金钗石斛化学成分和药理作用研究进展
Advances in Researches of Chemical Components and Pharmacological Effect from Dendrobium nobile Lindl
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摘要: 查阅2010年至2017年国内外学者对金钗石斛化学成分及药理作用的相关文献报道, 分析金钗石斛国内外研究进展.金钗石斛的化学成分主要包括生物碱、倍半萜、联苄、芴酮、酚酸、苯丙素、菲、多糖、木脂素类化合物.近年来, 金钗石斛的研究主要侧重于化学成分、药理作用以及栽培技术的研究, 随着分离技术以及提取工艺的进步, 将来可能会更倾向于相关制剂、化妆品和保健品的开发和利用.Abstract: To summarize and analyse the research condition, progress and area of studies on Dendrobium nobile by investigating domestic and foreign literatures about chemical constitutes and pharmacological effects from2010 to 2017. Dendrobium nobile Lindl is a sort of medicinal plant which mainly contains alkaloids, sesquiterpene, binenzyls, fluorenone, phenolic acid, lignin, phenylpropanoid, phenanthrenes, polysaccharide etc. Recently, the researches of Dendrobium nobile is mainly concentrated on chemical compounds, pharmacological effect and the cultivation techniques. In the forthcoming researches, utmost importance may be attached to the development and utilization of the relevant preparations, cosmetics as well as health care products.
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Key words:
- Dendrobium nobile lindl /
- Chemical constituents /
- Pharmacological effect
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[1]陈志辉, 罗明, 魏刚, 等.不同产地金钗石斛HPLC特征图谱的比较[J].广东药学院学报, 2014, 30 (6) :707-712. [2]HONG X U, ZHENGTAO WANG.Dendrobium nobile, Lindl.石斛 (Shihu, Dendrobium) [M].Dietary Chinese Herbs.Springer Vienna, 2015:597-604. [3] [3]CHEN X M, XIAO S Y, GUO S X.Comparison of chemical compositions between Dendrobium candidum and Dendrobium nobile[J].Acta Academiae Medicinae Sinicae, 2006, 28 (4) :524. [4] [4]LIU N, SUN Z R, LIAO X K, et al.Mass fraction variation of alkaloids and polysaccharides in Dendrobium nobile Lindl with Different Harvest Time[J].Journal of Jilin University, 2010, 48 (3) :511-515. [5] [5]LIU H, DONG H L.Optimization of the extraction technology of total alkaloids from Dendrobium nobil by Ultrasonic Assisted Method[J].Hubei Agricultural Sciences, 2013, 27 (8) :845-9. [6]赵福坤, 吴芹, 陆远富, 等.金钗石斛总生物碱提取及含量测定方法的改进[J].遵义医学院学报, 2015, 38 (05) :532-535. [7] [7]ZHANG X, LIU H, GAO H, et al.Nine New Sesquiterpenes from Dendrobium nobile[J].Helvetica Chimica Acta, 2010, 90 (12) :2386-2394. [8]肖世基, 钱怡, 张良, 等.黔产金钗石斛中1个新的杜松烷型倍半萜[J].中草药, 2016, 47 (17) :2972-2974. [9] [9]ZHOU X M, ZHENG C J, GAN L S, et al.Bioactive phenanthrene and bibenzyl derivatives from the stems of Dendrobium nobile[J].Journal of Natural Products, 2016, 79 (7) :1791-1797. [10] [10]XIAO S J, ZHEN L, ZHANG M S, et al.A new bibenzyl compound from Dendrobium nobile[J].Acta Pharmaceutica Sinica, 2016, 51 (07) :1117-1120. [11] [] [12] [] [13] [13]ZHOU X M, ZHENG C J, WU J T, et al.Five new lactone derivatives from the stems of Dendrobium nobile[J].Fitoterapia, 2016, 115 (12) :96-100. [14] [14]ZHOU X, ZHENG C, GAN L, et al.Bioactive phenanthrene and bibenzyl derivatives from the stems of Dendrobium nobile[J].Journal of Natural Products, 2016, 79 (7) :1791-1797. [15]姚晓东, 朱锡敏, 张渊, 等.