奥沙利铂针联合替吉奥胶囊治疗对晚期胃癌患者CEA、CA199、TAM水平及生活质量的影响
The Effect of Oxaliplatin Injection Combined with S-1 on Levels of CEA, CA199, TAM and the Quality of Life of Patients with Advanced Gastric Cancer
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摘要: 目的 探讨奥沙利铂针联合替吉奥胶囊治疗对晚期胃癌患者CEA、CA199、TAM水平及生活质量的影响.方法 回顾性选取广安医院2013年1月至2016年6月期间收治的70例晚期胃癌患者的临床资料, 根据化疗方案不同分为研究组 (n=35, 奥沙利铂针联合替吉奥胶囊) 和对照组 (n=35, 替吉奥胶囊) .评估2组治疗的近期疗效, 于治疗前后检测血清标本中血清肿瘤标志物水平, 并进行毒性反应及生活质量评价.结果 研究组总有效率、疾病控制率为45.71%、88.57%显著高于对照组的22.86%、71.43% (P<0.05) .2组治疗前血清肿瘤标志物癌胚抗原 (CEA) 、癌抗原199 (CA199) 、肿瘤相关物质 (TAM) 水平比较无统计学意义 (P>0.05) , 治疗后血清CEA、CA199、CEA水平均显著下降, 与治疗前相比差异有统计学意义 (P<0.05) , 且治疗后研究组血清CEA、CA199、CEA水平下降幅度显著大于对照组 (P<0.05) .研究组治疗期间及治疗后除恶心呕吐严重程度明显高于对照组外 (P<0.05) , 中性粒细胞减少、血小板减少、外周神经炎、肝或肾功能损害发生情况及严重程度与对照组相比无统计学意义 (P>0.05) .治疗后研究组KPS评分提高率显著高于对照组 (60.00%VS 31.42%) , 整体生活质量改善效果明显优于对照组 (P<0.05) .结论 奥沙利铂针联合替吉奥胶囊治疗晚期胃癌能有效抑制肿瘤细胞生长转移, 缓解病情, 提高临床治疗疗效, 且安全性高, 对改善患者生活质量有重要意义.Abstract: Objective To investigate the effect of oxaliplatin injection combined with S-1 on levels of carcinoembryonic antigen (CEA) , cancer antigen 199 (CA199) and tumor associated materials (TAM) and the quality of life of patients with advanced gastric cancer. Methods The clinical data of 70 patients with advanced gastric cancer treated in our hospital from January 2013 to June 2016 were retrospectively analyzed. According to different chemotherapy regimens, the patients were divided into the study group (n = 35, treated with oxaliplatin injection combined with S-1) and the control group (n = 35, treated with S-1) . The short-term curative effect in the two groups was evaluated, and levels of serum tumor markers were detected before and after the treatment.The toxicity and quality of life were evaluated. Results The total effective rate of treatment and disease control rate in the study group were significantly higher than those in the control group (45.71% and 88.57% vs 2.86% vs71.43%) (P < 0.05) . There were no significant differences in levels of serum CEA, CA199 and TAM between the two groups before the treatment (P > 0.05) . After the treatment, levels of serum CEA, CA199 and CEA were significantly decreased (P < 0.05) , and the decrease was significantly greater in the study group than in the control group (P < 0.05) . During and after the treatment, nausea and vomiting was more severe in the study group than in the control group (P < 0.05) , while the incidence rates of neutropenia, thrombocytopenia, peripheral neuritis and liver or kidney function damage showed no statistically significant difference (P > 0.05) . After the treatment, the improvement rate of KPS score in the study group was significantly higher than that in the control group (60% VS 31.42%) , and the overall improvement of the quality of life was significantly better than that in the control group (P < 0.05) . Conclusion Oxaliplatin injection combined with S-1 can effectively inhibit the growth and metastasis of tumor cells, remit the condition and improve the clinical efficacy with high safety in patients with advanced gastric cancer. It also can improve the quality of life of patients.
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Key words:
- Oxaliplatin injection /
- S-1 /
- Advanced /
- Gastric cancer /
- CEA /
- CA199 /
- TAM /
- Quality of life
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