肿瘤组织内肿瘤浸润淋巴细胞和前列腺癌术后复发的关系

冉震; 朱云莎; 海冰; 张劲松

肿瘤组织内肿瘤浸润淋巴细胞和前列腺癌术后复发的关系

1. 昆明市第二人民医院泌尿外科
2. 昆明医科大学第二附属医院泌尿外科

基金项目:

基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2017FE468);

计量
- 文章访问数: 1908
- HTML全文浏览量: 671
- PDF下载量: 94
- 被引次数: 0
出版历程
- 收稿日期: 2017-11-19

Relationship between the Proportion of Tumor Infiltrating Lymphocytes in Tumor Mass and Postoperative Recurrence of Prostate Carcinoma

Funds:

基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2017FE468);

摘要

摘要:
目的探讨前列腺癌肿瘤浸润淋巴细胞 (TIL) 与前列腺癌患者术后复发的关系, 为临床上研究和预防前列腺癌术后复发提供理论及实验依据.方法采用流式细胞仪对81例前列腺癌根治术术后肿瘤组织内CD3+、CD8+、CD3+CD4+和CD3+CD8+TIL细胞进行测定分析, 回顾性比较前列腺癌术后<3 35="" a="">5 a无复发 (C组) 的患者肿瘤组织内CD3+CD8+TIL细胞比例, 对比分析各组前列腺癌术后复发与肿瘤组织内CD3+CD8+TIL细胞比例的关系.结果行前列腺癌根治术患者3 a内复发患者 (A组) 较35 a复发患者 (B组) 和5 a内无肿瘤复发患者 (C组) CD3+CD8+TIL细胞比例明显较低 (P<0.05) , 而C组患者CD3+CD8+TIL细胞比例较A、B 2组明显升高 (P<0.05) p="">0.05) .结论对于可手术切除前列腺癌患者, 其肿瘤内CD3+CD8+TIL细胞比例与前列腺癌术后复发有相关性, 其可能作为监测前列腺术后复发的一个生物学指标, 为临床预防或控制前列腺癌的术后复发转移提供新的思路.
- 前列腺癌 /
- 复发 /
- 肿瘤浸润淋巴细胞
Abstract:
Objective To investigate the relationship between proportion of Tumor infiltrating lymphocytes (TILs) in the prostate tumor mass and postoperative recurrence of prostate carcinoma in order to offer the theoretic as well as experimental basis for the prevention of postoperative recurrence in the prostate carcinoma.Methods The proportion of CD3+, CD8+, CD3+CD4+, CD3+CD8+ TILs cells of 81 PCa specimens underwent Radical prostatectomy were analyzed. The proportion of CD3+CD8+TILs in patients with recurrence of PCa within3 years after surgery (group A), within 35 years (group B) and without recurrence after 5 years (group C) was compared. Results The proportion of CD3+CD8+TILs was significantly lower in group A than that of in group B and C (P<0.05), meanwhile, the proportion of CD3+CD8+TILs were significantly higher in group C than that in group A and B (P<0.05), while="" the="" proportion="" of="" in="" three="" groups="" had="" no="" significant="" difference="" p="">0.05). Conclusion The proportion of CD3+CD8+TILs presented in the PCa specimen mass is relative to the postoperative recurrence of prostate cancer, which might be a biomarker for the surveillance of postoperative recurrence of PCa.
- Prostate cancer /
- Recurrence /
- Tumor infiltrating lymphocytes

HTML全文

参考文献(18)

