恒古骨伤愈合剂对骨质疏松骨折树鼩雌二醇和骨代谢的影响
Effects of Osteoking on Estradiol and Bone Metabolism of Tree Shrews with Osteoporotic Fracture
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摘要: 目的 观察恒古骨伤愈合剂对骨质疏松骨折树血清雌二醇和骨代谢指标的影响.方法 骨质疏松骨折树随机分为用药组和对照组, 用药组实验树按体重100 g每2 d灌服恒古骨伤愈合剂0.3 mL, 对照组实验树按相同剂量灌服生理盐水.实验树灌服90 d, 心脏采血分离血清, 应用ELISA试剂盒检测血清中E2、OC、PINP、CTX、TRACP-5b的含量.结果 用药组实验树血清E2含量 (145.16±21.76) 显著高于对照组 (30.78±4.22) , P<0.05, 血清OC (1546.67±219.07) 、PINP (10.02±1.76) 、CTX (176.47±24.56) 、TRACP-5b (1249.06±194.87) 分别显著低于对照组 (2792.96±387.23) 、 (28.74±4.05) 、 (324.67±41.32) 、 (2106.36±322.99) , P<0.05.结论 恒古骨伤愈合剂能够引起骨质疏松骨折树雌二醇和骨代谢指标的变化, 说明有一定的疗效.Abstract: Objective To observe the effects of Osteoking on serum estradiol and bone metabolism index of tree shrew with osteoporotic fracture.Methods Tree shrews with osteoporotic fracture were randomly divided into treatment group and control group.The tree shrews in treatment group were given 0.3 mL of Osteoking by 100 g body weight every two days for 90 days, while the tree shrews in the control group were given the same dose of saline.The serum samples were collected from the heart.The contents of E2, OC, PINP, CTX and TRACP-5 b were measured by ELISA kit.Results The serum E2 content of tree shrews in the treatment group was significantly higher than the control group (145.16±21.76 vs 30.78±4.22) (P<0.05) , the serum OC (1546.67±219.07) , PINP (10.02±1.76) , CTX (176.47±24.56) , TRACP-5 b (1249.06±194.87) in the treatment group were significantly lower than the control group (2792.96±387.23) and (28.74±4.05) , (324.67±41.32) , (2106.36±322.99) (P<0.05) .Conclusion Osteoking can cause changes in estradiol and bone metabolism index of tree shrews with osteoporotic fracture, indicating it has a certain effect
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Key words:
- Osteoking /
- Osteoporosis /
- Fracture /
- Tree shrew /
- Estradiol /
- Bone metabolism
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