不同剂量盐酸氨溴索注射液治疗老年慢性阻塞性肺疾病急性加重期患者对炎性细胞因子的影响

刘虎军; 高莉萍

不同剂量盐酸氨溴索注射液治疗老年慢性阻塞性肺疾病急性加重期患者对炎性细胞因子的影响

延安大学附属医院

基金项目:

基金：陕西省社会发展科技攻关项目 (2016SF-151);

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出版历程
- 收稿日期: 2017-04-23

Influences of Different Doses of Ambroxol Hydrochloride Injection on Inflammatory Cytokines in Treatment of Elderly Patients with Chronic Obstructive Pulmonary Disease with Acute Exacerbation

Liu Hu Jun ,
Gao Li Ping

Funds:

基金：陕西省社会发展科技攻关项目 (2016SF-151);

摘要

摘要: 目的探讨采用不同剂量盐酸氨溴索注射液治疗老年慢性阻塞性肺疾病急性加重期患者对炎性细胞因子的影响.方法选取陕西延安大学附属医院2015年5月到2016年5月收治的62例慢性阻塞性肺疾病急性加重期患者, 将患者随机分为A组和B组, 每组各31例患者.为A组患者采用盐酸氨溴索注射液治疗, 每次330 mg, B组每日盐酸氨溴索注射液90 mg治疗, 对比2组患者第1天、第4天以及第7天痰液中IL-6、IL-8以及TNF-α指标.结果 2组患者入院治疗后第1天, 痰液中IL-6、IL-8以及TNF-α指标之间的差异相对较小, 不存在统计学意义 (P>0.05) .患者入院治疗第4天、第7天, A组患者各项指标下降速度均显著优于B组患者, 差异对比均存在统计学意义 (P<0.05) ;2组不良反应发生率差异没有统计学意义 (P>0.05) .结论短时间内应用大剂量盐酸氨溴索注射液, 能够快速降低老年慢性阻塞性肺疾病急性加重期患者的临床症状, 降低患者痰液中的IL-6、IL-8以及TNF-α指标, 具有较好的抗炎价值, 建议广泛应用.
- 盐酸氨溴索注射液 /
- 老年慢性阻塞性肺疾病 /
- 炎性细胞因子
Abstract: Objective To study the influences of different doses of Ambroxol Hydrochloride Injection on the inflammatory cotokines in the treatment of elderly patients with chronic obstructive pulmonary disease patients with acute exacerbation.Methods 62 cases of elderly patients with chronic obstructive pulmonary disease with acute exacerbation in our hospital from May 2015 to May 2016 were selected and randomly divided into Group A and B, 31 cases in each group.The Group A was given Ambroxol Hydrochloride Injection treatment, 330 mg per time, and Group B was given 90 mg Ambroxol Hydrochloride Injection treatment.The IL-6, IL-8, and TNF-α Index on the1 st day, 4 th day and 7 th day after the treatment in these two groups were compared.Results On the 1 st day, the sputum IL-6, IL-8 and TNF-αafter treatment had no statistically significant difference between two groups (P>0.05) .On the first 4 th day and 7 th day, the decrease of the indicators of patients in A group was significantly better than group B patients, and the difference was statistically significant (P<0.05) .There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05) .Conclusion The application of large doses of short Ambroxol Hydrochloride Injection can quickly improve the clinical symptoms in acute exacerbation of elderly patients with chronic obstructive pulmonary disease, and reduce the patient's sputum IL-6, IL-8 and TNF-α index, has better anti-inflammatory effect and deserves wide application.
- Ambroxol /
- Elderly patients with chronic obstructive pulmonary disease /
- Inflammatory cytokines

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