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小鼠胚胎脑源与脊髓源神经干细胞增殖能力的比较

赵瑜 袁婧 刘建军 鲁琳

熊萍, 罗君, 刘彦. 单端固定桥修复上下颌磨牙10年的回顾性研究[J]. 昆明医科大学学报, 2019, 40(10): 57-61.
引用本文: 赵瑜, 袁婧, 刘建军, 鲁琳. 小鼠胚胎脑源与脊髓源神经干细胞增殖能力的比较[J]. 昆明医科大学学报, 2017, 38(09): 19-23.
Zhao Yu , Yuan Jing , Liu Jian Jun , Lu Lin . Comparison of Proliferation between Fetal Forebrain-and Spinal Cord-Derived Neural Stem Cells in Mice[J]. Journal of Kunming Medical University, 2017, 38(09): 19-23.
Citation: Zhao Yu , Yuan Jing , Liu Jian Jun , Lu Lin . Comparison of Proliferation between Fetal Forebrain-and Spinal Cord-Derived Neural Stem Cells in Mice[J]. Journal of Kunming Medical University, 2017, 38(09): 19-23.

小鼠胚胎脑源与脊髓源神经干细胞增殖能力的比较

基金项目: 

基金: 云南省应用基础研究基金资助项目 (2014C039Y);

Comparison of Proliferation between Fetal Forebrain-and Spinal Cord-Derived Neural Stem Cells in Mice

Funds: 

基金: 云南省应用基础研究基金资助项目 (2014C039Y);

  • 摘要: 目的 探讨小鼠前脑源和脊髓源神经干细胞 (NSCs) 的增殖能力差异.方法 选择孕14 d C57BL胎鼠, 机械分离法从前脑和脊髓分离培养神经干细胞, Nestin/Sox2免疫荧光染色鉴定NSCs.计算细胞倍增速率 (Multiplication rate) 和细胞倍增时间 (Cell doubling time) , Brd U/Nestin双标检测NSCs增殖.结果 由C57BL胎鼠前脑和脊髓分离得到的细胞群, 均可在体外分裂增殖形成神经球, Nestin&Sox2标记阳性.脑源NSCs增殖速度显著高于脊髓源 (P<0.05) , 而倍增时间则与增殖能力成反比;P5代时两种干细胞增殖最快;Nestin&Brd U双标的NSCs也证明了正在增殖的脑源NSCs (29.65±3.38) %显著多于脊髓源的NSCs (19.93±1.95) % (P<0.05) .结论 来源于前脑的NSCs增殖能力更强.
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