足量美托洛尔缓释片治疗冠心病的临床观察
Clinical Observation on Treatment of Coronary Heart Disease Angina by Enough Metoprolol
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摘要: 目的 观察足量应用美托洛尔缓释片治疗冠心病的临床疗效、耐受性和安全性.方法 将临床确诊为冠心病的98例患者随机分为2组, 实验组在常规冠心病二级预防的药物基础上加用美托洛尔缓释片治疗, 在4周内逐渐加量至最大耐受剂量, 对照组采用常规冠心病二级药物治疗, 对所有患者进行门诊随访半年, 观察患者心率、血压、心绞痛发作频率、心功能及心电图改善情况.对比2组的临床治疗效果.结果 实验组临床疗效明显优于对照组, 2组间比较, 差异有统计学意义 (P<0.05) .结论 足量应用美托洛尔缓释片能显著改善冠心病患者的临床症状.Abstract: Objective To observe the effect, toleration and safety of metoprolol in treatment of coronary heart disease angina.Methods Ninety-eight patients with confirmed coronary heart disease were randomly divided into two groups:control group and metoprolol treatment group.Patients in the metoprolol treatment group were given metoprolol sustained release tablet treatment on the basis of regular drug treatment, and the dosage of metoprolol was increased gradually to the maximum tolerated dose.Patients in the control group were given regular drug treatment.All patients were followed up for half a year.The heart rate, blood pressure, the frequency of the angina attack, cardiac function and ECG were observed to compare the clinical effect between two groups.Results The clinical effect in the metoprolol treatment group was significantly better than the control group.There were statistically significant difference between control group and metoprolol treatment group (P<0.05) .Conclusion Enough metoprolol sustained release tablets can significantly improve the clinical symptoms of coronary heart disease.
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