乌司他丁对急性胰腺炎患者氧自由基清除能力及炎性应激的改善作用
Improvement Effect of Ulinastatin for the Oxygen Free Radical Scavenging Activity and Inflammatory Stress of Patients with Acute Pancreatitis
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摘要: 目的 观察乌司他丁对急性胰腺炎患者氧自由基清除能力及炎性应激的改善作用.方法 选取2015年12月至2016年10月期间曲靖市第一人民医院收治的52例急性胰腺炎患者为观察对象, 将52例患者按照随机分配的原则分为对照组26例和观察组26例, 对照组进行常规急性胰腺炎治疗, 观察组则在对照组的基础上加用乌司他丁.将2组治疗前和治疗后不同时间的氧自由基清除能力及炎性应激指标进行比较.结果 治疗前对照组和观察组的氧自由基清除能力及炎性应激指标均差异无统计学意义 (P>0.05) , 而治疗后不同时间观察组的氧自由基清除能力及炎性应激指标均好于对照组同时间的检测结果, 差异有统计学意义 (P<0.05) .结论 乌司他丁对急性胰腺炎患者氧自由基清除能力及炎性应激的改善作用较好, 因此认为乌司他丁对此类患者的机体状态具有积极的保护作用.Abstract: Objective To study the improvement effect of ulinastatin for the oxygen free radical scavenging activity and inflammatory stress of patients with acute pancreatitis.Methods 52 patients with acute pancreatitis in our hospital from December 2015 to October 2016 were set as the observation object, and 52 patients were randomly divided into control group (26 cases) and observation group (26 cases) by the principle of random allocation. Patients in the control group were treated with routine treatment of acute pancreatitis, patients in the observation group were treated with ulinastatin on the basic treatment of control group.The oxygen free radical scavenging activity and inflammatory stress indexes of two groups before the treatment and at different time after the treatment were compared. Results The oxygen free radical scavenging activity and inflammatory stress indexes of control group and observation group before the treatment had no significant differences, all P >0.05, while the oxygen free radical scavenging activity and inflammatory stress indexes of observation group at different time after the treatment were all significantly better than the detection results of control group at the same time, all P<0.05, there were all significant differences. Conclusion The improvement effect of ulinastatin for the oxygen free radical scavenging activity and inflammatory stress of patients with acute pancreatitis is better, so the ulinastatin has active protection role for the body state of these patients.
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