甲状腺功能与胃肠运动及胃动素水平的关系

高聪; 刘兵; 王凯

甲状腺功能与胃肠运动及胃动素水平的关系

四川省人民医院急诊科

基金项目:

基金：四川省卫生厅科研基金资助项目 (110243);

计量
- 文章访问数: 2835
- HTML全文浏览量: 878
- PDF下载量: 78
- 被引次数: 0
出版历程
- 收稿日期: 2017-11-10

Study on the Relationship between Thyroid Function and Gastrointestinal Motility and Motilinlevels

Funds:

基金：四川省卫生厅科研基金资助项目 (110243);

摘要

摘要: 目的探讨甲状腺功能与胃肠运动及胃动素水平的关系, 为临床应用提供依据.方法选取2013年1月至2016年1月间四川省人民医院收治的60例甲状腺功能异常患者, 其中30例甲状腺功能亢进患者作为甲亢组、30例甲状腺功能减退患者作为甲减组, 30例健康体检者作为对照组;采用放射免疫法检测血清中胃动素水平, 同位素单光子辐射计算机断层显像技术检测患者胃液体半排时间、食管通过时间.结果甲减组受试者食管通过时间明显高于甲亢组及对照组, 差异有统计学意义 (P<0.05) , 甲减组显著高于对照组 (P<0.04) ;甲亢组患者血清中胃动素水平显著高于对照组 (P<0.05) , 甲减组患者血清中胃动素水平显著低于对照组 (P<0.05) ;甲亢与胃动素水平呈正相关关系 (P<0.05) , 与食管通过时间及胃排空时间呈负相关关系 (P<0.05) .甲减与胃动素水平呈负相关关系 (P<0.05) , 与食管通过时间及胃排空时间呈正相关关系 (P<0.05) .结论甲状腺功能亢进可导致胃肠道功能及胃动素水平升高, 甲状腺功能减退可导致胃肠道功能及胃动素水平下降.
- 甲状腺功能 /
- 胃肠运动 /
- 胃动素
Abstract: Objective To analysis the relationship between thyroid function with gastrointestinal motility and plasma motilin levels, and to provide the basis for clinical application.Me thods We selected 30 cases of patients with hyperthyroidism, 30 cases of hyperthyroidism group and hypothyroidism as hypothyroidism group, and 30 healthy volunteers as control group who were treated in our hospital from January 2013 to January 2016 in;The radioimmunoassay was used to test serum motilin levels, isotope single photon emission computed tomography was used to detected the gastric liquid technology half time, esophageal transit time.Re s ults The esophagus passage time of the subjects in the hypothyroidism group was significantly higher than that of the hyperthyroidism group and the control group, and the difference was statistically significant (P<0.05) ;The level of motilin in serum of hyperthyroidism group was significantly higher than that of control group (P<0.05) , and the level of motilin in serum of hypothyroidism group was significantly lower than that of control group (P<0.05) ;Hyperthyroidism was positively correlated with motilin level (r = 0.542, P<0.05) , and negatively correlated with the time of passage of the esophagus and gastric emptying time (r =-0.126 and r =-0.481, P<0.05) ;Hypothyroidism was negatively correlated with motilin level (r =-0.617, P<0.05) , and positively correlated with esophageal transit time and gastric emptying time (r = 0.627 and r = 0.416, P <0.05) .Conclus ions Hyperthyroidism can lead to the increase of gastrointestinal function and motilin level. Hypothyroidism can lead to the decrease of gastrointestinal function and motilin level.
- Thyroid function /
- Gastrointestinal motility /
- Motilin

HTML全文

参考文献(15)

