Abstract: Objective To analyze the clinical characteristics of dengue fever accompanied withthrombocytopenia, in order to enhance the clinician's further understanding of the disease.Methods The 64 cases of dengue fever treated in the third people's Hospital of Kunming during June 2012 to January 2016 were divided into two groups with thrombocytopenia and without thrombocytopenia.The clinical and laboratory data were compared and analyzed.Results Between patients with and without thrombocytopenia, the gender, age and the highest temperature had no significant difference (P >0.05) ;the duration of fever had statistically significant difference (P<0.05) ;The clinical manifestations, subcutaneous bleeding, gastrointestinal bleeding, nasal hemorrhage had statistically significant difference between two groups of patients (P >0.05) .There were statistically significant differences in the laboratory results in WBC, NE, PLT, AST and LDH levels between two groups of patients (P<0.05) .in the thrombocytopenia group, 26 cases (74.29%) had liver injury, and 17 cases (58.62%) had liver damage in the non thrombocytopenia group.The difference of AST/ALT ratio between the 2 groups was statistically significant (P <0.05) .Con clusions Early stage of dengue fever accompanied by thrombocytopenia is prone to lead to bleeding and tissue and organ damage, so it should be paid attention to early in the disease, so as to prevent the progression of hemorrhagic fever or shock syndrome.