秋水仙碱、苯溴马隆胶囊联合治疗痛风性关节炎非急性发作期
A Clinical Study of Combined Therapy of Colchicine and Benzbromarone Capsules in the Treatment of Gouty Arthritis at Non-Acute Episode Stage
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摘要: 目的 探析秋水仙碱、苯溴马隆胶囊联合治疗痛风性关节炎非急性发作期的临床价值.方法 收集2015年12月至2017年2月核工业四一六医院收治的60例痛风性关节炎非急性发作期患者, 随机分为联合组和对照组, 各30例.对照组给予苯溴马隆胶囊, 联合组给予秋水仙碱+苯溴马隆胶囊, 对比2组患者治疗前后实验室指标[血尿酸、血沉 (ESR) 、C反应蛋白 (CRP) 、丙氨酸转氨酶 (ALT) 、肾小球滤过率 (GFR) ]、疼痛症状及生活质量的变化情况, 统计急性痛风性关节炎的发作次数及药物不良反应的发生率.结果 治疗前2组患者实验室相关指标、临床症状及生活质量对比差异无统计学意义 (P>0.05) ;疗程结束后, 2组患者ALT、GFR水平未见明显波动, 但血尿酸、ESR、CRP、疼痛症状及生活质量均得到改善, 联合组改善程度较对照组优;同时, 治疗期间联合组急性痛风性关节炎的发作次数亦较对照组少, 上述指标组间对比差异具有统计学意义 (P<0.05) , 联合组不良反应总发生率为30.00%, 与对照组的26.67%行组间比较差异无统计学意义 (χ2=0.180, P=0.857) .结论 秋水仙碱、苯溴马隆胶囊联合治疗痛风性关节炎非急性发作期安全性与单用苯溴马隆胶囊无异, 且疗效优于单一使用苯溴马隆.
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关键词:
- 秋水仙碱 /
- 苯溴马隆胶囊 /
- 痛风性关节炎非急性发作期
Abstract: Objective To explore and analyze the clinical values of combined therapy of colchicine and benzbromalone capsules in the treatment of gouty arthritis of non-acute episode. Methods From December 2015 to February 2017, 60 patients with gouty arthritis who were not in acute attack were randomly divided into the combined group and the control group, with 30 cases in each group. The control group was given benzbromarone capsules and the combined group was given colchicine combined with benzbromarone capsules. The changes of laboratory indexes [blood uric acid, erythrocyte sedimentation rate (ESR) , C reactive protein (CRP) , alanine aminotransferase (ALT) , glomerular filtration rate (GFR) ], and clinical symptoms (pain, lesion joint limitation, fever, redness and tenderness) were measured and compared in the two groups before and after the treatment. The daily living ability scale (SF-36) was used to evaluate the quality of daily life before and after the treatment, and the incidence rate of drug adverse reactions during the treatment was also counted. Results No significant differences were found in the laboratory related indexes, clinical symptoms and quality of life before the treatment between the two groups (P>0.05) . After the treatment, the levels of ALT and GFR were not significantly fluctuated in the two groups, but the levels of blood uric acid, ESR, CRP, pain symptoms and quality of life were improved, and the increasing degree in the combined group was more significant than that of the control group. and the number of episodes of acute gouty arthritis in the combined group was also lower than that in the control group, and the difference between the above indexes was statistically significant (P<0.05) . The total incidence rate of adverse reactions was 30% in the combined group, which was not significantly different from that in the control group with 26.67% (χ2 = 0.180, P = 0.857) . Conclusions The use of colchicine combined with benzbromalone capsules is as the safe as the single use of benzbromalone capsules and the effect of the former one is better than that of the latter one in the treatment of gouty arthritis at non-acute episode stage. -
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