趋化素与阻塞性睡眠呼吸暂停低通气综合征患者咽部脂肪沉积的相关性

吴海莺; 曹守明; 施斌; 白忠; 李永霞

趋化素与阻塞性睡眠呼吸暂停低通气综合征患者咽部脂肪沉积的相关性

1. 昆明医科大学第二附属医院耳鼻咽喉科
2. 昆明医科大学第二附属医院呼吸科

基金项目:

基金：云南省卫计委内设机构研究项目 (2016NS290);

计量
- 文章访问数: 2106
- HTML全文浏览量: 715
- PDF下载量: 62
- 被引次数: 0
出版历程
- 收稿日期: 2017-09-01

Chemerin in Obstructive Sleep Apnea-hypopnea Patients' Pharyngeal Fat Deposition

Funds:

基金：云南省卫计委内设机构研究项目 (2016NS290);

摘要

摘要: 目的比较阻塞性睡眠呼吸暂停低通气综合征 (obstructive sleep apnea-hypopnea syndrome, OSAHS) 患者与非打鼾者的咽部脂肪趋化素水平, 分析趋化素对OSAHS患者咽部脂肪沉积的影响.方法以OSAHS住院的患者作为实验组, 非打鼾的慢性扁桃体炎患者作为对照组, 行多导睡眠监测并检测腭帆间隙脂肪组织趋化素水平, 并对比2组代谢综合征相关指标, 分析趋化素与上述因子之间的相关性.结果 OSAHS患者腭帆间隙脂肪组织中趋化素水平高于非打鼾组, 且与TG、HOMA-IR和尿酸水平等指标呈正相关.OSAHS患者的代谢综合征指标与对照组之间差异有统计学意义 (P<0.05) .结论 OSAHS患者咽部脂肪中趋化素水平高于对照组, 且与代谢综合征指标呈正相关.趋化素可能参与了OSAHS患者咽部脂肪沉积过程, 并与代谢综合征途径有关.
- 阻塞性睡眠呼吸暂停低通气综合征 /
- 趋化素 /
- 代谢综合征
Abstract: Objective To analyze the effect of chemerin on the pharyngeal fat deposition by comparing the level of chemerin of fat tissue in pharynx between the patients with OSAHS and non-snorer. Methods OSAHS patients finished PSG and non-snoring patients with tonsillitis as controlled group were examined to observe their chemerin level of space veli palatine. Comparisons of the chemerin level and the indexes of MS were made to analyze the relationship between chemerin and MS. Results The level of chemerin of space veli palatine in OSAHS patients was higher than that of the control groups. And the level of chemerin within the OSAHS patients also had positive correlation with TG、HOMA-IR and uric acid. We also found that the TG, HDL-C, FINS, HOMA-IR and the uric acid had statistical differences (P <0.05) between the two groups. Conclusion The level of chemerin of OSAHS group is exceed the control group and positively related with indexes of MS. Chemerin may take part in the development of fat deposition in pharynx of OSAHS patients, which may be through MS pathway.
- Obstructive sleep apnea-hypopnea syndrome /
- Chemerin /
- Metabolic Syndrome

HTML全文

参考文献(14)

[1]施斌, 吴海莺, 白忠.趋化素与阻塞性睡眠呼吸暂停低通气综合征相关性的研究进展[J].海南医学, 2017, 28 (6) :951-954.
[2]中华医学会耳鼻咽喉头颈外科学分会咽喉学组.阻塞性睡眠呼吸暂停低通气综合征诊断和外科治疗指南[J].中华耳鼻咽喉头颈外科杂志, 2009, 44 (2) :95-96.
[3]	[3]OUCHI N, PARKER J L, LUGUS J J, et al.Adipokines in inflammation and metabolic disease[J].Nat Rev Immunol, 2011, 11 (2) :85-97.
[4]	[4]POULOS S P, HAUSMAN D B, HAUSMAN G J.The development and endocrine functions of adipose tissue[J].Mol Cell Endocrinol, 2010, 323 (1) :20-34.
[5]	[5]NAGPAL S, PATEL S, JACOBE H, et al.Tazarotene-induced gene 2 (TIG2) , a novel retinoid-responsive gene in skin[J].J Invest Dermatol, 1997, 109 (1) :91-95.
[6]	[6] BOZAOGLU K, BOLTON K, MCMILLAN J, et al.Chemerin is a novel adipokine associated with obesity and metabolic syndrome[J].Endocrinology, 2007, 148 (10) :4687-4694.
[7]	[7]ISSA M E, MURUGANANDAN S, ERNST M C, et al.Chemokine-like receptor 1 regulates skeletal muscle cell myogenesis[J].Am J Physiol Cell Physiol, 2012, 302 (11) :C1621-1631.
[8]	[8]TAKAHASHI M, OKIMURA Y, IGUCHI G, et al.Chemerin regulates beta-cell function in mice[J].Sci Rep, 2011, 1 (11) :123.
[9]	[9]GORALSKI K B, MCCARTHY T C, HANNIMAN E A, et al.Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism[J].J Biol Chem, 2007, 282 (38) :28175-2888.
[10]	[10]ERNST M C, SINAL C J.Chemerin at the crossroads of inflammation and obesity[J].Trends Endocrinol Metab, 2010, 21 (11) :660-667.
[11]	[11]SELL H, LAURENCIKIENE J, TAUBE A, et al.Chemerin is a novel adipocyte-derived factor inducing insulin resistance in primary human skeletal muscle cells[J].Diabetes, 2009, 58 (12) :2731-2740.
[12]	[12]GU P, JIANG W, LU B, et al.chemerin is associated with inflammatory markers and metabolic syndrome phenotypes in hypertension patients[J].Clin Exp Hypertens, 2014, 36 (5) :326-332.
[13]	[13]BOZAOGLU K, BOLTON K, MCMILLAN J, et al.Chemerin is a novel adipokine associated with obesity and metabolic syndrome[J].Endocrinology, 2007, 148 (10) :4687-4694.
[14]	[14]BADRAN M, AYAS N, LAHER I.Insights into obstructive sleep apnea research[J].Sleep Med, 2014, 15 (5) :485-495.

相关文章(20)

[1]	田波, 金永梅, 李海雯, 李重熙, 张伟, 关玮, 陈海云, 薛琪, 杨惠榕, 刘俊. 艾滋病抗病毒治疗患者代谢综合征发生现况及影响因素, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20241121
[2]	曹渊卿, 自翔宇, 朱燕昆, 袁宝红. 减重术后早期血尿酸波动的相关性, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220924
[3]	唐嘉黛, 谢琳, 宋红莉, 陈娇娇. 代谢综合征与胃癌发生发展的相关性研究, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20211130
[4]	娄凡, 张铁松, 马静, 林垦, 赵丽萍. 慢性间歇性缺氧对阻塞性睡眠呼吸暂停低通气综合征儿童听功能的影响, 昆明医科大学学报.
[5]	乐小婧, 陈婕, 张帆, 李会芳. 代谢综合征与2型糖尿病的相关研究进展, 昆明医科大学学报.
[6]	李孔龙, 陈晶, 赵玲, 舒筠然, 柯亭羽. 阻塞性睡眠呼吸暂停低通气综合征与亚临床甲减的相关性, 昆明医科大学学报.
[7]	钮燕, 张越, 白忠, 杨晓红, 吴海莺, 曹守明, 马燕, 吕操. 256排螺旋CT在阻塞性睡眠呼吸暂停低通气综合征疾病诊断中的应用, 昆明医科大学学报.
[8]	饶宇, 雷雯, 李月秋, 李秘, 冯见琼, 王安敏, 王颖. IL-17在肺栓塞合并阻塞性睡眠呼吸暂停低通气综合征患者体内表达情况及其临床意义, 昆明医科大学学报.
[9]	张永康, 杨燕, 李国晖. 128层螺旋CT评价阻塞性睡眠呼吸暂停综合征的应用价值, 昆明医科大学学报.
[10]	邓小明. 改良悬雍垂腭咽成形术治疗阻塞性睡眠呼吸暂停低通气综合征274例, 昆明医科大学学报.
[11]	柯亭羽. 阻塞性睡眠呼吸暂停低通气综合征患者骨密度改变, 昆明医科大学学报.
[12]	范敏娟. 瘦素、胰岛素抵抗与阻塞性睡眠呼吸暂停低通气综合征关系的研究, 昆明医科大学学报.
[13]	张忍发. 不同运动方案对代谢综合征干预的效果比较, 昆明医科大学学报.
[14]	丘红梅. 代谢综合征患者胰岛素抵抗与血浆醛固酮相关性研究, 昆明医科大学学报.
[15]	欧阳慧蓉. 某高校教职工健康体检结果分析, 昆明医科大学学报.
[16]	严小宏. CPAP对2型糖尿病合并阻塞性睡眠呼吸暂停综合征治疗观察, 昆明医科大学学报.
[17]	王慧明. 阻塞性睡眠呼吸暂停综合征322例手术麻醉处理分析, 昆明医科大学学报.
[18]	何琴. 阻塞性睡眠呼吸暂停低通气综合征患者的下颌骨和颞下颌关节三维有限元模型的构建, 昆明医科大学学报.
[19]	. 持续气道正压通气治疗对OSAHS患者胰岛素抵抗的影响, 昆明医科大学学报.
[20]	. 代谢综合征与卒中后抑郁的关系, 昆明医科大学学报.