儿童急性淋巴细胞白血病化疗后的不良反应
Adverse Reactions in Children with Acute Lymphoblastic Leukemia after Chemotherapy
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摘要: 目的 分析儿童急性淋巴细胞白血病化疗后不良反应发生的特点及规律, 实施个体化给药避免或减少严重的药品不良反应 (ADR) 的发生.方法 收集2014年3月至2015年2月新发儿童急性淋巴细胞白血病化疗后不良反应184 3例, 对患者性别, 年龄, 危险度、药物、ADR累及器官或系统等方面进行研究分析.结果儿童急性淋巴细胞白血病化疗后不良反应涉及高危组患者居多;涉及药物以左旋门冬酰胺酶、长春新碱、阿糖胞苷居前3位;不良反应累及的系统或器官以血液系统最为常见;骨髓抑制并发感染与危险度及患儿年龄差异有统计学意义 (P<0.01) , 与性别无统计学差异 (P>0.05) .结论 儿童急性淋巴细胞白血病化疗后ADR以骨髓抑制最为常见, 其中以骨髓抑制及并发感染对患儿生活质量及治疗效果的影响最大.Abstract: Objective To analyse the characteristics of adverse reactions in children with acute lymphoblastic leukemia after chemotherapy, and to implement individualized medication to avoid or reduce the occurrence of serious adrs. Methods The report on the adverse reactions in children with acute lymphoblastic leukemia after chemotherapy from 2015.2 to 2014.3 was collected, the patient gender, age, risk, drug and ADR involving organs or systems were analyzed. Results The adverse reactions in children with acute lymphoblastic leukemia after chemotherapy are involved mostly in the high-risk group of patients. L-asparaginase, vincristine and cytarabine were the top three drugs involved in adverse reactions. Blood system was the most common system involved in adverse reactions. Bone marrow suppression concurrent infection had significant difference between different risks and ages (P < 0.01) had no statistical difference between different genders (P > 0.05) . Conclusion Bone marrow suppression was the most common ADR in children with acute lymphoblastic leukemia after chemotherapy, and bone marrow suppression and concurrent infection have the greatest influence on the quality of life and the treatment effect of children.
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Key words:
- Children /
- ALL /
- Adverse reactions
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