IL-10与自身免疫病的研究进展

陈墨; 周泽平

IL-10与自身免疫病的研究进展

陈墨,
周泽平

昆明医科大学第二附属医院血液科

基金项目:

作者简介：陈墨 (1992~) , 男, 湖北黄石市人, 在读硕士研究生, 主要从事血液科临床工作.; 周泽平.E-mail:zhouzeping@outlook.com男, 43岁, 博士, 教授, 博士研究生导师.2007年毕业于中国协和医科大学.现为昆明医科大学第二附属医院血液科主任, 云南省中青年学术及技术带头人后备人才, 云南省高层次卫生技术人才学科带头人, 云南省省级临床重点专科负责人, 昆明医科大学创新团队负责人.中华医学会血液学分会止血与血栓学组委员、青年委员, 云南省血液学会副主任委员, 中国研究型医院学会生物治疗学专委会委员, 中国老年医学会血液学分会委员, 昆明医科大学第七届学术委员会委员等.主持国家自然科学基金3项, 省部级项目8项, 发表论文50篇, 其中SCI收录23篇.参编英文专著1部及中文专著5部.;

基金：国家自然科学基金资助项目 (81560029); 云南省中青年学术及技术带头人后备人才基金资助项目 (2013HB088);

计量
- 文章访问数: 3091
- HTML全文浏览量: 993
- PDF下载量: 318
- 被引次数: 0
出版历程
- 收稿日期: 2017-11-19

The Progress of IL-10 and Autoimmune Diseases

Chen Mo ,
Zhou Ze Ping

Funds:

基金：国家自然科学基金资助项目 (81560029); 云南省中青年学术及技术带头人后备人才基金资助项目 (2013HB088);

摘要

摘要: IL-10是一种被广泛表达的单链糖蛋白多效细胞因子, 既可以由适应性免疫细胞产生也可以由固有免疫细胞产生.IL-10的特异性受体是复合物, 由IL-10R1和IL-10R2两个亚单位构成, 主要通过JAK-STAT通路发挥生物学功能.IL-10作为一种关键的抗炎细胞因子参与机体免疫调节, 在多种自身免疫病中发挥重要作用.综合整理近几年的最新研究成果, 探讨IL-10与自身免疫病的关系.
- IL-10 /
- 免疫调节 /
- 自身免疫病
Abstract: Interleukin-10 (IL-10) , a single strand glycoprotein, is produced by both adaptive and innate immune cells. IL-10 specific receptor as a complex consists of two submits IL-10 R1 and IL-10 R2. IL-10 mainly plays biological functions via JAK-STAT signaling pathway. IL-10 is a crucial anti-inflammation cytokine taking part in immune regulation and having significant effect on autoimmune diseases. This paper reviews the relationships between IL-10 and autoimmune diseases according to research achievements in recent years.
- Interleukin-10 /
- Immune regulation /
- Autoimmune diseases

HTML全文

参考文献(23)

