右美托咪定对重度颅脑创伤大鼠脑水肿程度的影响

李正超; 钱传云; 吴海鹰; 张玮; 夏婧

右美托咪定对重度颅脑创伤大鼠脑水肿程度的影响

昆明医科大学第一附属医院急诊医学科EICU

基金项目:

基金：云南省教育厅科学研究基金资助项目 (2014J043);

计量
- 文章访问数: 2452
- HTML全文浏览量: 864
- PDF下载量: 88
- 被引次数: 0
出版历程
- 收稿日期: 2017-03-01

Effect of Dexmedetomidine on Brain Edema in Rats with Severe Traumatic Brain Injury

Funds:

基金：云南省教育厅科学研究基金资助项目 (2014J043);

摘要

摘要: 目的研究右美托咪定对重度颅脑创伤 (TBI) 后大鼠大脑水肿程度的影响.方法制作SD大鼠颅脑创伤模型, 并使用右美托咪定进行治疗干预, 观察72 h内大鼠神经功能损害程度、脑组织含水量和BBB通透性的变化.结果不同组TBI大鼠各时间点NSS评分:主体内效应差异有统计学意义 (P=0.041) , 主体间效应差异有统计学意义 (P<0.001) ;不同组TBI大鼠各时间点脑组织含水量:主体内效应差异有统计学意义 (P=0.032) , 主体间效应差异有统计学意义 (P<0.001) ;神经功能评分和脑水肿程度具有相关性 (r=0.61, P<0.001) 结论 TBI大鼠脑水肿高峰为TBI后24 h;TBI大鼠在损伤早期使用右美托咪定镇静治可降低BBB通透性及减轻大鼠脑组织水肿, 从而促进神经功能恢复.
- 颅脑创伤脑水肿 /
- 右美托咪定 /
- AQP4
Abstract: Objective To study the effect of dexmedetomidine on brain edema in rats with severe traumatic brain injury (TBI) .Methods SD rat traumatic brain injury model was established and was treated with dexmedetomidine.The changes of neurological impairment, brain water content and BBB permeability were observed within 72 hours after injury.Results The NSS score of different TBI rats in different groups:the difference of internal effect was statistically significant (P=0.041) , and the difference between subjects was statistically significant (P<0.001) .The water content of the brain tissue in different groups of TBI rats was statistically significant (P=0.032) , and the difference between subjects was statistically significant (P<0.001) .The correlation was found between neurological score and cerebral edema degree (r=0.61, P<0.001) .Conclusions TBI rat cerebral edema peaks at 24 h after TBI.Dexmedetomidine can reduce BBB permeability and reduce the edema of TBI rats in the early stage of injury, thereby promoting the recovery of nerve function.
- Traumatic brain injury /
- Brain edema /
- Dexmedetomidine

HTML全文

参考文献(20)

[1]	[1]BADAUTJ, ASHWALS, ADAMIA, et al.Brain water mobility decreases after astrocytic aquaporin-4 inhibition using RNA interference[J].Journal of Cerebral Blood Flow&Metabolism, 2010, 31 (3) :819-831.
[2]	[2]ISOARDO G AND I MORRA.Different aquaporin-4 expression in glioblastoma multiforme patients with and without seizures[J].Molecular Medicine, 2012, 18 (7) :1-4.
[3]	[3]SONG Y, GUNNARSON E.Potassium dependent regulation of astrocyte water permeability is mediated by c AMPSignaling[J].PLo S ONE, 2012, 7 (4) :349-356.
[4]高峰, 闫玉仙, 毕海涛等.脑外伤后继发性损伤研究现状[J].武警后勤学院学报 (医学版) , 2013, 22 (12) :1120-1122.
[5]刘永亮, 王鹏与李建民.颅脑损伤后脑水肿的发病机制研究进展[J].中国医药指南, 2013, (8) :76-78.
[6]	[6]BADAUT J, FUKUDA A M, JULLIENNE A, et al.Aquaporin and brain diseases[J].Biochim Biophys Acta, 2014, 1840 (5) :1554-1556.
[7]沈礼芹, 蒋金泉与郭建杰, 脑挫裂伤后脑组织中AQP4的表达变化及意义[J].山东医药, 2011, 51 (26) :6-8.
[8]	[8]MCCOY E, SONTHEIMER H.MAPK induces AQP1 expression in astrocytes following injury[J].Glia, 2010, 8 (2) :209-217.
[9]	[9]HEMPHILL M A, DABIRI B E, GABRIELE S, et al.A Possible Role for Integrin Signaling in Diffuse Axonal Injury[J].PLo SONE, 2011, 6 (7) :228-231.
[10]	[10]SELLMANN T, MIERSCH D, KIENBAUM P, et al.The impact of arterial hypertension on polytrauma and traumatic brain injury[J].Dtsch Arztebl Int, 2012, 109 (49) :849-855.
[11]	[11]TERPOLILLINA, KIMS, THAL S C, et al.Inhaled nitric oxide reduces secondary brain damage after traumatic brain injury in mice[J].Journal of Cerebral Blood Flow&Metabolism, 2012, 33 (2) :311-318.
[12]	[12]HARRIS J L, YEHH, CHOII, et al.Altered neurochemical profile after traumatic brain injury:1H-MRS biomarkers of pathological mechanisms[J].Journal of Cerebral Blood Flow&Metabolism, 2012, 32 (12) :2122-2124.
[13]	[13]DEVABHAKTHUNIS, PAJOUMANDM, WILLIAMS C, et al.Evaluation of dexmedetomidine:Safety and clinical outcomes in critically Ill Trauma patients[J].The Journal of Trauma:Injury, Infection, and Critical Care, 2011, 71 (5) :1164-1171.
[14]	[14]HOYLE J J, CALLAHANJM, BADAWYM, et al.Pharmacologicalsedation for cranialcomputedtomography in childrenafterminorbluntheadtrauma[J].Pediatr Emerg Care, 2014, 30 (1) :1-7.
[15]	[15]LOPIZZO, SCHIERAG, DILIEGRO, et al.Aquaporin-4distribution in control and stressed astrocytes in culture and in the cerebrospinal fluid of patients with traumatic brain injuries[J].Neurological Sciences, 2015, 34 (8) :1309-1314.
[16]	[16]FUKUDA A M, BADAUT J.Aquaporin 4:a player in cerebral edema and neuroinflammation[J].Journal of Neuroinflammation, 2016, 9 (1) :279.
[17]	[17]BOUTST, TAYLORP, BERRYK, et al.Evaluation of medetomidine-ketamine and dexmedetomidine-ketamine in Chinese water deer (Hydropotesinermis) [J].Veterinary Anaesthesia and Analgesia, 2014, 38 (2) :106-112.
[18]	[18]KONG L, LIAN G, ZHENG W, et al.Effect of alcohol on diffuse axonal injury in rat brainstem:Diffusion tensor imaging and aquaporin-4 expression study[J].Bio Med Research International, 2013, 20 (13) :1-9.
[19]	[19]SHENAQM, HERRYJ, TAYLORH, et al.Neuronal damage and functional deficits are ameliorated by inhibition of aquaporin and HIF1αafter traumatic brain injury (TBI) [J].Journal of the Neurological Sciences, 2016, 323 (2) :134-140.
[20]	[20]BENGGONM, CHENH, APPLEGATE R, et al.Effect of dexmedetomidine on brain edema and neurological outcomes in surgical brain injury in rats[J].Anesthesia&Analgesia, 2015, 115 (1) :154-159.

