Abstract: Objective To study the influence of tarsal gland massage on postoperative curative effect of femtosecond laser combined with excimer laser keratomileusis. Methods A prospective study was conducted on patients who underwent the same surgical approach by the same surgeon. 78 eligible patients were randomly divided into two groups: 39 patients in experimental group, equal to 78 eyes, were given tarsal gland massage before the operation; and the other 39 patients in control group, equal to 78 eyes, were not given tarsal gland massage before the operation. The presence condition of postoperative interlayer eyelid fat of the two groups of patients was investigated. After that, the patients were divided into two groups according to above eyelid fat condition: with eyelid fat group and without eyelid fat group, and the visual acuity recovery status were compared between the two groups.Results In the control group after the operation, 3 patients could not be contacted in the follow-up study, but a total of 36 patients, equal to 72 eyes were observed by slit lamp, and there were totally 10 eyes with interlayer eyelid fat, accounting for 13.89 %;Whereas, 2 patients could not be contacted in the experimental group, but a total of 37 patients, equal to 74 eyes were observed, and there were only 2 eyes with interlayer eyelid fat, accounting for 2.7%. The P value of comparison between these two groups was less than 0.01, which had statistical differences. There was significant difference between the two groups (P <0.05) in the recovery of visual acuity within one month after the operation. Conclusion Tarsal gland massage can effectively reduce the residual of interlayer eyelid fat after the operation of femtosecond laser combined with excimer laser keratomileusis, thereby it can avoid the delay of vision recovery and effectively improve the postoperative curative effect.