系.方法采用回顾性分析, 收集我院2015年3月至2016年3月呼吸内科二病区住院符合诊断标准的AECOPD合并肺动脉高压患者38例为实验组, 同期住院单纯AECOPD患者46例为对照组, 收集患者基本资料, 采集患者入院后24 h内的血清中白介素-6 (IL-6) 、降钙素原 (PCT) 、超敏C反应蛋白 (hs-CRP) 、N端脑钠肽前体 (NT-proBNP) , 胸部CT和超声心动图的结果, 比较对照组和实验组两组中上述指标.结果 AECOPD合并PH组的吸烟指数、hs-CRP、PCT、NT-proBNP均高于单纯AECOPD组 (P<0.05) , 且与肺动脉收缩压呈正相关 (P<0.05) , Logistic回归分析示NT-proBNP是肺动脉高压形成的独立危险因素 (OR=1.89, P<0.01) .结论吸烟和血清中的hs-CRP、PCT、NT-proBNP升高与肺动脉压力升高呈正相关, NT-proBNP是肺动脉压升高的危险因素, 吸烟和系统炎症反应参与了COPD肺动脉高压的形成.
- 慢性阻塞性肺疾病急性加重期 /
- 肺动脉高压 /
- 吸烟 /
- 炎性因子
Abstract: Objective To explore the relationship between acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and pulmonary hypertension (PH) in patients with chronic obstructive pulmonary disease (COPD) . Me thods Using retrospective analysis, we collected from March 2015 to March 2016 in the department of respiratory internal medicine (ward two) in our hospital, 38 cases of AECOPD combined with pulmonary hypertension patients as a experimental group, 46 cases of simple AECOPD patients in the same period as the controlgroup. And we collected basic data. The serum of Interleukin-6 (IL-6) , Procalcitonin (PCT) , High sensitive C reactive protein (hs-CRP) , N-Terminal pro-Brain natriuretic peptide (NT-proBNP) were collected after admission within 24 hours, the results of Chest CT and Ultrasonic echocardiography. Compared with the control group and experimental group of two groups in the above indicators. Re s ults AECOPD combined with PH group of the smoking index, hs-CRP, PCT, NT-proBNP were higher than the simple AECOPD group (P <0.05) , and had positive correlation with pulmonary artery systolic pressure (P<0.05) . Logistic regression analysis showed that NT-proBNP was an independent risk factor for pulmonary arterial hypertension (OR=1.89, P<0.01) .Clolus ions Smoking and serum hs-CRP, PCT, NT-proB NP are positively correlated with elevated pulmonary artery pressure, NT-proB NP is an independent risk factor for pulmonary arterial hypertension. Smoking and systemic inflammation are involved in the formation of pulmonary hypertension in COPD.
- Acute exacerbation of chronic obstructive pulmonary disease /
- Pulmonary arterial hypertension /
- Smoking /
- Pulmonary arterial hypertension

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