[1]	[1]RAMAKRISHNAN V, HUSAIN R A, AHMED S S.Genetic predisposition of IL-10 promoter polymorphisms with risk of multiple sclerosis:A meta-analysis[J].Journal of Neuroimmunology, 2017, 306 (3) :11-18.
[2]	[2]RAJASEKARAN A, SHIVAKUMAR V, KALMADY S V, et al.The impact of IL10 polymorphisms and s HLA-G levels on the risk of schizophrenia.[J].Asian Journal of Psychiatry, 2016, 23 (2) :39-43.
[3]	[3]PALMER V L, NGANGA V K, ROTHERMUND M E, et al.Cd1d regulates B cell development but not B cell accumulation and IL10 production in mice with pathologic CD5 (+) B cell expansion[J].Bmc Immunology, 2015, 16 (1) :66-67.
[4]	[4]BERTI F C B, PEREIRA A P L, TRUGILO K P, et al.IL-10, gene polymorphism c.-592C>A increases HPV infection susceptibility and influences IL-10 levels in HPV infected women[J].Infection Genetics&Evolution Journal of Molecular Epidemiology&Evolutionary Genetics in Infectious Diseases, 2017, 53 (14) :128-134.
[5]	[5]SHOUVAL D S, BISWAS A, KANG Y H, et al.Interleukin 1βMediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency[J].Gastroenterology, 2016, 151 (6) :1100-1101.
[6]	[6]KHARE V, PAUL G, MOVADAT O, et al.IL10R2 Overexpression Promotes IL22/STAT3 Signaling in Colorectal Carcinogenesis[J].Cancer Immunology Research, 2015, 3 (11) :2326-6066.
[7]	[7]KAPELSKI P, SKIBINSKA M, MACIUKIEWICZ M, et al.Family-based association study of interleukin 10 (IL10) and interleukin 10 receptor alpha (IL10RA) functional polymorphisms in schizophrenia in Polish population[J].Journal of Neuroimmunology, 2016, 297 (11) :92-97.
[8]	[8]DENNIS K L, SAADALLA A, BLATNER N R, et al.T-cell expression of IL10 is essential for tumor immune surveillance in the small intestine[J].Cancer Immunology Research, 2015, 3 (7) :806-807.
[9]	[9]OSADA Y, FUJIYAMA T, KAMIMURA N, et al.Dual genetic absence of STAT6 and IL-10 does not abrogate anti-hyperglycemic effects of Schistosoma mansoni in streptozotocin-treated diabetic mice.[J].Experimental Parasitology, 2017, 177 (5) :1-12.
[10]	[10]LIU X, ZHANG S, LI X, et al.Vaccination with a co-expression DNA plasmid containing GAD65 fragment gene and IL-10 gene induces regulatory CD4 (+) T cells that prevent experimental autoimmune diabetes[J].Diabetes/metabolism Research&Reviews, 2016, 32 (6) :522-533.
[11]	[11]LI Y Y, PEARSON J A, CHEN C, et al.Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) modulates T1DM susceptibility by gut microbiota[J].Journal of Autoimmunity, 2017, 54 (8) :10-14.
[12]	[12]HEINEMANN K, WILDE B, HOERNING A, et al.Decreased IL-10 (+) regulatory B cells (Bregs) in lupus nephritis patients[J].Scandinavian Journal of Rheumatology, 2016, 33 (4) :1-2.
[13]	[13]YANG X, SUN B, WANG H, et al.Increased serum IL-10in lupus patients promotes apoptosis of T cell subsets via the caspase 8 pathway initiated by Fas signaling[J].Journal of Biomedical Research, 2015, 29 (3) :232-240.
[14]	[14]VADASZ Z, PERI R, EIZA N, et al.The Expansion of CD25high IL-10high Fox P3high B Regulatory Cells Is in Association with SLE Disease Activity[J].Journal of immunology Research, 2015, 2015 (4) :1-6.
[15]	[15]LI X, ZHONG H, BAO W, et al.Defective regulatory B-cell compartment in patients with immune thrombocytopenia[J].Blood, 2012, 120 (16) :3318-3325.
[16]	[16]MOKHTAR G M, ELBEBLAWY N M, Adly A A, et al.Cytokine gene polymorphism[tumor necrosis factor-alpha (-308) , IL-10 (-1082) , IL-6 (-174) , IL-17F, 1Ra VNTR]in pediatric patients with primary immune thrombocytopenia and response to different treatment modalities.[J].Blood Coagul Fibrinolysis, 2016, 27 (2) :34-38.
[17]	[17]HUA F, YING L, XIN Z, et al.The expression profile of toll-like receptor signaling molecules in CD19+, B cells from patients with primary immune thrombocytopenia[J].Immunology Letters, 2016, 176 (11) :28-35.
[18]	[18]TAWFIK T Z, GAD A H, MEHANEY D A, et al.Interleukins 17 and 10 in a sample of Egyptian relapsing remitting multiple sclerosis patients[J].Journal of the Neurological Sciences, 2016, 369 (22) :36-38.
[19]	[19]RONG Z, ZENG H, YUN Z, et al.CD226 ligation protects against EAE by promoting IL-10 expression via regulation of CD4+T cell differentiation[J].Oncotarget, 2016, 7 (15) :19251-19264.
[20]	[20]RAMAKRISHNAN V, HUSAIN R A, AHMED S S.Genetic predisposition of IL-10 promoter polymorphisms with risk of multiple sclerosis:A meta-analysis[J].Journal of Neuroimmunology, 2017, 306 (12) :11-18.
[21]	[21]ISHIGURO K, WATANABE O, NAKAMURA M, et al.S100G expression and function in fibroblasts on colitis induction[J].International Immunopharmacology, 2016, 39 (6) :92-96.
[22]	[22]ZHOU L, CHENG L, HE Y, et al.Association of gene polymorphisms of FV, FII, MTHFR, SERPINE1, CTLA4, IL10, and TNFalpha with pre-eclampsia in Chinese women[J].Inflammation Research, 2016, 65 (9) :1-8.
[23]	[23]GUO P, LI G, SUN X, et al.Influence of IL10 Gene polymorphisms on the sustained virologic response of patients with chronic hepatitis C to PEG-interferon/ribavirin therapy[J].Infection Genetics&Evolution Journal of Molecular Epidemiology&Evolutionary Genetics in Infectious Diseases, 2016, 45 (6) :48-55.