金钗石斛不同储存期多糖组分、总多糖含量及分子量分布的变化 (英文) [J].遵义医学院学报, 2015, 38 (4) :341-345. [16]姚晓东, 刘章泉, 汪巍, 等.金钗石斛水溶性多糖分子量分布及单糖组份分析 (英文) [J].遵义医学院学报, 2015, 38 (3) :239-243. [17] [17]ZHOU X M, ZHENG C J, WU J T, et al.A new phenolic glycoside from the stem of Dendrobium nobile[J].Natural Product Research, 2017, 31 (9) :1042-1046. [18] [18]YI Z, WANG H, PENG W, et al.Optimization of PEG-based extraction of polysaccharides from Dendrobium nobile Lindl and bioactivity study[J].International Journal of Biological Macromolecules, 2016, 92 (7) :1057-1066. [19] ZHANG X.Antioxidant phenanthrenes and lignans from Dendrobium nobile[J].中国药学 (英文版) , 2008, 17 (4) :314-318. [20]郑家欢, 吴观健, 吴岳滨, 等.GC-MS分析金钗石斛花挥发油成分[J].中药材, 2016, 39 (08) :1797-1799. [21]陆礼和, 杜艳妮, 张艳, 等.金钗石斛营养成分分析研究[J].云南师范大学学报 (自然科学版) , 2013, 33 (01) :60-63. [22]张晓敏, 孙志蓉, 陈龙, 等.金钗石斛的化学成分和药理作用研究进展[J].中国现代应用药学, 2014, 31 (7) :895-899. [23]姜琳珊, 李菲, 聂晶, 等.金钗石斛总生物碱对APP/PS1转基因小鼠学习记忆能力的影响[J].遵义医学院学报, 2016, 39 (03) :246-249. [24]王丽娜, 龚其海, 李菲, 等.金钗石斛多糖减轻脂多糖诱导的大鼠学习记忆减退及机制研究[J].神经药理学报, 2016, 6 (01) :1-8. [25]王丽娜, 张明辉, 李菲, 等.金钗石斛多糖对脂多糖诱导的大鼠海马APP和GSK-3β基因的影响[J].中国处方药, 2014, 12 (11) :114-115. [26]张玮, 胡娟, 吴芹, 等.金钗石斛生物总碱对β淀粉样蛋白25-35片段所致PC12细胞损伤的保护作用[J].遵义医学院学报, 2015, 38 (04) :346-349. [27]张明辉, 李菲, 张玮, 等.金钗石斛总生物碱对Aβ- (25-35) 所致大鼠海马组织Aβ含量的影响[J].遵义医学院学报, 2016, 39 (01) :18-21. [28]林牧, 龚其海, 吴芹, 等.金钗石斛多糖对脂多糖作用大鼠皮层胶质细胞-神经元体系的保护作用[J].中国药理学通报, 2016, 32 (08) :1144-1148. [29]詹剑, 李小琼, 郝仁方.金钗石斛多糖对局灶性脑缺血-再灌注大鼠的作用[J].中国脑血管病杂志, 2017, 14 (01) :25-31. [30]李小琼, 詹剑, 冯赞杰, 等.金钗石斛多糖减轻大鼠脑缺血再灌注损伤[J].中成药, 2017, 39 (04) :677-683. [31]詹剑, 李小琼, 郝仁方.金钗石斛多糖上调锌指蛋白A20表达减轻大鼠缺血性脑损伤[J].中风与神经疾病杂志, 2017, 34 (04) :332-335. [32]杨城, 陈莹, 金海, 等.金钗石斛对慢性疲劳综合征大鼠行为学的改善作用[J].遵义医学院学报, 2017, 40 (01) :49-52. [33]安祯祥, 何远利, 陈昱江, 等.金钗石斛多糖对肝纤维化大鼠肝功能损伤治疗作用及机制探讨[J].时珍国医国药, 2016, 27 (8) :1865-1867. [34]刘庆春.金钗石斛对糖尿病大鼠肾组织PKC和TGF-β_1表达的影响[J].光明中医, 2017, 32 (07) :957-958. [35]刘园园, 张艳磊, 何晓然, 等.金钗石斛水煎剂对糖尿病肾病大鼠肾脏PPARγ表达的影响[J].医药导报, 2014, 33 (12) :1545-1548. [36]金徽, 陶凤, 唐彦萍.金钗石斛对糖尿病肾病大鼠肾组织NF-κB、IL-6表达的影响[J].重庆医学, 2014, 43 (08) :946-948. [37]黄琦, 廖鑫, 吴芹, 等.金钗石斛生物总碱对糖尿病大鼠血糖及肝脏组IRS-2m RNA, IGF-1 m RNA表达的影响[J].中国实验方剂学杂志, 2014, 20 (19) :155-158. [38]葛晓军, 郑丽梅, 王永伦, 等.金钗石斛多糖对髓系白血病细胞WT1基因表达的影响[J].重庆医学, 2015, 44 (10) :1305-1307. [39] [] [40] [40]KIM J H, OH S Y, HAN S B, et al.Anti-inflammatory effects of Dendrobium nobile derived phenanthrenes in LPS-stimulated murine macrophages[J].Archives of Pharmacal Research, 2015, 38 (6) :1117-1126. [41] [41]ZHANG Z Y, YANG C M, LAN Z, et al.Study on the Value of Polysaccharide in Dendrobium Candidum in Antibacterial Action[J].Guide of China Medicine, 2012, 10 (33) :439-440.
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