Abstract: Objective To further understand the genetic characteristics and the outcome of Familial essential tremor.Methods Clinical summary and statistical analysis were performed on the onset age, course of disease of ET, whether it is related to tremor amplitude, drug sensitivity and complication of 39 patients in 7families. Results The correlation coefficient between tremor amplitude and age at onset was rs =0.542, Correlation coefficient of tremor amplitude and duration rs =0.168; The effective rates of oral propranolol in young middle-aged group and elderly group were 79.2% and 35.7%, P=0.014; The effective rates of drinking test were 66.7% and 28.6%, P = 0.042, respectively, in young middle-aged group and elderly group;The incidence of complications in young middle-aged group and elderly group was 8.3% and 42.9%, respectivdy P =0.042.Conclusions With the growth of onset age, hearing loss and cognitive decline and other complications increase significantly; With the duration of the disease, tremor increases amplitude, drug sensitivity gradually decreases.It suggests that ET is easy to transform to other degenerative diseases, also easy to merge other degenerative diseases, This change has a certain relevance with age and heredity. Is is rather than a simple benign disease.