脑神经胶质瘤患者脑脊液TSGF及HGF水平对细胞外基质重构的影响

李峰

脑神经胶质瘤患者脑脊液TSGF及HGF水平对细胞外基质重构的影响

李峰

铜川矿务局中心医院神经外科

基金项目:

基金：陕西省科技攻关基金资助项目 (2016SF-110);

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出版历程
- 收稿日期: 2017-04-19

Effects of TSGF and HGF in CSF on ECM Remodeling in Glioma Patients

Li Feng

Funds:

基金：陕西省科技攻关基金资助项目 (2016SF-110);

摘要

摘要: 目的探讨TSGF及HGF对脑神经胶质瘤进展的影响及与细胞外基质重构相关因子的关系.方法选择到铜川矿务局中心医院神经外科就诊的84例胶质细胞瘤患者, WHOⅠ级28例, Ⅱ级患者25例, Ⅲ级患者20例, Ⅳ级患者10例, 对各级患者脑脊液TSGF及HGF、MMP-2、TIMP-2、MMP-2/TIMP-2进行检测.结果Ⅱ级患者脑脊液TSGF及EGF较Ⅰ, Ⅲ级患者TSGF及EGF较Ⅰ级、Ⅱ级, Ⅳ级患者TSGF及EGF较Ⅰ级、Ⅱ级、Ⅲ级均出现显著升高, 差异有统计学意义 (P<0.05) .Ⅱ级患者MMP-2、TIMP-2及其比值较Ⅰ级差异有统计学意义 (P<0.05) , Ⅲ级患者MMP-2、TIMP-2及其比值较Ⅰ级、Ⅱ级差异有统计学意义 (P<0.05) , Ⅳ级患者MMP-2、MMP-2/TIMP-2较Ⅰ级、Ⅱ级、Ⅲ级差异有统计学意义 (P<0.05) , TIMP-2较Ⅰ级、Ⅱ级差异有统计学意义 (P<0.05) .TSGF与MMP-2、MMP-2/TIMP-2呈正相关, 与TIMP-2负相关 (P<0.05) , EGF与MMP-2、MMP-2/TIMP-2呈正相关, 与TIMP-2负相关 (P<0.05) .结论神经胶质瘤患者脑脊液内TSGF及HGF水平升高与神经胶质瘤分级密切相关, 细胞外基质重构相关因子可能参与该过程, 密切监测上述因子有助于协助判断神经胶质瘤进展.
- 神经胶质瘤 /
- TSGF /
- HGF /
- 重构
Abstract: Objective To investigate the effects of TSGF and HGF in CSF on ECM remodeling in glioma patients. Methods 83 cases of neurosurgery glioblastoma patients including grade Ⅰ 28 cases, 25 cases of patients with grade Ⅱ, Ⅲ grade 20 cases, Ⅳ grade 10 patients were enrolled. TSGF and EGF, MMP-2, TIMP-2, MMP-2/TIMP-2 were detected. Results TSGF and EGF in patients with grade Ⅱ compared with Ⅰappeared significantly higher level (P<0.05) , TSGF and EGF of Ⅲ grade patients compared with grade Ⅰ, Ⅱ grade were significantly higher (P<0.05) , TSGF and EGF of Ⅳ grade compared with gradeⅠ, Ⅱgrade, grade Ⅲ were significantly (P <0.05) . MMP-2, TIMP-2, MMP-2/TIMP-2 in grade Ⅱ patients was significantly different than that in grade Ⅰ (P <0.05) , MMP-2, TIMP-2, MMP-2/TIMP-2 in stage Ⅲpatients compared with Ⅰ, Ⅱ significantly different (P <0.05) , MMP-2, MMP-2/TIMP-2 in stage Ⅳcompared with grade Ⅰ, Ⅱ grade, grade Ⅲ showed significant difference (P <0.05) , TIMP-2 compared with grade Ⅰ, Ⅱ grade showed significant difference (P <0.05) . TSGF with MMP-2, MMP-2/TIMP-2showed significant positive correlation while showed negative correlation with TIMP-2 (P <0.05) , EGF and MMP-2, MMP-2/TIMP-2 showed significant positive correlation while showed negative correlation with TIMP-2 (P<0.05) . Conclusion Elevated cerebrospinal fluid levels of HGF and TSGF are an important factors leading to gliomas progress, the process of ECM remodeling-related factors are closely related to the progress, close monitoring those factors could help to make clear tumor progress.
- Glioma /
- TSGF /
- HGF /
- Remodeling

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