催产素镇痛机制的研究进展

罗雅范; 李国萍; 陈绍春; 韩毅

催产素镇痛机制的研究进展

1. 昆明医科大学基础医学院人体解剖与组织胚胎学系
2. 昆明医科大学第三附属医院头颈外科
3. 昆明医科大学国际教育学院
4. 昆明医科大学基础医学院生理学系

基金项目:

作者简介：韩毅, 男, 49岁, 副教授, 硕士研究生导师.1993年毕业于昆明医学院临床医学专业, 现为昆明医科大学基础医学院副院长, 云南省生理科学会理事长、中国生理学会理事.专业方向为循环生理、神经生理;研究方向为心肌缺血的信号通路研究、痛觉调制及镇痛机制研究.主持云南省科技厅-昆明医科大学联合项目1项, 参与国家自然科学基金项目3项、云南省科技厅-昆明医科大学联合重点项目1项.近年来发表论文10余篇, 其中SCI收录论文7篇.E-mail:kmhanyi@163.com; 罗雅范 (1992~) , 女, 四川雅安市人, 在读硕士研究生, 主要从事镇痛机制研究工作.; 陈绍春.E-mail:shaochunchen@126.com;

基金：国家自然科学基金资助项目 (81260195, 81302362);

计量
- 文章访问数: 1892
- HTML全文浏览量: 562
- PDF下载量: 150
- 被引次数: 0
出版历程
- 收稿日期: 2017-09-12

The Advanced Progress on the Analgesic Mechanism of Oxytocin

Funds:

基金：国家自然科学基金资助项目 (81260195, 81302362);

摘要

摘要: 催产素 (oxytocin, OT) 是哺乳动物体内产生的一种九肽激素, 大部分在下丘脑室旁核和视上核合成, 少量在外周器官中合成.催产素的主要功能是促进排乳和使子宫收缩, 除此之外还有很多生理功能, 如镇痛作用.大量研究证明神经肽具有明显的镇痛作用, 而哺乳动物自然分泌的催产素, 就是一种神经肽.已有研究证明催产素具有较强的镇痛作用, 而且可以避免常规镇痛药物的成瘾性等不良反应, 但其镇痛的确切机制尚不明确, 所以研究催产素的镇痛机制具有较强的基础和临床意义.
- 催产素 /
- 镇痛 /
- 机制
Abstract: Oxytocin (OT) is a 9-amino-peptide hormone synthesized mainly in the Paraventricular Nucleus (PVN) and Supraoptic Nucleus (SON) of mammals’hypothalamus.Small part of OT is synthesized in peripheral organs.In addition to promoting the lactation and uterine contraction, OT has many other physiological functions, such as analgesia.It has been proved that neuropeptide can exert analgesic effect.OT is indeed a neuropeptide secreted naturally by mammals.Sdudies have shown that OT plays an important role in relieving pain and can avoid problems like addiction and other side effects.However, its underlying mechanism of analgia is still unclear.Therefore, further study of the analgesic mechanism of oxytocin has a great theoretic significance and very broad clinical prosperities.
- Oxytocin /
- Analgesia /
- Mechanism

HTML全文

参考文献(23)

