宫颈柱状上皮异位与宫颈癌及CIN的关系
Relationship of Cervical Columnar Eithelium Ectopy with Cervical Cancer and Cervical Intraepithelial Neoplasia
-
摘要: 目的 探讨宫颈柱状上皮异位与宫颈癌及宫颈上皮内瘤变 (CIN) 的关系.方法 选取就诊于昆明医科大学院第二附属医院妇科的患者1 200例, 分为无柱状上皮异位组 (A组) 、轻度柱状上皮异位组 (B组) 、中度柱状上皮异位组 (C组) 和重度柱状上皮异位组 (D组) 4组, 均行LCT检查和HC2检测.对任一项阳性者阴道镜下取活检后送病检.分别比较各组之间LCT、HC2结果、CIN及宫颈癌疾病构成比差异有无统计学意义, 并分析年龄与宫颈柱状上皮异位的关系.结果 从年龄分组来看, 各年龄组间宫颈有无糜烂均差异有统计学意义 (P<0.01) , 且各年龄组间的宫颈柱状上皮异位程度也均差异有统计学意义 (P<0.01) ;各组LCT、HC2结果比较差异无统计学意义 (P>0.05) ;各组CIN和宫颈癌的患病情况差异无统计学意义 (P>0.05) .结论 “宫颈糜烂”与宫颈病变无必然的联系.不应该把宫颈柱状上皮异位作为宫颈病变的高危因素.Abstract: Objective To explore the relationship of cervical columnar epithelium ectopy with cervical cancer and cervical intraepithelial neoplasia (CIN) . Methods A total of 1200 cases were selected from the department of gynecology in the Second Affiliated Hospital of Kunming Medical University and were divided into four groups: no“ erosion” group (group A) , mild“ erosion” group (group B) , moderate erosion“ group (group C) and severe” erosion "group (group D) . Liquid-based cytology test (LCT) and the Hybrid Capture II (HC-2) detection were applied on all the patients. Every positive colposcopic biopsy underwent pathologic examination. LCT and HC2 results and constituent ratios of CIN and cervical cancer were compared. The relationship between age and ectopic cervical columnar epithelium were analyzed.Results There was significant difference when the presence and absence of cervical erosion and the degree of cervical columnar epithelium ectopy among all age groups were compared (P<0.01) . There was no significant difference when the LCT the HC2 results and the prevalence of CIN and cervical cancer were compared among all age groups (P >0.05) . Conclusions There is no positive connection between cervical erosion and cervical lesions. Cervical columnar epithelium ectopy should not be regarded as a risk factor of cervical lesion.
-
[1]乐杰.妇产科学[M].第7版.北京:人民卫生出版社, 2008:261-262. [2] [2]CASTLE P E.Beyond human papillomavirus;the cervix, exogenous secondary factors, and the development of cervical-precancer and cancer[J].J Lower Genital Tract D-is, 2004, 8 (3) :224-230. [3]宋学红.宫颈糜烂一个错误的诊断术语[N].健康报医学论坛, 2010-8-17 (008) . [4]刘英.宫颈糜烂程度与宫颈病变的关系初探[J].西部医学, 2010, 11 (22) :2024-2025. [5]贺国丽.关于“宫颈糜烂”的认识进展[J].现代妇产科进展, 2011, 20 (5) :407-408. [6]李雪梅, 对宫颈糜烂术语正确认识的探讨[J].包头医学院学报, 2010, 26 (4) :141-142. [7]张金芝, 李淑敏, 赵琳, 等.绝经后妇女宫颈糜烂样表现防癌筛查的临床意义[J].天津医药, 2012, 40 (10) :1068-1070. [8]回允中.女性生殖道病理学[M].北京:北京大学医学出版社, 2005:232-233. [9] [9]AN H J, CHO N H, LEE S Y, et al.Correlation of cervieal carcinoma and Precancerous lesions with human Pa Pilloma virus (HPV) genoty Pes detected With the HPV DNA chip microarray mithod[J].Cancer, 2003, 97 (3) :1672-1680. [10]王鲁平, 人乳头状瘤病毒感染与子宫颈病变关系的研究进展及应对策略[J].诊断病理学杂志, 2007, 14 (2) :86-89. [11] [11]MACHADO JUNIOR LC, DALM ASO A S, C ARVA LHO H B.Evidence for benefits from treating cervical ectopy;literature review[J].Sao Paulo Med J, 2008, 126 (2) :132-139. [12] [12]ROCHA-ZAVA LETA L, YESCAS G, CRUZ R M, et al.Human papilloma virus infection and cervical ectopy[J].Int J Gyneco l Obstet, 2004, 85 (3) :259-266. [13] [13]LUSKW J, KONECNY P.Cervicitis;a review.Cervicitis;a review[J].Current Opinion in Infectious Diseases, 2008, 21 (1) :49-55. [14]刘英.宫颈不典型鳞状细胞与宫颈病变的关系研究[J].西部医学, 2009, 21 (1) :30-31. 期刊类型引用(5)
1. 祝妮娜，董雪妮. 高频电波刀宫颈电环切除术治疗中重度宫颈柱状上皮异位的效果. 临床医学研究与实践. 2023(11): 58-61 . 
百度学术2. 陈钰茵，严坤，张飞. 重组牛碱性成纤维细胞生长因子凝胶促进宫颈柱状上皮异位面修复的临床效果. 中国医药科学. 2021(19): 102-105 . 百度学术3. 黄琼. LEEP术后病理检查与阴道镜宫颈活检对宫颈癌前病变的诊断准确性及宫颈癌漏诊相关因素分析. 中国妇幼保健. 2020(05): 960-963 . 百度学术4. 刘淼，张晓晓，李瑞珍，叶静，乌兰娜. HPV18在不同病理类型宫颈癌中miRNA表达差异研究. 河北医科大学学报. 2020(11): 1286-1290 . 百度学术5. 谢明珠，邓继红，刘双玥，张雯. 宫颈柱状上皮异位对细菌性阴道病的影响. 江苏医药. 2019(11): 1121-1124 . 百度学术其他类型引用(2)
-
点击查看大图
计量
- 文章访问数: 1764
- HTML全文浏览量: 605
- PDF下载量: 83
- 被引次数: 7
下载:
