换血对高胆红素血症患儿肾功能、炎症因子及血液内环境的影响

屈晶磊; 杨远征

换血对高胆红素血症患儿肾功能、炎症因子及血液内环境的影响

屈晶磊¹,
杨远征²

1. 河北省血液中心成分科
2. 海南医学院第一附属医院重症医学科

基金项目:

基金：海南省卫生计生行业科研基金资助项目 (14A210207);

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出版历程
- 收稿日期: 2017-09-21

Effects of Exchange Transfusion on Renal Function, Inflammatory Factors and Blood Internal Environment in Children with Hyperbilirubinemia

Qu Jing Lei ¹,
Yang Yuan Zheng ²

Funds:

基金：海南省卫生计生行业科研基金资助项目 (14A210207);

摘要

摘要: 目的研究换血治疗对高胆红素血症患儿肾功能、炎症因子及血液内环境的影响.方法选择2015年2月至2017年3月高胆红素血症新生儿作为研究对象, 采用随机数表法分为2组, 联合组新生儿接受换血治疗联合蓝光照射、对照组新生人接受蓝光照射治疗.治疗后24 h, 测定血清中胆红素含量、肾功能指标、炎症反应指标及氧化应激反应指标.结果治疗后24 h, 联合组新生儿血清中TBIL、BUN、Cr、β2-MG、CysC、TRF、CRP、IL-6、TNF-α、MDA、AOPP的含量显著低于对照组, SOD、CAT、GSH-Px的含量显著高于对照组.结论换血治疗能够改善高胆红素血症患儿的肾功能、抑制炎症及氧化应激反应.
- 高胆红素血症 /
- 换血治疗 /
- 肾功能 /
- 炎症反应 /
- 氧化应激反应
Abstract: Objective To study the effects of exchange transfusion on renal function, inflammatory factors and blood internal environment in children with hyperbilirubinemia. Methods Neonates with hyperbilirubinemia treated in neonatal intensive care unit of the hospital between February 2015 and March 2017 were selected as the research subjects and divided into two groups by random number table method. Combined group received exchange transfusion combined with blue ray irradiation, and control group received blue ray irradiation. The serum levels of bilirubin, renal function indexes, inflammatory response indexes and oxidative stress response indexes were measured 24 hours after the treatment. Results 24 hours after the treatment, serum TBIL, BUN, Cr, β2-MG, Cys C, TRF, CRP, IL-6, TNF-α, MDA and AOPP levels of combined group were greatly lower than those of control group whereas SOD, CAT and GSH-Px contents were greatly higher than those of control group. Conclusion Exchange transfusion can improve the renal function and inhibit the inflammatory and oxidative stress response in children with hyperbilirubinemia.
- Hyperbilirubinemia /
- Exchange transfusion /
- Renal function /
- Inflammatory response /
- Oxidative stress response

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参考文献(12)

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