[1]刘柳, 汪晴川, 盖冬玮, 等.利鲁唑在神经保护、镇痛及抗抑郁领域的研究进展[J].化学与生物工程, 2017, 34 (2) :6-9.
[2]刘超斌, 王梅英, 李东舫.催产素的研究进展[J].中华妇产科杂志, 1999, 34 (5) :55-57.
[3]	[3]OHMICHI M, OIKE K, NOHARA A, et al.Oxytocin stimulates mitogen-activated protein kinase activity in cultured human puerperal uterine myometrial cells[J].Endocrinology, 1995, 136 (5) :2082-2087.
[4]	[4]KU C, QIAN A, WEN Y, et al.Oxytocin stimulates myometrial guanosine triphosphatase and phospholipase-Cactivities via coupling to G alpha q/11[J].Endocrinology, 1995, 136 (4) :1509-1515.
[5]	[5]GAO L, YU C.Involvement of opioid receptors in the oxytocin-induced antinociception in the central nervous system of rats[J].Regulatory Peptides, 2004, 120 (1-3) :53-58.
[6]	[6]YANG J, YANG Y, CHEN M, et al.Central oxytocin enhances antinociception in the rat[J].Peptides, 2007, 28 (5) :1113-1119.
[7]	[7]MADRAZO I, FRANCO-BOURLAND R, LEON-MEZAV M, et al.Intraventricular somatostatin-14, arginine vasopressin, and oxytocin:analgesic effect in a patient with intractable cancer pain[J].Stereot actic&Functional Neurosurgery, 1987, 50 (1-6) :427-431.
[8]	[8]YANG J.Intrathecal administration of oxytocin induces analgesia in low back pain involving the endogenous opiate peptide system[J].Spine, 1994, 19 (8) :867-871.
[9]	[9]S.Q.YU, T.LUNDEBERG, L.C.YU.Involvement of oxytocin in spinal antinociception in rats with inflammation[J].Brain Research, 2003, 983 (12) :13-22.
[10]	[10]CHOW L H, TAO P L, CHEN J C, et al.A possible correlation between oxytocin-induced and angiotensin IV-induced anti-hyperalgesia at the spinal level in rats[J].Peptides, 2013, 39 (1) :21-28.
[11]	[11]ROJASPILONI G, GERARDO R P, MEJIARODRIGUEZR, et al.Oxytocin, but not vassopressin, modulates nociceptive responses in dorsal horn neurons[J].Neuroscience Letters, 2010, 476 (1) :32-35.
[12]	[12]OODIN B R, NESS T J, ROBBINS M T.Oxytocin Amultifunctional analgesic for chronic deep tissue pain[J].Current Pharmaceutical Design, 2015, 21 (7) :906-913.
[13]	[13]MARTINEZ-LORENZANA G, ESPINOSALOSALOPEZ I, CARRANZA M, et al.PVN electrical stimulation prolongs withdrawal latencies and releases oxytocin in cerebrospinal fluid, plasma, and spinal cord tissue in intact and neuropathic rats[J].Pain, 2008, 140 (2) :265-273.
[14]	[14]TACHE Y, CHOW L H, CHEN Y H, et al.Sex difference in oxytocin-induced anti-hyperalgesia at the spinal level in rats with intraplantar carrageenan-induced inflammation[J].Plos One, 2016, 11 (9) :e0162218.
[15]	[15] ELIAVA M, MELCHIOR M, KNOBLOCH-BOLLMANNH S, et al.A new population of parvocellular oxytocin neurons controlling magnocellular neuron activity and inflammatory pain processing[J].Neuron, 2016, 89 (6) :1291-1304.
[16]高庆军, 孟凡竹, 刘巍, 等.催产素在侧脑室内对正常大鼠的镇痛作用[J].中国妇幼保健, 2014, 29 (31) :5154-5157.
[17]	[17]HUBER D, VEINANTE P, STOOP R.Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala.[J].Science, 2005, 308 (5719) :245-248.
[18]	[18]BRETON J D, POISBEAU P, DARBON P.Antinociceptive action of oxytocin involves inhibition of potassium channel currents in lamina II neurons of the rat spinal cord[J].Molecular Pain, 2009, 5 (1) :63-74.
[19]	[19]JIANG C Y, FUJITA T, KUMAMOTO E.Synaptic modulation and inward current produced by oxytocin in substantia gelatinosa neurons of adult rat spinal cord slices[J].Journal of Neurophysiology, 2014, 111 (5) :991-1007.
[20]	[20]HOBO S, HAYASHIDA K, EISENACH J C.Oxytocin inhibits the membrane depolarization-induced increase in intracellular calcium in capsaicin sensitive sensory neurons:a peripheral mechanism of analgesic action[J].Anesthesia&Analgesia, 2012, 114 (2) :442-449.
[21]	[21]TZABAZIS A, MECHANIC J, MILLER J, et al.Oxytocin receptor:Expression in the trigeminal nociceptive system and potential role in the treatment of headache disorders[J].Cephalalgia An International Journal of Headache, 2015, 36 (10) :943-950.
[22]	[22]RADDANT A C, RUSSO A F.Calcitonin gene-related peptide in migraine:intersection of peripheral inflammation and central modulation[J].Expert Reviews in Molecular Medicine, 2011, 13 (201) :e36.
[23]	[23]ELIAVA M, MELCHIOR M, KNOBLOCH-BOLLMANNH S, et al.A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing[J].Neuron, 2016, 89 (6) :1291-1304.