相关文章(20)

[1]	包红梅, 秦榕, 张宇, 杨美菊, 苏纲. PCV-VG模式联合右美托咪定对腹腔镜袖状胃切除术患者术中呼吸力学和血气指标的影响, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20240917
[2]	赵玲, 角述兰, 思永玉, 杨柳, 卜莹慧. 右美托咪定在不同程度烧伤患者体内的药代动力学研究, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230725
[3]	秦榕, 苏纲, 张宇, 殷巍, 赵震. 右美托咪定联合甲磺酸多拉司琼对腹腔镜袖状胃切除术患者血浆胃动素及术后恶心呕吐的影响, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230215
[4]	鲁月, 邱昌明, 杨云丽, 黄治国, 李治贵, 麻伟青, 李娜. 超声引导下右美托咪定作为佐剂的罗哌卡因单次收肌管阻滞用于成人髌骨骨折术后镇痛的效果, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220613
[5]	彭丽佳, 杨渊, 郭然, 熊莉, 李俊杰, 邵建林, 曾卫军. 右美托嘧啶联合纳布啡用于脑膜瘤手术对患者术后认知功能的影响, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210306
[6]	冯兆森, 方育, 欧顶琴, 杨轶涵, 王志瑶, 黄洁. 右美托咪定和地塞米松作为臂丛神经阻滞添加剂的临床疗效, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20211005
[7]	杨渊, 彭丽佳, 浦澜青, 李俊杰, 邵建林, 杨鑫. 丙泊酚复合右美托咪定或咪达唑仑在老年人无痛胃肠镜检中的应用, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210221
[8]	曹艳, 蒋鸿雁, 王艳雪, 吴抖威, 钱传云, 吴海鹰, 李坪. 右美托咪定抑制大鼠创伤性脑损伤后神经细胞凋亡, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210202
[9]	杨麦巧, 张富荣, 刘丽丽, 刘晓颖, 刘萍. 右美托咪定防治腰硬联合麻醉下剖宫产术中寒战的临床效果, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20201125
[10]	杨柳, 屈启才, 陈瑞, 角述兰, 思永玉, 周华. 右美托咪定对烟雾吸入性肺损伤大鼠炎症反应的影响, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20201124
[11]	熊青青, 罗晓东, 付步芳, 钟家依, 和国莲. 右美托咪定对高海拔地区全麻手术患者术后呼吸的影响, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20201224
[12]	王刚, 张磊, 周娟, 郭涛. 持续输入小剂量右美托咪定对老年髋关节置换术后谵妄的影响, 昆明医科大学学报.
[13]	杨玥, 陶建平. 右美托咪定的临床麻醉应用进展, 昆明医科大学学报.
[14]	王兴耀, 陈建春, 屈启才, 欧阳杰, 马军, 周臣. 不同剂量右美托咪定在老年患者局麻疝修补术中的镇静效果, 昆明医科大学学报.
[15]	李文锋, 范晓华, 董发团, 李娜. 右美托咪定对平稳拔除气管导管时七氟烷半数有效浓度的影响, 昆明医科大学学报.
[16]	宋仕钦. 右美托咪定对老年手术患者氧合功能及心肺功能的影响, 昆明医科大学学报.
[17]	吴海鹰. ICU镇静对危重症患者谵妄发生的影响, 昆明医科大学学报.
[18]	单可记. 右美托咪定联合氯胺酮麻醉诱导困难气道插管, 昆明医科大学学报.
[19]	. 右美托咪定在气管插管中对循环系统及丙泊酚用量的影响, 昆明医科大学学报.
[20]	. 右美托咪定对抑制经鼻气管插管反应的临床观察, 昆明医科大学学报.