microRNAs在肺癌中的相关研究及进展

李婷; 边莉

microRNAs在肺癌中的相关研究及进展

李婷,
边莉

昆明医科大学第一附属医院病理科

基金项目:

基金：国家自然科学基金资助项目 (81460355, 2014FB020);

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出版历程
- 收稿日期: 2017-04-13

Related Research and Development MicroRNAs in Lung Cancer

Li Ting ,
Bian Li

Funds:

基金：国家自然科学基金资助项目 (81460355, 2014FB020);

摘要

摘要: microRNAs (miRNAs) 是一类长约1825个核苷酸的非编码小分子RNA, 主要通过转录后机制调控靶基因的翻译或表达, 对内源性RNA起干扰作用, 在细胞增殖、凋亡及肿瘤发生发展等多种生理和病理过程中发挥重要作用.近年来, 众多研究显示miRNAs不仅可作为肺癌早期诊断的生物标志物, 也可作为靶向治疗的有效靶点.
- miRNAs /
- 肿瘤 /
- 肺癌
Abstract: MicroRNAs (miRNAs) is a class of small molecule non-protein-coding RNA, approximately 18 to 25 nt long. MiRNAs can act as endogenous RNA interference by regulating gene expression and translation at the posttranscriptional level. MiRNAs plays an important role in cell proliferation, apoptosis and tumorigenesis and development of a variety of physiological and pathological processes. In recent years, many studies have shown that miRNAs not only can be used as biomarkers for early diagnosis of lung cancer but also be involved in effective target for targeted therapy.
- miRNAs /
- Tumor /
- Lung cancer

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参考文献(41)

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