催产素镇痛机制的研究进展

罗雅范; 李国萍; 陈绍春; 韩毅

催产素镇痛机制的研究进展

1. 昆明医科大学基础医学院人体解剖与组织胚胎学系
2. 昆明医科大学第三附属医院头颈外科
3. 昆明医科大学国际教育学院
4. 昆明医科大学基础医学院生理学系

基金项目:

作者简介：韩毅, 男, 49岁, 副教授, 硕士研究生导师.1993年毕业于昆明医学院临床医学专业, 现为昆明医科大学基础医学院副院长, 云南省生理科学会理事长、中国生理学会理事.专业方向为循环生理、神经生理;研究方向为心肌缺血的信号通路研究、痛觉调制及镇痛机制研究.主持云南省科技厅-昆明医科大学联合项目1项, 参与国家自然科学基金项目3项、云南省科技厅-昆明医科大学联合重点项目1项.近年来发表论文10余篇, 其中SCI收录论文7篇.E-mail:kmhanyi@163.com; 罗雅范 (1992~) , 女, 四川雅安市人, 在读硕士研究生, 主要从事镇痛机制研究工作.; 陈绍春.E-mail:shaochunchen@126.com;

基金：国家自然科学基金资助项目 (81260195, 81302362);

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出版历程
- 收稿日期: 2017-09-12

The Advanced Progress on the Analgesic Mechanism of Oxytocin

Funds:

基金：国家自然科学基金资助项目 (81260195, 81302362);

摘要

摘要: 催产素 (oxytocin, OT) 是哺乳动物体内产生的一种九肽激素, 大部分在下丘脑室旁核和视上核合成, 少量在外周器官中合成.催产素的主要功能是促进排乳和使子宫收缩, 除此之外还有很多生理功能, 如镇痛作用.大量研究证明神经肽具有明显的镇痛作用, 而哺乳动物自然分泌的催产素, 就是一种神经肽.已有研究证明催产素具有较强的镇痛作用, 而且可以避免常规镇痛药物的成瘾性等不良反应, 但其镇痛的确切机制尚不明确, 所以研究催产素的镇痛机制具有较强的基础和临床意义.
- 催产素 /
- 镇痛 /
- 机制
Abstract: Oxytocin (OT) is a 9-amino-peptide hormone synthesized mainly in the Paraventricular Nucleus (PVN) and Supraoptic Nucleus (SON) of mammals’hypothalamus.Small part of OT is synthesized in peripheral organs.In addition to promoting the lactation and uterine contraction, OT has many other physiological functions, such as analgesia.It has been proved that neuropeptide can exert analgesic effect.OT is indeed a neuropeptide secreted naturally by mammals.Sdudies have shown that OT plays an important role in relieving pain and can avoid problems like addiction and other side effects.However, its underlying mechanism of analgia is still unclear.Therefore, further study of the analgesic mechanism of oxytocin has a great theoretic significance and very broad clinical prosperities.
- Oxytocin /
- Analgesia /
- Mechanism

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参考文献(23)

