Q开关Nd:YAG治疗在色素性皮肤病中的疗效及对黑素代谢的影响

丁祖烈; 陈滔; 李盛华

Q开关Nd:YAG治疗在色素性皮肤病中的疗效及对黑素代谢的影响

攀枝花学院附属医院整形美容科

基金项目:

基金：国家自然科学基金资助项目 (81172832);

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出版历程
- 收稿日期: 2017-08-11

The Observation on the Effect of Q-Switching Nd:YAG Treatment in Pigmented Dermatoses and Influence for Melanin Metabolism

Funds:

基金：国家自然科学基金资助项目 (81172832);

摘要

摘要: 目的观察Q开关Nd:YAG治疗在色素性皮肤病中的疗效及对黑素代谢的影响程度.方法选取2015年10月至2016年8月期间攀枝花学院附属医院收治的114例色素性皮肤病患者为研究对象, 将114例患者随机分为对照组57例和观察组57例.对照组采用强脉冲光治疗, 观察组在对照组的基础上加用Q开关Nd:YAG治疗.比较2组患者临床总有效率、复发率、不良反应发生率、治疗前后的皮损评分、血清黑素代谢相关指标.结果观察组的临床总有效率高于对照组 (P<0.05) , 复发率低于对照组 (P<0.05) , 而2组的不良反应发生率比较, 差异无统计学意义 (P>0.05) , 治疗前2组患者的皮损评分及血清黑素代谢相关指标比较, 差异无统计学意义 (P>0.05) , 治疗后观察组的皮损评分及血清黑素代谢相关指标均好于对照组 (P<0.05) .结论 Q开关Nd:YAG治疗在色素性皮肤病中的临床疗效较好, 且对黑素代谢的影响更为积极, 因此在色素性皮肤病的治疗中具有较高的临床价值.
- Q开关Nd:YAG治疗 /
- 色素性皮肤病 /
- 临床疗效 /
- 黑素代谢 /
Abstract: Objective To observe the effect of Q-Switching Nd:YAG treatment in pigmented dermatoses and its influence for melanin metabolism. Methods 114 patients with pigmented dermatoses in our hospital from October 2015 to August 2016 were selected as the study object, and were randomly divided into the control group (57 cases) and the observation group (57 cases) .The control group were treated with intense pulsed light therapy while the observation group were treated with Q-Switching Nd:YAG treatment on the treatment of control group.Then the total effective rates, recurrence rates, adverse reaction rates, skin lesion scores and serum melanin metabolism related indexes before and after the treatment of two groups were analyzed and compared. Results Clinically, the total effective rates of observation group were higher than those of control group (P<0.05) and the recurrence rate of observation group was lower than that of control group (P<0.05) .The adverse reaction rates of two groups were compared and the differences were not statistically significant ( P >0.05) .The skin lesion scores and serum melanin metabolism related indexes of two groups before the treatment were compared and the differences were not statistically significant (P>0.05) .The serum melanin metabolism related indexes of two groups after the treatment were all better than those of control group ( P <0.05) . Conclusion The clinical effect of Q-Switching Nd:YAG treatment in the patients with pigmented dermatoses is better, and it has the active influence for the melanin metabolism, so it has higher clinical value in the treatment of pigmented dermatoses.
- Q-Switching Nd /
- YAG treatment /
- Pigmented dermatoses /
- Clinical effect /
- Melanin metabolism

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参考文献(17)

[1]李俞晓, 韩婷梅, 郭晓光, 等.大光斑低能量Q开关Nd:YAG激光联合化瘀祛斑胶囊治疗黄褐斑疗效观察[J].中国美容医学, 2015, 24 (16) :36-39.
[2]林辉, 文清, 张晶晶, 等.大光斑低能量Q开关Nd:YAG激光联合中药面膜治疗黄褐斑疗效观察[J].中国皮肤性病学杂志, 2016, 30 (9) :958-960.
[3]马少吟, 程军平, 王艳芳, 等.Q开关Nd:YAG激光联合谷胱甘肽、维生素C治疗黄褐斑疗效分析[J].国际皮肤性病学杂志, 2013, 39 (2) :83-85.
[4]杨菁, 张正中, 牟韵竹, 等.Q开关Nd:YAG激光治疗色素性皮肤病239例临床疗效观察[J].皮肤病与性病, 2013, 35 (5) :281-282.
[5]佘文莉, 黄海玲, 刘晖, 等.Q开关nd:YAG激光治疗皮肤色素性病变术前术中局部冰敷效果评估[J].广东医学, 2013, 34 (4) :648-649.
[6]	[6]KWON H H, OHN J, SUH D H, et al.A pilot study for triple combination therapy with a low-fluence 1064?nm Q-switched Nd:YAG laser, hydroquinone cream and oral tranexamic acid for recalcitrant Riehl's Melanosis[J].J Dermatolog Treat, 2017, 28 (2) :155-159.
[7]施学清.血府逐瘀胶囊联合激光治疗黄褐斑的临床疗效及对黑素指数的影响[J].黑龙江医药, 2016, 29 (1) :107-108.
[8]应为红, 张理梅, 李嫦嫦.中药祛斑霜对黄褐斑豚鼠模型皮肤中SOD、MDA和黑素颗粒的影响[J].上海中医药杂志, 2017, 51 (1) :97-101.
[9]谢爱娣, 刘锦群, 陈晓梨.姜黄素治疗黄褐斑的疗效观察及其对黑素的影响[J].黑龙江医学, 2015, 39 (10) :1163-1164.
[10]	[10]VACHIRAMON V, PANMANEE W, TECHAPICHETVANICH T, et al.Comparison of Q-switched Nd:YAG laser and fractional carbon dioxide laser for the treatment of solar lentigines in Asians[J].Lasers Surg Med, 2016, 48 (4) :354-359.
[11]	[11]NOH T K, CHUNG B Y, YEO U C, et al.Q-switched660-nm versus 532-nm Nd:YAG laser for the treatment for facial lentigines in asian patients:A prospective, randomized, double-blinded, split-Face comparison pilot study[J].Dermatol Surg, 2015, 41 (12) :1389-1395.
[12]李娟, 颜敏, 张媛, 等.黄褐斑病因、发病机制及治疗进展[J].中国麻风皮肤病杂志, 2016, 32 (2) :123-126.
[13]张国栋, 黄恺飞, 黄亦琦.清斑胶囊对小鼠B16黑素细胞增值、酪氨酸酶活性及黑色素含量影响的研究[J].柳州医学, 2014, 27 (3) :125-12.
[14]马彦, 冯文莉, 杨静, 等.调Q开关翠绿宝石激光治疗282例色素性皮肤病临床分析[J].中国药物与临床, 2013, 13 (3) :301-304.
[15]刘丽琴, 杨晓红, 王金燕, 等.祛斑汤治疗气滞血瘀型黄褐斑疗效及对外周血中血管内皮生长因子的影响[J].中国中西医结合皮肤性病学杂志, 2015, 14 (6) :374-376.
[16]车启蕾, 付萌, 李承新.黄褐斑病因及发病机制的研究进展[J].国际皮肤性病学杂志, 2016, 42 (2) :82-83.
[17]黎颖诗, 杨海波, 黄艳, 等.强脉冲光联合Q开关Nd:YAG激光治疗雀斑的疗效观察[J].岭南皮肤性病科杂志, 2009, 16 (5) :299-301.

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