不同剂量盐酸氨溴索注射液治疗老年慢性阻塞性肺疾病急性加重期患者对炎性细胞因子的影响

刘虎军; 高莉萍

不同剂量盐酸氨溴索注射液治疗老年慢性阻塞性肺疾病急性加重期患者对炎性细胞因子的影响

延安大学附属医院

基金项目:

基金：陕西省社会发展科技攻关项目 (2016SF-151);

计量
- 文章访问数: 2584
- HTML全文浏览量: 996
- PDF下载量: 58
- 被引次数: 0
出版历程
- 收稿日期: 2017-04-23

Influences of Different Doses of Ambroxol Hydrochloride Injection on Inflammatory Cytokines in Treatment of Elderly Patients with Chronic Obstructive Pulmonary Disease with Acute Exacerbation

Liu Hu Jun ,
Gao Li Ping

Funds:

基金：陕西省社会发展科技攻关项目 (2016SF-151);

摘要

摘要: 目的探讨采用不同剂量盐酸氨溴索注射液治疗老年慢性阻塞性肺疾病急性加重期患者对炎性细胞因子的影响.方法选取陕西延安大学附属医院2015年5月到2016年5月收治的62例慢性阻塞性肺疾病急性加重期患者, 将患者随机分为A组和B组, 每组各31例患者.为A组患者采用盐酸氨溴索注射液治疗, 每次330 mg, B组每日盐酸氨溴索注射液90 mg治疗, 对比2组患者第1天、第4天以及第7天痰液中IL-6、IL-8以及TNF-α指标.结果 2组患者入院治疗后第1天, 痰液中IL-6、IL-8以及TNF-α指标之间的差异相对较小, 不存在统计学意义 (P>0.05) .患者入院治疗第4天、第7天, A组患者各项指标下降速度均显著优于B组患者, 差异对比均存在统计学意义 (P<0.05) ;2组不良反应发生率差异没有统计学意义 (P>0.05) .结论短时间内应用大剂量盐酸氨溴索注射液, 能够快速降低老年慢性阻塞性肺疾病急性加重期患者的临床症状, 降低患者痰液中的IL-6、IL-8以及TNF-α指标, 具有较好的抗炎价值, 建议广泛应用.
- 盐酸氨溴索注射液 /
- 老年慢性阻塞性肺疾病 /
- 炎性细胞因子
Abstract: Objective To study the influences of different doses of Ambroxol Hydrochloride Injection on the inflammatory cotokines in the treatment of elderly patients with chronic obstructive pulmonary disease patients with acute exacerbation.Methods 62 cases of elderly patients with chronic obstructive pulmonary disease with acute exacerbation in our hospital from May 2015 to May 2016 were selected and randomly divided into Group A and B, 31 cases in each group.The Group A was given Ambroxol Hydrochloride Injection treatment, 330 mg per time, and Group B was given 90 mg Ambroxol Hydrochloride Injection treatment.The IL-6, IL-8, and TNF-α Index on the1 st day, 4 th day and 7 th day after the treatment in these two groups were compared.Results On the 1 st day, the sputum IL-6, IL-8 and TNF-αafter treatment had no statistically significant difference between two groups (P>0.05) .On the first 4 th day and 7 th day, the decrease of the indicators of patients in A group was significantly better than group B patients, and the difference was statistically significant (P<0.05) .There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05) .Conclusion The application of large doses of short Ambroxol Hydrochloride Injection can quickly improve the clinical symptoms in acute exacerbation of elderly patients with chronic obstructive pulmonary disease, and reduce the patient's sputum IL-6, IL-8 and TNF-α index, has better anti-inflammatory effect and deserves wide application.
- Ambroxol /
- Elderly patients with chronic obstructive pulmonary disease /
- Inflammatory cytokines

HTML全文

参考文献(15)

