口服恒古骨伤愈药对骨质疏松性骨折树部分血液生化指标的影响
Effect of Osteoking on Blood Biochemical Indicator of Tree Shrew with Osteoporotic Fracture
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摘要: 目的 研究恒古骨伤愈合剂口服对骨质疏松性骨折树血液生化指标的影响.方法 将30只雌性滇西亚种树随机分为对照组、模型组和治疗组, 每组10只.对照组仅切除与子宫和卵巢等体积的大网膜;模型组和治疗组切除双侧卵巢和子宫, 经6个月证实有骨质疏松后, 进行右后肢胫骨骨折术, 建立骨质疏松骨折模型.于骨折次日起, 治疗组用恒古骨伤愈合剂灌胃, 每2 d 1次;模型组和对照组用等量生理盐水灌胃.3个月后检测树血液生化指标.结果 与对照组比较, 模型组血清肌酸激酶同工酶、丙氨酸氨基转移酶、Mg2+水平显著升高 (P<0.01) ;而模型组血清总胆固醇、血糖显著降低 (P<0.01) .相对于模型组, 治疗组血清肌酸激酶同工酶、丙氨酸氨基转移酶均显著降低 (P<0.01) , Mg2+水平降低显著 (P<0.05) ;而治疗组血清总胆固醇、血糖水平明显升高 (P<0.05) .结论 恒古骨伤愈合剂对骨质疏松骨折树心脏功能和肝功能具有一定的保护作用.Abstract: Objective To observe the effect of Osteoking on blood biochemicalindicator of tree shrews with osteoporotic fracture (OPF) .Methods Totally 30 female tree shrews (Tupaiabelangeri) were randomly divided into the treatment group, the model group, and the control group, with 10 in each group. Bilateral ovaries and uterus were ectomized for 6 months in the treatment group and the model group, and right fibula fractures were induced after confirmed osteoporosis. Tree shrews in the treatment group were administered with Osteoking by gastrogavage, once per two days. Equal volume of normal saline was given to tree shrews in the model group and control group. Blood biochemical indexes were detected at 3 months after fracture.Results Compared with those in the control group, serum creatine kinase isoenzyme (CK-MB) , alanine aminotransferase (ALT) , magnesium (Mg2+) levels significantly increased (P<0.01) while total cholesterol (CHOL) and blood glucose (Glu) levels were significantly decreased (P<0.01) in the OPF model group. Compared with those in the model group, serum CK-MB and ALT significantly decreased (P<0.01) and Mg2+ significantly decreased (P<0.05) while CHOL and Glu significantly increased (P<0.05) in the treatment group. Conclusion Osteoking can protect the heart and liver function of tree shrew with osteoporotic fracture.
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Key words:
- Blood biochemical indicator /
- Osteoking /
- Tree shrews /
- Osteoporotic fracture
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