尘螨变应原皮内试验与血清IgE检测结果的相关性

程晟; 余咏梅; 崔云华; 徐学梅; 邱吉蔚

尘螨变应原皮内试验与血清IgE检测结果的相关性

昆明医科大学第一附属医院耳鼻喉科

基金项目:

基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2014FZ024);

计量
- 文章访问数: 1852
- HTML全文浏览量: 635
- PDF下载量: 64
- 被引次数: 2
出版历程
- 收稿日期: 2017-05-14

Correlation Analysis of Dust Mite Allergen between Intradermal Test and Serum Specific IgE Test

Funds:

基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2014FZ024);

摘要

摘要: 目的探讨变应性鼻炎粉尘螨及户尘螨变应原体内检测与体外检测的相关关系.方法选择变应性鼻炎患者34例, 体内检测采用皮内试验法, 体外检测采用血清特异性IgE检测法, 根据皮内试验结果分为:极强阳性组、强阳性组、中阳性组、阳性组及阴性组5个级别;应用Excel软件进行统计分析.结果粉尘螨、户尘螨变应原皮内试验分别与体外血清lgE检测具有高度相关性;变应原皮内试验 (即户尘螨与粉尘螨的平均值) 与IgE检测具有高度相关性, 相关系数r=0.8532 (P<0.01, n=20) .结论粉尘螨和户尘螨变应原皮内试验与体外血清lgE检测具有高度相关性, 临床上可以在患者条件允许的情况下先做皮内试验作为筛查, 然后再用体外检测进一步验证;对于高敏患者或其他不接受皮内试验的患者, 可直接进行体外检测.
- 尘螨变应原 /
- 皮内试验 /
- 体外检测 /
- 相关关系
Abstract: Objective To analze the correlation of dust mite allergen between intradermal test and serum specific IgE test in allergic rhinitis.Methods We selected 20 patients with allergic rhinitis, and used intradermal test and serum specific SIgE test to test dust mite allergen.The intradermal test results were divided into:extremely strong positive group, strong positive group, middle positive group, positive group and negative group.Excel was used to make statistical analysis.Results Dust mites, house dust mites allergen intradermal test, respectively, had a significant correlation with serum SIgE test;intradermal test (the mean of house dust mites and dust mite) also had a significant correlation with serum SIgE test.The correlation index r=0.8532 (P <0.01, n=20) .Conclusions Mites allergen intradermal test has a significant correlation with serum SIgE test.If permitted, we can first do intradermal test as a screening, and then use SIgE test as a further verification;for high-sensitive patients or other patients who do not accept intradermal test, we can directly use serum SIgE test.
- Dust mite allergen /
- Intradermal test /
- Serum SIgE test /
- Correlation

HTML全文

参考文献(20)

[1]	[1]BOUSQUET J, KHALTAEV N, CRUZ A A, et al.Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the world health organization, GA (2) LEN and Aller Gen[J].Allergy, 2012, 5 (Suppl 3) :S212-217.
[2]	[2]ASHER M I, MONTEFORT S, BJORKSTEN B, et al.Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood:ISAAC Phases One and Three repeat multicountry cross-sectional surveys[J].Lancet, 2006, 368 (9537) :733-743.
[3]	[3]LI J, SUN B, HUANG Y, et al.A multicentre study assessing the prevalence of sensitizations in patients with asthma and/or rhinitis in China[J].Allergy, 2009, 64 (7) :1083-1092.
[4]	[4]DE GROOT E P, NIJKAMP A, DUIVERMAN EJ, et al.Allergic rhinitis is associated with poor asthma control in children with asthma[J].Thorax, 2012, 67 (7) :582-587.
[5]	[5]BACHERT C, VAN CAUWENBEERGE P.The WHO ARIA (allergic rhinitis and its impact on asthma) initiative[J].Chem Immunol Allergy, 2003, 82 (3) :119-126.
[6]尤少华, 李玉茹, 刘扬, 等.吸入性变应原皮肤点刺试验与血清特异性Ig E抗体检测的比较研究[J].中国现代医学杂志, 2014, 24 (4) :42-45.
[7]	[7]POSA D, HOFMAIER S, ARASI S, et al.Natural evolution of Ig E responsesto mite allergens and relationship to progression of allergic disease:a review[J].Curr Allergy Asthma Rep, 2017, 17 (5) :28.
[8]中华耳鼻咽喉科学会.变应性鼻炎诊断及疗效评定标准 (1997年修订, 海口) [J].中华耳鼻咽喉科杂志, 1998, 33 (3) :134-135.
[9]乔秉善.变态反应学实验技术[M].第2版.北京:中国协和医科大学出版社, 2002:103-105.
[10]钟志美, 郑传东, 王方, 等.尘螨主要变应原蛋白的Ig E结合表位序列分析[J].南方医科大学学报, 2011, 31 (7) :1183-1186.
[11]韩玉清, 俞黎黎, 周鹰, 等.尘螨变应原Derf 6/p ET32a (+) 重组质粒构建、表达、纯化及其产物血清Ig E结合率[J].中国免疫学杂志, 2017, 33 (1) :76-80.
[12]	[12]BOUSQUET J, LOCKEY R, MALLING H J.Allergen immunotherapy:therapeutic vaccines for allergic disease.A WHO position paper[J].J Allergy Clin Immunol, 1998, 102 (3) :558-562.
[13]	[13]STEMESEDER T, SCHWEIDLER B, DOPPLER P, et al.Exposure to indoor allergens in different residential settings and its influence on Ig E sensitization in a geographically confined austrian cohort[J].PLo S One, 201, 12 (1) :e0168686.
[14]	[14]POSA D, PERNA S, RESCH Y, et al.Evolution and predictive value of Ig E responses toward acomprehensive panel of house dust mite allergens during the first 2 decades of life[J].J Allergy Clin Immunol, 2017, 139 (2) :541-549.
[15]	[15]BECKER S, SCHLEDERER T, KRAMER MF, et al.Real-life study for the diagnosis of house dust mite allergythe value of recombinant allergen-based Ig E serology[J].Int Arch Allergy Immunol, 2016, 170 (2) :132-137.
[16]江万进, 纪东, 桂晓钟, 等.小儿变应性鼻炎症状与尘螨特异性Ig E及家居环境尘螨变应原含量相关性分析[J].中国耳鼻咽喉头颈外科, 2016, 23 (1) :41-43.
[17]许晨霞, 张妙莲, 邹泽红, 等.螨制剂舌下免疫治疗对单一和多重致敏变应性鼻炎的疗效评估[J].中华临床免疫和变态反应杂志, 2014, 8 (2) :95-100.
[18]	[18]OKANO H, FUJIMURA T, FUKUOKA N, et al.Plasma cluster Ions reduce the Ig E-binding capacity of house dust mite allergens under a Simulated Indoor Environmental Condition[J].Int Arch Allergy Immunol, 2017, 173 (4) :199-203.
[19]	[19]DOUGLASS J A, O’HEHIR R E, Diagnosis treatment and prevention of allergic disease:the basics[J].Med J, 2006, 158 (4) :228-233.
[20]翟月明, 陈蕴光, 赖荷, 等.变应性鼻炎变应原皮肤检测与体外检测的相关关系[J].现代医学, 2010, 10 (4) :64-65.