[1]柴燕玲, 王颖, 雷雯, 等.慢性阻塞性肺疾病继发肺部真菌感染相关因素分析[J].昆明医科大学学报, 2007, 28 (4) :141-142.[1]柴燕玲, 王颖, 雷雯, 等.慢性阻塞性肺疾病继发肺部真菌感染相关因素分析[J].昆明医科大学学报, 2007, 28 (4) :141-142.
[2]唐朝晖, 李永兰, 孟英龙, 等孟鲁斯特治疗对慢阻肺患者肺功能及Th1、Treg平衡的调节作用[J].湖南师范大学学报 (医学版) , 2016, 13 (1) :74-76.[2]唐朝晖, 李永兰, 孟英龙, 等孟鲁斯特治疗对慢阻肺患者肺功能及Th1、Treg平衡的调节作用[J].湖南师范大学学报 (医学版) , 2016, 13 (1) :74-76.
[3]梅涛, 贾若飞, 阙思伟, 等.纤支镜下大剂量盐酸氨溴索注射液灌洗治疗高血压重度脑出血后肺部感染[J].中国医药导刊, 2014, 16 (11) :1369-1370.[3]梅涛, 贾若飞, 阙思伟, 等.纤支镜下大剂量盐酸氨溴索注射液灌洗治疗高血压重度脑出血后肺部感染[J].中国医药导刊, 2014, 16 (11) :1369-1370.
[4]	[4]CLARA E GREEN, ALICE M TURNER.Role of chronic obstructive pulmonary disease in lung cancer pathogenesis[J].World Journal of Respirology, 2013, 11 (3) :67-76.[4]CLARA E GREEN, ALICE M TURNER.Role of chronic obstructive pulmonary disease in lung cancer pathogenesis[J].World Journal of Respirology, 2013, 11 (3) :67-76.
[5]	[5]MASAKI FUJITA.New therapies for chronic obstructive pulmonary disease, lung regeneration[J].World Journal of Respirology, 2015, 12 (1) :34-39.[5]MASAKI FUJITA.New therapies for chronic obstructive pulmonary disease, lung regeneration[J].World Journal of Respirology, 2015, 12 (1) :34-39.
[6]	[6]YUICHI TAKIGUCHI, IKUO SEKINE, SHUNICHIRO IWASAWA, ect.Chronic obstructive pulmonary disease as a risk factor for lung cancer[J].World Journal of Clinical Oncology, 2014, 23 (4) :660-666.[6]YUICHI TAKIGUCHI, IKUO SEKINE, SHUNICHIRO IWASAWA, ect.Chronic obstructive pulmonary disease as a risk factor for lung cancer[J].World Journal of Clinical Oncology, 2014, 23 (4) :660-666.
[7]胡晓慧.舒利迭联合噻托溴铵粉吸入剂对比舒利迭联合盐酸氨溴索注射液治疗慢性阻塞性肺疾病的临床疗效评价[J].中国煤炭工业医学杂志, 2015, 18 (11) :1859-1861.[7]胡晓慧.舒利迭联合噻托溴铵粉吸入剂对比舒利迭联合盐酸氨溴索注射液治疗慢性阻塞性肺疾病的临床疗效评价[J].中国煤炭工业医学杂志, 2015, 18 (11) :1859-1861.
[8]苏学会, 赵萍, 胡江涛, 等.COPD有创机械通气时用盐酸氨溴索注射液静脉注射及雾化吸入祛痰的疗效观察[J].河北医药, 2011, 33 (24) :3763-3764.[8]苏学会, 赵萍, 胡江涛, 等.COPD有创机械通气时用盐酸氨溴索注射液静脉注射及雾化吸入祛痰的疗效观察[J].河北医药, 2011, 33 (24) :3763-3764.
[9]陆首玲, 涂娟, 倪爱霞.异丙托溴铵、盐酸氨溴索注射液、普米克令舒联合雾化吸入治疗慢性阻塞性肺疾病急性加重期的疗效观察[J].现代诊断与治疗, 2014, 25 (13) :2959-2960.[9]陆首玲, 涂娟, 倪爱霞.异丙托溴铵、盐酸氨溴索注射液、普米克令舒联合雾化吸入治疗慢性阻塞性肺疾病急性加重期的疗效观察[J].现代诊断与治疗, 2014, 25 (13) :2959-2960.
[10]胡静珊, 谭文惠, 杨静萍.氨溴索雾化联合机械辅助排痰预防脑卒中卧床患者并发肺炎的效果观察[J].中国医药指南, 2014, 12 (30) :174-175.[10]胡静珊, 谭文惠, 杨静萍.氨溴索雾化联合机械辅助排痰预防脑卒中卧床患者并发肺炎的效果观察[J].中国医药指南, 2014, 12 (30) :174-175.
[11]	[11]JUDITH A BREBNER, ALICE M TURNER.Early chronic obstructive pulmonary disease:Beyond spirometry[J].World Journal of Respirology, 2013, 29 (3) :57-66.[11]JUDITH A BREBNER, ALICE M TURNER.Early chronic obstructive pulmonary disease:Beyond spirometry[J].World Journal of Respirology, 2013, 29 (3) :57-66.
[12]刘红梅, 马利军, 吴纪珍, 等.MSCs relieve lung injury of COPD mice through promoting proliferation of endogenous lung stem cells[J].Journal of Huazhong University of Science and Technology (Medical Sciences) , 2015, 22 (6) :828-833.[12]刘红梅, 马利军, 吴纪珍, 等.MSCs relieve lung injury of COPD mice through promoting proliferation of endogenous lung stem cells[J].Journal of Huazhong University of Science and Technology (Medical Sciences) , 2015, 22 (6) :828-833.
[13]王煜, 苏南湘, 陈泽奇, 等.Effects of Fengbaisan (丰白散) on the expression of matrix metalloproteinase—9 and tissue inhibitor of metalloproteinase-1 in lung tissue of rats with chronic obstructive pulmonary disease[J].Chinese Journal of Integrative Medicine, 2014, 19 (3) :224-231.[13]王煜, 苏南湘, 陈泽奇, 等.Effects of Fengbaisan (丰白散) on the expression of matrix metalloproteinase—9 and tissue inhibitor of metalloproteinase-1 in lung tissue of rats with chronic obstructive pulmonary disease[J].Chinese Journal of Integrative Medicine, 2014, 19 (3) :224-231.
[14]	[14]JOS M BORRO, MAR A DELGADO, ELISABETH COLL, Salvador Pita.Single-lung transplantation in emphysema:Retrospective study analyzing survival and waiting list mortality[J].World Journal of Transplantation, 2016, 2 (28) :347-355.[14]JOS M BORRO, MAR A DELGADO, ELISABETH COLL, Salvador Pita.Single-lung transplantation in emphysema:Retrospective study analyzing survival and waiting list mortality[J].World Journal of Transplantation, 2016, 2 (28) :347-355.
[15]古辉, 徐小彭.布地奈德氧气雾化吸入对慢阻肺急性发作期患者胸肺顺应性及气体交换参数的影响观察[J].临床医学工程, 2014, 21 (4) :461-462.[15]古辉, 徐小彭.布地奈德氧气雾化吸入对慢阻肺急性发作期患者胸肺顺应性及气体交换参数的影响观察[J].临床医学工程, 2014, 21 (4) :461-462.

