恒古骨伤愈合剂对骨质疏松骨折树鼩雌二醇和骨代谢的影响
Effects of Osteoking on Estradiol and Bone Metabolism of Tree Shrews with Osteoporotic Fracture
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摘要: 目的 观察恒古骨伤愈合剂对骨质疏松骨折树血清雌二醇和骨代谢指标的影响.方法 骨质疏松骨折树随机分为用药组和对照组, 用药组实验树按体重100 g每2 d灌服恒古骨伤愈合剂0.3 mL, 对照组实验树按相同剂量灌服生理盐水.实验树灌服90 d, 心脏采血分离血清, 应用ELISA试剂盒检测血清中E2、OC、PINP、CTX、TRACP-5b的含量.结果 用药组实验树血清E2含量 (145.16±21.76) 显著高于对照组 (30.78±4.22) , P<0.05, 血清OC (1546.67±219.07) 、PINP (10.02±1.76) 、CTX (176.47±24.56) 、TRACP-5b (1249.06±194.87) 分别显著低于对照组 (2792.96±387.23) 、 (28.74±4.05) 、 (324.67±41.32) 、 (2106.36±322.99) , P<0.05.结论 恒古骨伤愈合剂能够引起骨质疏松骨折树雌二醇和骨代谢指标的变化, 说明有一定的疗效.Abstract: Objective To observe the effects of Osteoking on serum estradiol and bone metabolism index of tree shrew with osteoporotic fracture.Methods Tree shrews with osteoporotic fracture were randomly divided into treatment group and control group.The tree shrews in treatment group were given 0.3 mL of Osteoking by 100 g body weight every two days for 90 days, while the tree shrews in the control group were given the same dose of saline.The serum samples were collected from the heart.The contents of E2, OC, PINP, CTX and TRACP-5 b were measured by ELISA kit.Results The serum E2 content of tree shrews in the treatment group was significantly higher than the control group (145.16±21.76 vs 30.78±4.22) (P<0.05) , the serum OC (1546.67±219.07) , PINP (10.02±1.76) , CTX (176.47±24.56) , TRACP-5 b (1249.06±194.87) in the treatment group were significantly lower than the control group (2792.96±387.23) and (28.74±4.05) , (324.67±41.32) , (2106.36±322.99) (P<0.05) .Conclusion Osteoking can cause changes in estradiol and bone metabolism index of tree shrews with osteoporotic fracture, indicating it has a certain effect
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Key words:
- Osteoking /
- Osteoporosis /
- Fracture /
- Tree shrew /
- Estradiol /
- Bone metabolism
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[1]胡敏, 王兵, 赵宏斌, 等.恒古骨伤愈合剂预防性给药对股骨颈骨折术后半年股骨头坏死发生率及负重髋疼痛程度的影响[J].中国临床康复, 2005, 9 (14) :158-159. [2]赵宏斌, 胡敏, 邱智兴, 等.恒古骨伤愈合剂治疗腰椎间盘突出症37例长期疗效观察[J].云南中医中药杂志, 2006, 27 (5) :3-4. [3]周兆文, 普有登, 袁晓峰, 等.恒古骨伤愈合剂治疗急性腰扭伤的疗效观察[J].云南医药, 2012, 33 (5) :435-436. [4] [4]YOUNG P A.Treeshrews, the primitive primate mammals for medical experimental animals[J].Int'l J Mol Zoo, 2011, 1 (2) :4-6. [5]杨凤, 李燕皎, 王运林, 等.手术双侧卵巢去势法建立骨质疏松树模型[J].昆明医科大学学报, 2016, 37 (1) :24-27. [6]中国老年学学会骨质疏松委员会.中国人骨质疏松症诊断标准专家共识 (第三稿2014版) [J].中国骨质疏松杂志, 2014, 20 (9) :1007-1010. [7]吴婷婷, 屈会化, 胡丽娜, 等.基于树体表面积的树与人类及其它实验动物等效剂量换算系数的测算[J].中华中医药杂志, 2015, 30 (1) :203-205. [8]孙岩, 陈冉, 王小琦, 等.恒古骨伤愈合剂对去势雌性大鼠骨质疏松模型的影响[J].中国骨质疏松杂志, 2016, 22 (12) :1513-1515. [9]李冠慧, 李灿东, 李西海, 等.雌激素调控绝经后骨质疏松症骨吸收-骨形成耦联失衡的机制[J].中医正骨, 2016, 28 (2) :36-39. [10]薛吴罡, 冷冰, 马恩元, 等.雌激素水平与绝经女性并发骨质疏松症的相关性研究[J].中国妇幼保健, 2011, 26 (26) :4106-4108. [11]李丹, 孙文艳, 李晶, 等.老年骨质疏松患者骨折与骨代谢标志物的相关性研究[J].临床医药实践, 2015, 24 (7) :500-504. [12] [12]KLINGBERG E, NURKKALA M, CARLSTEN H, et al.Biomarkers of bone metabolism in ankylosing spondylitis in relation to osteoproliferation and osteoporosis[J].J Rheumatol, 2014, 41 (7) :1349-1356. [13]樊险峰, 黄兴华, 黄运咏, 等.鲑鱼降钙素治疗骨质疏松症的疗效及对骨代谢标志物水平的影响[J].海南医学院学报, 2015, 21 (8) :1137-1139. [14]黄继红, 李溥, 任一, 等.鹿角壮骨胶囊对去卵巢骨质疏松大鼠骨细微结构及骨代谢影响的实验研究[J].基层医学论坛, 2016, 20 (7) :865-868. [15]孔西建, 吴丹, 叶进, 等.益肾活血法对原发性骨质疏松症患者骨密度、骨代谢及脆性骨折发生率的影响[J].中医杂志, 2014, 55 (5) :391-395. [16]覃裕, 邱冰, 朱思刚, 等.仙灵骨葆胶囊治疗骨质疏松症的疗效及其对骨代谢及骨转换指标的影响分析[J].中国骨质疏松杂志, 2015, 21 (9) :1056-1060. [17]刘冬梅, 袁林, 苏林冲, 等.强骨康疏胶囊对去卵巢骨质疏松症模型大鼠细胞因子的影响[J].中国免疫学杂志, 2014, 30 (3) :338-341. -
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