相关文章(20)

[1]	陆霓虹, 刘洪璐, 陈杨君, 孙娅萍, 杨艳, 杨永锐, 李杰. ESAT-6联合多项检测指标评估抗结核药物性肝损伤严重程度的关系, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20240808
[2]	张锦丽, 梅佳华, 廖承成, 胡丹, 黄虹, 李元文. 促渗剂对八桂止痛乳膏体外经皮吸收的影响, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220623
[3]	葛哲, 卢思萍, 付仕忠, 王春红, 李少莹, 刘翺. 全血γ-干扰素释放试验联合T淋巴细胞亚群检测在肺结核诊断中的初步应用, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210901
[4]	肖成, 谭建玲, 李江, 李薇, 许广芳, 徐应芳. 新生儿ABO溶血病与血液检测指标相关性的分析, 昆明医科大学学报.
[5]	刘洋, 黄娅娟, 廖婧, 孙春意, 翟淑娟, 周红林. 宫颈病变中应用FISH技术检测C-MYC基因及HC2技术、SPR技术检测HPV结果的相关性, 昆明医科大学学报.
[6]	庞波, 李娟. 外周血miR相关指标在矽肺患者中的检测价值, 昆明医科大学学报.
[7]	冉震, 朱云莎, 海冰, 张劲松. 肿瘤组织内肿瘤浸润淋巴细胞和前列腺癌术后复发的关系, 昆明医科大学学报.
[8]	王春龙, 韩丹, 文亮. 间皮素与肿瘤诊治的相关研究进展, 昆明医科大学学报.
[9]	廖然超, 余咏梅, 邱吉蔚, 徐学梅. 昆明地区过敏性鼻炎及哮喘患者家庭优势尘螨种类调查, 昆明医科大学学报.
[10]	蔡仁慧, 赵新湘. 心梗后心肌瘢痕的DE-MRI检测及其与室性心律失常关系的研究现状, 昆明医科大学学报.
[11]	姚寒曦. HtrA1 及其相关因子MGP、BMP-2 在人牙周膜细胞体外成骨分化和矿化过程中的动态表达, 昆明医科大学学报.
[12]	张晋煜. 经皮椎体成形术联合内固定治疗多节段脊柱转移癌, 昆明医科大学学报.
[13]	杨萍. 体外心脏震波治疗对冠心病患者血管再生相关细胞因子的影响, 昆明医科大学学报.
[14]	李俊彦. 七叶皂苷对体外培养大鼠神经元生长的作用及其与BDNF的关系, 昆明医科大学学报.
[15]	周明利. 应用DSA和MRA检测糖尿病患者颅内血管病变的临床意义, 昆明医科大学学报.
[16]	周明利. 应用DSA和MRA检测糖尿病患者颅内血管病变的临床意义, 昆明医科大学学报.
[17]	李智. 微创经皮钢板内固定治疗高能量胫骨上段骨折, 昆明医科大学学报.
[18]	黄颖. 人脐带间充质干细胞对再生障碍性贫血患者T细胞相关因子调节的体外研究, 昆明医科大学学报.
[19]	. 腭裂相关基因TTF-2转基因小鼠载体的构建及体外表达, 昆明医科大学学报.
[20]	. 昆明市城区皮肤过敏花粉的调查研究, 昆明医科大学学报.