相关文章(20)

[1]	李永菲, 张赟华, 高文分, 刘继华, 刘安彬, 杨玥娜. TOP-DOWN法评定盐酸氨溴索注射液含量测定的不确定度, 昆明医科大学学报.
[2]	李永菲, 高文分, 刘继华, 张赟华, 刘安彬, 杨玥娜. TOP-DOWN法评定盐酸氨溴索注射液含量测定的不确定度, 昆明医科大学学报.
[3]	卢金梅, 李玉柱, 王琳, 苏鑫, 林锦绣, 张建慧. 慢性阻塞性肺疾病患者基于可穿戴设备的肺康复效果研究, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20231127
[4]	刘和平, 吴鸿梅, 刘洋, 张春, 王伟舟, 游顶云, 武鸿翔. 慢性阻塞性肺疾病患者焦虑抑郁症状与CAT评分的相关性, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20201212
[5]	孙士波, 罗壮, 杜晓华, 杨娇, 业秀林, 张冬先, 杨为民. 血浆环指蛋白5检测在慢性阻塞性肺疾病中的意义, 昆明医科大学学报.
[6]	杨霞, 冯梅, 吴颖, 朱晶. 稳定期慢性阻塞性肺疾病中医肺康复治疗的疗效, 昆明医科大学学报.
[7]	王莉莉. 盐酸氨溴素注射液联合头孢哌酮钠舒巴坦治疗糖尿病合并肺炎患者临床症状及对肺功能的影响, 昆明医科大学学报.
[8]	王勤志, 李名武, 王锋. ShRNA-COX-2基因沉默对类风湿关节炎滑膜细胞的影响, 昆明医科大学学报.
[9]	李亚萍, 李永霞, 牛小群, 海冰, 曹宇, 柴燕玲. 吸烟与炎性因子在慢性阻塞性肺疾病急性加重期合并肺动脉高压中的相关性, 昆明医科大学学报.
[10]	海冰. DOSE指数评分系统在慢性阻塞性肺疾病中的应用价值, 昆明医科大学学报.
[11]	毕虹. 昆明地区慢性阻塞性肺疾病患者肺功能影响因素分析, 昆明医科大学学报.
[12]	胡伟华. 氨溴索对老年慢性阻塞性肺病急性加重期的疗效对比, 昆明医科大学学报.
[13]	陈敏. 大剂量盐酸氨溴索在慢性阻塞性肺疾病急性加重患者治疗中的临床价值, 昆明医科大学学报.
[14]	贺小玉. 慢性阻塞性肺疾病患者SAA及IP-10与炎性因子水平相关性分析, 昆明医科大学学报.
[15]	苏慧鹏. 老年慢性阻塞性肺疾病患者踝-臂脉搏波传导速度、踝臂指数的相关性, 昆明医科大学学报.
[16]	曾海萍. 超常规剂量氨溴索治疗慢性阻塞性肺疾病疗效及安全性的系统评价, 昆明医科大学学报.
[17]	董昭兴. HRCT划分慢性阻塞性肺疾病不同表型的临床特征观察, 昆明医科大学学报.
[18]	林少芳. 90例老年慢性阻塞性肺疾病合并自发性气胸治疗体会, 昆明医科大学学报.
[19]	朱迎霞. 康复治疗对慢性阻塞性肺疾病稳定期BODE指数及预后的影响, 昆明医科大学学报.
[20]	. 慢性阻塞性肺疾病合并肺栓塞的临床分析, 昆明医科大学学报.