黄花白及化学成分研究(英文)
Chemical Constituents from Bletilla Ochracea
-
摘要: 目的 研究黄花白及化学成分.方法 黄花白及全草溶剂提取、硅胶柱层析和Sephadex LH-20柱层析进行分离纯化, 波谱分析 (核磁共振氢谱、碳谱、和质谱) 确定结构.结果 从该药用植物分离并鉴定了9个化合物, 分别为:lusianthridin (1) , 1, 2, 7-trihydroxy-4-methoxy-9, 10-dihydroxyphenanthrene (2) , nudol (3) , coelonin (4) , batatasin Ⅲ (5) , 3, 7-dihydroxy-2, 4-dimethoxyphenanthrene (6) , daucosterol (7) , β-sitosterol (8) , stigmasterol (9) .结论 化合物2, 3, 5为首次从本植物中分离得到.Abstract: Objective To study the chemical constituents from Bletilla ochracea. Methods The compounds were extracted by 95% alcohol and isolated by column chromatography on silica gel and Sephadex LH-20. Their structures were identified by spectroscopic analysis (~1 H NMR and 13 CNMR) .Results Nine compouds were obtained and identified as lusianthridin (1) , 1, 2, 7-trihydroxy-4-methoxy-9, 10-dihydroxyphenanthrene (2) , nudol (3) , coelonin (4) , batatasin Ⅲ (5) , 3, 7-dihydroxy-2, 4-dimethoxyphenanthrene (6) , daucosterol (7) , β-sitosterol (8) , stigmasterol (9) .Conclus ion Compounds 2, 3, 5 were isolated from this plant for the first time.
-
Key words:
- Bletilla ochracea /
- Bizenzyls /
- Phenanthrenes /
- Dihydrophenanthrenes
-
[1] [1]JIANGSU NEW MEDICINAL COLLEGE.The dictionary of Chinese herbal medicines[M].Volume 2.Shanghai:Shanghai Science and Technology Publisher, 1977:2041-2044. [2] [2] YANG X Z, TANG C P, ZHAO P, et al.Antimicrobial constituents from the tubers of Bletilla ochracea[J].Planta Med, 2012, 78 (4) :606-610. [3] [3]LIU M F, DING Y, ZHANG D M.Phenanthrene constitunets from rhizome of Arundina graminifolia[J].China JChin Mater Med, 2005, 30 (5) :353-356. [4] [4]LIN Y L, CHEN W P, CACABALANG A D.Dihydrophenanthrenes from Bletilla formosana[J].Chem Pharm Bull, 2005, 53 (9) :1111-1113. [5] [5]LEONG Y W, KANG C C, HARRISON L J, et al.Phenanthrenes, dihydrophenanthrenes and bibenzyls from the orchid Bulbophyllum vaginatum[J].Phytochemistry, 1997, 44 (1) :157-165. [6] [6]ZHU H, SONG Q S.Chemical components of Arundina graminifolia[J].Nat Product Res Dev, 2008, 20 (1) :5-7. [7] [7]LIU M F, HAN Y, XING D M, et al.A new stilbenoid from Arundina graminifolia[J].J Asian Nat Product Res, 2004, 6 (3) :229-232. [8] [8]MAJUMDER P L, BANERJEE S.Two Stilbenoids from the Orchid Eria flava[J].Phytochemistry, 1990, 29 (9) :3052-3055. [9] [9]CHEN Y P, LI Y P, ZHANG Z, et al.Chemical Constituents from the Flowers of Dendrobium thyrsiflorum[J].Journal of Kunming Medical University, 2016, 37 (1) :5-7. [10] [10]CHENG Y P, WANG Y J, LI Y P, et al.Research of chemical constituents from Dendrobium chrysotoxum[J].Asia-Pacific Traditional Medicine, 2015, 11 (3) :14-15. [11] [11]YAMAKI M, BAI L, KATO T, et al.Biphenanthrene ethers from Bletilla striata[J].Phytochemistry, 1992, 31 (11) :3985-3987. [12] [12]FENG J Q, ZHANG R J, ZHAO W M.Novel bibenzyl derivatives from the tubers of Bletilla striata[J].Helv Chim Acta, 2008, 91 (3) :520-525. [13] [13]YAMAKI M, BAI L, INOUE K, et al.Biphenanthrenes from Bletilla striata[J].Phytochemistry, 1989, 28 (12) :3503-3505. [14] [14]YANG X, TANG C, ZHAO P, et al.Antimicrobial constituents from the tubers of Bletilla ochracea[J].Planta Med, 2012, 78 (6) :606-610. [15] [15]DONG L, XIA S, LUO Y, et al.Targeting delivery oligonucleotide into macrophages by cationic polysaccharide from Bletilla striata successfully inhibited the expression of TNF-α[J].J Controlled Release, 2009, 134 (3) :214-220. [16] [16]YAMAKI M, BAI L, INOUE K, et al.Benzylphenanthrenes from Bletilla striata[J].Phytochemistry, 1990, 29 (7) :2285-2287. [17] [17]BAI L, KATO T, INOUE K, et al.Stilbenoids from Bletilla striata[J].Phytochemistry, 1993, 33 (6) :1481-1483. [18] [18]BAI L, KATO T, INOUE K, et al.Blestrianol A, B and C, biphenanthrenes from Bletilla striata[J].Phytochemistry, 1991, 30 (8) :2733-2735. [19] [19]YAMAKI M, BAI L, KATO T, et al.Blespirol, a phenanthrene with a spirolactone ring from Bletilla striata[J].Phytochemistry, 1993, 33 (6) :1497-1498. [20] [20]YAMAKI M, HONDA C, KATO T, et al.The steroids and triterpenoids from Bletilla striata[J].Nat Med, 1997, 51 (5) :493. [21] [21]HAO YAN-XIA, DENG YAN-RU, ZHANG XI-AO-JING, et al.Advances in chemical constituents and pharmacology of genus Bletilla[J].Nat Prod Res Dev, 2013, 25 (5) :1137-1145. [22] [22]TANG YI-FEI, RUAN CHUAN-FEN, YING CHEN, et al.Research progress on chemical constituents and medical functions in plants of Bletilla Rchb[J].Chinese Traditional and Herbal Drugs, 2014, 45 (19) :2864-2872.
点击查看大图
计量
- 文章访问数: 2900
- HTML全文浏览量: 1138
- PDF下载量: 75
- 被引次数: 0