相关文章(20)

[1]	世淑兰, 邱丽娟, 奎莉越, 苏敏, 周百灵, 李荣杰, 孙建明. IL-6、IL-10、hs-CRP及PCT在儿童急性淋巴细胞白血病合并感染中的诊断价值, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230115
[2]	石苒羲, 杨涛, 程庆, 赵梁辰, 郭嘉晖, 王利梅. 基于网络药理学与分子对接探讨铁皮石斛抗炎性衰老的作用, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20231101
[3]	梁国柱, 阮诗媚, 何艳梅, 杨海龙. 抗菌肽作为免疫调节剂治疗细菌感染的潜力, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20231013
[4]	戴微微, 冯伟伟, 李德富, 林钐, 秦苇. 风湿免疫病住院患者的抑郁与自杀风险分析, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220302
[5]	杨洋, 杨雪松, 叶建州, 李泓莹, 陈思璇. 健脾养血祛风法调节AD的免疫屏障的研究进展, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210220
[6]	全宇航, 王忠慧, 汪亚宏. 麻醉药物对肺癌患者IMA、TNF-α、IL-10的影响, 昆明医科大学学报.
[7]	莽源祎, 李立, 冉江华, 升宁, 刘静, 刘剑, 高杨, 李来邦. 特利加压素联合FK-409通过减少IL-10和TNF-α释放保护移植肝的机制, 昆明医科大学学报.
[8]	程敏, 施开德, 刘星. 血清淀粉酶、血清胰蛋白酶原-2、PAF以及IL-10联合检测在诊断ERCP术后胰腺炎中的应用, 昆明医科大学学报.
[9]	徐嵘. 超声检测气管旁淋巴结对自身免疫甲状腺炎的诊断价值, 昆明医科大学学报.
[10]	李莹. 云南汉族人群IL-10基因启动子多态性与HCV慢性感染的相关性研究, 昆明医科大学学报.
[11]	姚娜. IL-6，IL-10在实验性肺部炎症中的研究进展, 昆明医科大学学报.
[12]	李晓勇. Th17/Treg平衡失调及其相关因子在乳腺癌浸润转移的相关性研究, 昆明医科大学学报.
[13]	赵敏. 老年直肠癌患者轻度低温下IL-2、IL-10变化与术后早期认知功能相关性的研究, 昆明医科大学学报.
[14]	周义忠. 血IL-10、IL-5、IL-2、IFN-γ水平在反复腹痛患儿及其家庭成员中的比较, 昆明医科大学学报.
[15]	王峰. 昆明医科大学微生物学与免疫学教研室，云南昆明　650500, 昆明医科大学学报.
[16]	吴华美. 自身免疫性肝病92例临床和病理分析, 昆明医科大学学报.
[17]	. 自身免疫性肝病92例临床和病理分析, 昆明医科大学学报.
[18]	. 严重创伤大鼠TNF-α、p-EP及IL-1O的动态变化, 昆明医科大学学报.
[19]	. 严重创伤大鼠TNF-α、β-EP及IL-10的动态变化, 昆明医科大学学报.
[20]	张才军. 结核清注射剂对小鼠免疫调节的实验研究, 昆明医科大学学报.