[1]	[1]PEETERS T L.Gastrointestinal hormones and gut motility[J].Current Opinion in Endocrinology, Diabetes and Obesity, 2015, 22 (1) :9-13.
[2]	[2]HELLSTRM P M, TACK J, JOHNSON L V, et al.The pharmacodynamics, safety and pharmacokinetics of single doses of the motilin agonist, camicinal, in type 1 diabetes mellitus with slow gastric emptying[J].British journal of pharmacology, 2016, 173 (11) :1768-1777.
[3]	[3]DADU R, HU M I, CLEELAND C, et al.Efficacy of the natural clay, calcium aluminosilicate anti-diarrheal, in rducing medullary thyroid cancer related diarrhea and its efects on quality of life:A pilot study[J].Thyroid, 2015, 25 (10) :1085-1090.
[4]孙丹彬.2型糖尿病合并甲状腺功能异常的中医症候学研究[D].北京:北京中医药大学, 2014.
[5]	[5]KAZEMI M H, ESHRAGHIAN A, HAMIDPOUR L, et al.Changes in serum ghrelin level in relation to meal-time in patients with functional dyspepsia[J].United European gastroenterology journal, 2015, 3 (1) :11-16.
[6]	[6]CERANOWICZ P, WARZECHA Z, DEMBINSKI A.Peptidyl hormones of endocrine cells origin in the gut—their discovery and physiological relevance[J].Journal of Physiology and Pharmacology, 2015, 66 (1) :11-27.
[7]陈姗.甲状腺功能异常时血清生长素水平的变化[D].石家庄:河北医科大学, 2014.
[8]	[8]STASI C, MILANI S.Functions of ghrelin in brain, gut and liver[J].CNS&Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS&Neurological Disorders) , 2016, 15 (8) :956-963.
[9]	[9]BRENNER D M, SHAH M.Chronic vonstipation[J].Gastroenterology Clinics of North America, 2016, 45 (2) :205-216.
[10]	[10]BISSCHOPS R, DE RUYTER V, DEMOLIN G, et al.Lanreotide autogel in the treatment of idiopathic refractory diarrhea:Results of an exploratory, controlled, before and ater, open-label, multicenter, prospective clinical trial[J].Clinical Therapeutics, 2016, 38 (8) :1902-1911.
[11]李伟.甲状腺激素对慢性肾脏病合并亚临床甲减患者营养状况的研究[D].泰安:泰山医学院, 2014.
[12]	[12]PANDE R.functional dyspepsia-an updated review[J].Rwanda Medical Journal, 2015, 72 (3) :5-7.
[13]	[13]CORSETTI M, AKYUZ F, TACK J.Targeting tachykinin receptors for the treatment of functional gastrointestinal disorders with a focus on irritable bowel syndrome[J].Neurogastroenterology&Motility, 2015, 27 (10) :1354-1370.
[14]王红梅, 王谢桐.妊娠合并甲状腺功能亢进症的诊治[J].中国实用妇科与产科杂志, 2013, 29 (06) :415-419.
[15]	[15]ASTBURY S, MOSTYN A, SYMONDS M E, et al.Nutrient availability, the microbiome, and intestinal transport during pregnancy[J].Applied Physiology, Nutrition, and Metabolism, 2015, 40 (11) :1100-1106.

相关文章(20)

[1]	吴长勇, 王睿, 保苏丽, 李锐洁, 孙煌, 叶雨佳, 徐菲, 彭云珠. 运动康复对心肌梗死大鼠心脏纤维化及心功能的影响, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20231004
[2]	蔺小英, 谭艳, 杨磊. 双重任务训练对帕金森病患者运动功能的影响, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230110
[3]	秦榕, 苏纲, 张宇, 殷巍, 赵震. 右美托咪定联合甲磺酸多拉司琼对腹腔镜袖状胃切除术患者血浆胃动素及术后恶心呕吐的影响, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230215
[4]	徐璇, 陈茉弦, 刘光磊, 徐骁, 罗长良, 周娅. 痉挛型偏瘫患儿注意力与运动功能的相关性, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220319
[5]	贾万优, 刘红莉, 蒋薇薇, 李红敏, 张硕, 费继敏. 甲状腺术后甲状旁腺功能减退的风险因素, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220904
[6]	廖佳伟, 胡晓庆, 杨毅. 乳腺癌根治术患者放化疗前后甲状腺功能变化情况及其临床意义, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220229
[7]	李蕊, 张萍, 魏鲁刚, 房红梅, 王刘艳, 卢静怡, 陈曦, 杨菊. MHI对脑卒中患者膈肌运动和肺功能的临床疗效, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210616
[8]	刘幸, 李海雯, 黄红丽, 沈凌筠, 张乐, 刘向芳, 张文林, 王璐. 益生菌强化肠内营养支持对重症急性胰腺炎患者胃肠道功能和炎症因子的影响, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20211116
[9]	王汝姣, 张玲, 杨继英, 周强, 孙凤琴, 张玉林, 黄微. 不同程度认知障碍与甲状腺功能测定的相关性, 昆明医科大学学报.
[10]	黄莉, 史娅平. 体位和活动指导对妇科腹腔镜术后患者胃肠功能恢复的影响, 昆明医科大学学报.
[11]	韩文菊, 牛奔, 梁赟, 段晓燕, 苏恒, 薛元明. 甲状腺功能正常的2型糖尿病甲状腺激素与嘌呤代谢和体重的相关性, 昆明医科大学学报.
[12]	夏旭. 腹腔镜保胆取石术对胆囊结石患者胃肠道功能恢复的影响, 昆明医科大学学报.
[13]	蔺瑾. 甲状腺素片治疗妊娠合并亚临床甲状腺功能减退的研究, 昆明医科大学学报.
[14]	芮桥安. 孕早期甲状腺功能筛查对妊娠合并亚临床甲状腺功能减退的应用价值研究, 昆明医科大学学报.
[15]	李冰. 甲状腺功能减退性晕厥1例报道, 昆明医科大学学报.
[16]	任爱红. 活性炭胃肠灌洗治疗对有机磷中毒患者肝功能恢复的意义, 昆明医科大学学报.
[17]	陈卫文. 妊娠期甲状腺功能减退的临床研究, 昆明医科大学学报.
[18]	. 运动处方在脑卒中偏瘫患者上肢功能康复中的疗效观察, 昆明医科大学学报.
[19]	. IFNα引起甲状腺功能亢进治疗的初探, 昆明医科大学学报.
[20]	段艳萍. GAP-43对脊髓全横断损伤后的运动功能的影响, 昆明医科大学学报.