[1]刘柳, 汪晴川, 盖冬玮, 等.利鲁唑在神经保护、镇痛及抗抑郁领域的研究进展[J].化学与生物工程, 2017, 34 (2) :6-9.
[2]刘超斌, 王梅英, 李东舫.催产素的研究进展[J].中华妇产科杂志, 1999, 34 (5) :55-57.
[3]	[3]OHMICHI M, OIKE K, NOHARA A, et al.Oxytocin stimulates mitogen-activated protein kinase activity in cultured human puerperal uterine myometrial cells[J].Endocrinology, 1995, 136 (5) :2082-2087.
[4]	[4]KU C, QIAN A, WEN Y, et al.Oxytocin stimulates myometrial guanosine triphosphatase and phospholipase-Cactivities via coupling to G alpha q/11[J].Endocrinology, 1995, 136 (4) :1509-1515.
[5]	[5]GAO L, YU C.Involvement of opioid receptors in the oxytocin-induced antinociception in the central nervous system of rats[J].Regulatory Peptides, 2004, 120 (1-3) :53-58.
[6]	[6]YANG J, YANG Y, CHEN M, et al.Central oxytocin enhances antinociception in the rat[J].Peptides, 2007, 28 (5) :1113-1119.
[7]	[7]MADRAZO I, FRANCO-BOURLAND R, LEON-MEZAV M, et al.Intraventricular somatostatin-14, arginine vasopressin, and oxytocin:analgesic effect in a patient with intractable cancer pain[J].Stereot actic&Functional Neurosurgery, 1987, 50 (1-6) :427-431.
[8]	[8]YANG J.Intrathecal administration of oxytocin induces analgesia in low back pain involving the endogenous opiate peptide system[J].Spine, 1994, 19 (8) :867-871.
[9]	[9]S.Q.YU, T.LUNDEBERG, L.C.YU.Involvement of oxytocin in spinal antinociception in rats with inflammation[J].Brain Research, 2003, 983 (12) :13-22.
[10]	[10]CHOW L H, TAO P L, CHEN J C, et al.A possible correlation between oxytocin-induced and angiotensin IV-induced anti-hyperalgesia at the spinal level in rats[J].Peptides, 2013, 39 (1) :21-28.
[11]	[11]ROJASPILONI G, GERARDO R P, MEJIARODRIGUEZR, et al.Oxytocin, but not vassopressin, modulates nociceptive responses in dorsal horn neurons[J].Neuroscience Letters, 2010, 476 (1) :32-35.
[12]	[12]OODIN B R, NESS T J, ROBBINS M T.Oxytocin Amultifunctional analgesic for chronic deep tissue pain[J].Current Pharmaceutical Design, 2015, 21 (7) :906-913.
[13]	[13]MARTINEZ-LORENZANA G, ESPINOSALOSALOPEZ I, CARRANZA M, et al.PVN electrical stimulation prolongs withdrawal latencies and releases oxytocin in cerebrospinal fluid, plasma, and spinal cord tissue in intact and neuropathic rats[J].Pain, 2008, 140 (2) :265-273.
[14]	[14]TACHE Y, CHOW L H, CHEN Y H, et al.Sex difference in oxytocin-induced anti-hyperalgesia at the spinal level in rats with intraplantar carrageenan-induced inflammation[J].Plos One, 2016, 11 (9) :e0162218.
[15]	[15] ELIAVA M, MELCHIOR M, KNOBLOCH-BOLLMANNH S, et al.A new population of parvocellular oxytocin neurons controlling magnocellular neuron activity and inflammatory pain processing[J].Neuron, 2016, 89 (6) :1291-1304.
[16]高庆军, 孟凡竹, 刘巍, 等.催产素在侧脑室内对正常大鼠的镇痛作用[J].中国妇幼保健, 2014, 29 (31) :5154-5157.
[17]	[17]HUBER D, VEINANTE P, STOOP R.Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala.[J].Science, 2005, 308 (5719) :245-248.
[18]	[18]BRETON J D, POISBEAU P, DARBON P.Antinociceptive action of oxytocin involves inhibition of potassium channel currents in lamina II neurons of the rat spinal cord[J].Molecular Pain, 2009, 5 (1) :63-74.
[19]	[19]JIANG C Y, FUJITA T, KUMAMOTO E.Synaptic modulation and inward current produced by oxytocin in substantia gelatinosa neurons of adult rat spinal cord slices[J].Journal of Neurophysiology, 2014, 111 (5) :991-1007.
[20]	[20]HOBO S, HAYASHIDA K, EISENACH J C.Oxytocin inhibits the membrane depolarization-induced increase in intracellular calcium in capsaicin sensitive sensory neurons:a peripheral mechanism of analgesic action[J].Anesthesia&Analgesia, 2012, 114 (2) :442-449.
[21]	[21]TZABAZIS A, MECHANIC J, MILLER J, et al.Oxytocin receptor:Expression in the trigeminal nociceptive system and potential role in the treatment of headache disorders[J].Cephalalgia An International Journal of Headache, 2015, 36 (10) :943-950.
[22]	[22]RADDANT A C, RUSSO A F.Calcitonin gene-related peptide in migraine:intersection of peripheral inflammation and central modulation[J].Expert Reviews in Molecular Medicine, 2011, 13 (201) :e36.
[23]	[23]ELIAVA M, MELCHIOR M, KNOBLOCH-BOLLMANNH S, et al.A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing[J].Neuron, 2016, 89 (6) :1291-1304.

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