相关文章(20)

[1]	张露, 李叶, 王晴晴, 李生浩. 肝硬化对心血管系统的影响及相关机制研究进展, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20240601
[2]	彭煜航, 李焱娟, 曲婧红, 唐代欢, 张宏伟, 吴睿, 徐世莲. 大鼠伏核甘丙肽镇痛作用及其机制, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230925
[3]	鲁月, 邱昌明, 杨云丽, 黄治国, 李治贵, 麻伟青, 李娜. 超声引导下右美托咪定作为佐剂的罗哌卡因单次收肌管阻滞用于成人髌骨骨折术后镇痛的效果, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220613
[4]	郭云瑞, 杨建明, 杨皓, 张业才, 张国云, 周臣, 侯亚婷. 镇静、镇痛慢诱导气管插管对全身麻醉患者血流动力学及心理影响, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210906
[5]	刘少星, 谢先丰, 曹德钧. 不同镇痛模式在幼儿疝气修补术后早期镇痛的临床效果, 昆明医科大学学报.
[6]	张立, 董介轩, 殷志荣, 石小东, 李皎, 许燕飞, 刘维统, 董玮. 针刀松解对坐骨神经痛大鼠中枢镇痛机制, 昆明医科大学学报.
[7]	刘旺生, 王金鸿, 黄欢. PCEA联合规律间断注入联合不同剂量罗哌卡因对产妇分娩镇痛效果及母婴结局的影响, 昆明医科大学学报.
[8]	徐永玄, 杨萍, 郭涛. 房颤发生机制及治疗新进展, 昆明医科大学学报.
[9]	徐成, 黄晓霞, 范锟铻, 周利枚, 周广芳. N₂O吸入镇痛对吸入性损伤兔呼吸功能的影响, 昆明医科大学学报.
[10]	陆元元, 龙婷, 冯蕾, 刘维超, 李国晖, 吴雷. 痛风气雾剂治疗急性痛风性关节炎的用药综合护理, 昆明医科大学学报.
[11]	黄赛君, 葛菲, 陈文林, 李云茜, 谭林彦, 王曦. MMP-1在乳腺癌脑转移中的作用研究进展, 昆明医科大学学报.
[12]	李红阳, 苏天义, 龚建平, 甘平, 杨步荣, 寸英丽, 查勇, 赵公芳. 缺血后处理对裸鼠肝脏缺血再灌注损伤的保护作用及其机制, 昆明医科大学学报.
[13]	唐帮丽. 脐带间充质干细胞移植治疗狼疮性肾炎的疗效与机制, 昆明医科大学学报.
[14]	刘清华. 丙泊酚联合舒芬太尼对腹腔镜子宫肌瘤剔除术的镇痛、苏醒及不良反应的影响, 昆明医科大学学报.
[15]	董忠礼. 单核巨噬细胞促进静脉血栓机化再通的机制及研究进展, 昆明医科大学学报.
[16]	贾楠楠. Gnaq对SH-SY5Y细胞增殖的作用及机制, 昆明医科大学学报.
[17]	张美琼. 剖宫产手术孕妇不同镇痛方式的镇痛效果观察, 昆明医科大学学报.
[18]	李翠林. 罗哌卡因或左布比卡因复合舒芬太尼用于分娩镇痛的临床比较, 昆明医科大学学报.
[19]	邵建林. HO-1对氧糖剥夺海马神经元线粒体运动调节蛋白的影响, 昆明医科大学学报.
[20]	文德才. 硬膜外持续给药镇痛方法在无痛分娩中的应用, 昆明医科大学学报.