[1]孙颖浩:前列腺癌诊治进展[J].上海医学, 2011, (7) :487-488.
[2]	[2]GILBERT R, MARTIN R M, EVANS D M, et al.Incorporating known genetic variants does not improve the accuracy of PSA testing to identify high risk prostate cancer on biopsy[J].PLo S One, 2015, 10 (10) :e0136735.
[3]	[3]CHAMIE K, WILLIAMS S B, HERSHMAN D L, et al.Population-based assessment of determining predictors for quality of prostate cancer surveillance[J].Cancer, 2015, 121 (23) :4150-4157.
[4]刘峰, 陈冬, 贤少忠, 等.腹腔镜下前列腺癌根治术与开放性手术的治疗效果对比分析[J].癌症进展, 2016, (3) :232-235.
[5]	[5]ROSENBERG S A, SPIESS P, LAFRENIERE R.A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes[J].Science, 1986, 233 (4770) :1318-1321.
[6]	[6]ADAMS S, GRAY R J, DEMARIA S, et al.Prognostic value of tumor-infiltrating lymphocytes in triplenegative breast cancers from two phase III randomized adjuvant breast cancer trials:ECOG 2197 and ECOG1199[J].J Clin Oncol, 2014, 32 (27) :2959-2966.
[7]	[7]BALERMPAS P, MICHEL Y, WAGENBLAST J, et al.Tumour-infiltrating lymphocytes predict response to definitive chemoradiotherapy in head and neck cancer[J].Br J Cancer, 2014, 110 (2) :501-509.
[8]	[8]AMATO R, STEPANKIW M, GONZALES P.A phase II trial of androgen deprivation therapy (ADT) plus chemotherapy as initial treatment for local failures or advanced prostate cancer[J].Cancer Chemother Pharmacol, 2013, 71 (6) :1629-1634.
[9]	[9]HELPAP B, RINGLI D, TONHAUSER J, et al.The significance of accurate determination of gleason score for therapeutic options and prognosis of prostate cancer[J].Pathol Oncol Res, 2016, 22 (2) :349-356.
[10]	[10]WILT T J, BRAWER M K, JONES K M, et al:Radical prostatectomy versus observation for localized prostate cancer[J].N Engl J Med, 2012, 367 (3) :203-213.
[11]	[11]WITZ I P.Yin-yang activities and vicious cycles in the tumor microenvironment[J].Cancer Res, 2008, 68 (1) :9-13.
[12]	[12]LI H, FAN X, HOUGHTON J.Tumor microenvironment:the role of the tumor stroma in cancer[J].J Cell Biochem, 2007, 101 (4) :805-815.
[13]	[13]FRIDMAN W H, PAGES F, SAUTES-FRIDMAN C, et al.The immune contexture in human tumours:impact on clinical outcome[J].Nat Rev Cancer, 2012, 12 (4) :298-306.
[14]	[14]SATO E, OLSON S H, AHN J, et al.Intraepithelial CD8+tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer[J].Proc Natl Acad Sci USA, 2005, 102 (51) :18538-18543.
[15]	[15]FU J, XU D, LIU Z, et al.Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients[J].Gastroenterology, 2007, 132 (7) :2328-2339.
[16]	[16]ZHANG Y L, LI J, MO H Y, et al.Different subsets of tumor infiltrating lymphocytes correlate with NPC progression in different ways[J].Mol Cancer, 2010, 9 (1) :4.
[17]	[17]WU H, CHEN P, LIAO R, et al.Intratumoral regulatory T cells with higher prevalence and more suppressive activity in hepatocellular carcinoma patients[J].J Gastroenterol Hepatol, 2013, 28 (9) :1555-1564.
[18]	[18]CROCI D O, ZACARIAS FLUCK M F, RICO M J, et al.Dynamic cross-talk between tumor and immune cells in orchestrating the immunosuppressive network at the tumor microenvironment[J].Cancer Immunol Immunother, 2007, 56 (11) :1687-1700.

相关文章(20)

[1]	崔培林, 宋玉霞, 王雪娟. 血清及组织miR-205预测卵巢型子宫内膜异位症术后复发价值, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20241016
[2]	李骞, 冯朴琼, 姚勤, 陈寒梅, 赵婷, 吴晖. 阿司匹林单药抗血小板治疗的缺血性卒中患者复发危险因素分析, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20240113
[3]	王伟, 刘胜, 周红庆, 刘明生, 谢平波, 郭峰, 陈冠宇. 局部晚期前列腺癌即刻根治术的临床疗效研究, 昆明医科大学学报.
[4]	张权昌, 吴乔联, 刘宇, 赵欣. 腹腔镜与开腹完全结肠系膜切除术对结肠癌患者血小板活化、并发症发生率及肿瘤复发的影响, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230919
[5]	朱晓锋, 周广平, 王来藏, 周厚俊, 耿鑫, 余化霖, 李经辉, 白鹏. 复发脑胶质瘤再手术治疗的临床疗效, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220920
[6]	吴希兰, 沈红, 石素胜, 张智慧, 郭蕾, 王芳. PD-L1、BRAF^V600E、CD68蛋白表达及肿瘤浸润淋巴细胞在恶性黑色素瘤诊断中的意义, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220923
[7]	赵斌, 段元鹏, 张国颖, 毕城伟, 杨李波, 施致裕, 杨勇, 张建朋, 高婷. CircRNA EZH2通过调控miR-30c-5p促进前列腺癌细胞增殖和迁移, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220731
[8]	张明雄, 张小文. 胆管空肠吻合术后肝胆管结石复发的危险因素, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210937
[9]	孙健玮, 王剑松, 刘子超, 郑立民. PTEN基因调控Raf-1磷酸化对前列腺癌PC3细胞凋亡的影响, 昆明医科大学学报.
[10]	李珲, 平秦榕, 史云强, 王春晖, 杨洋, 胡礼炳, 毕晓方, 李健, 钟一鸣. 外周血CTCs与前列腺癌临床特征的相关性, 昆明医科大学学报.
[11]	赵斌, 李瑞乾, 张国颖, 雷永虹, 王启林, 刘志敏. 过表达miR-4328抑制前列腺癌细胞的增殖、迁移和上皮间质转化, 昆明医科大学学报.
[12]	李宏. 腹腔镜与开腹子宫肌瘤剔除术后肌瘤残留、复发及妊娠疗效的比较, 昆明医科大学学报.
[13]	马寅锐. 白介素-8在前列腺癌组织中表达的临床意义, 昆明医科大学学报.
[14]	沈红. 前列腺特异性膜抗原、α-甲基酰基辅酶A消旋酶在前列腺癌中的表达及其临床意义, 昆明医科大学学报.
[15]	张劲松. 根治性膀胱癌标本中肿瘤侵犯前列腺及精囊的病理学研究, 昆明医科大学学报.
[16]	雷静. MSCT灌注成像在前列腺癌诊断中的初步研究, 昆明医科大学学报.
[17]	杜雄. CgA 和 PCA3的表达在前列腺癌患者诊断中的应用研究, 昆明医科大学学报.
[18]	刘鹏杰. 内分泌治疗在89 SrCl2治疗前列腺癌骨转移中的作用, 昆明医科大学学报.
[19]	孙健玮. PTEN基因与前列腺癌, 昆明医科大学学报.
[20]	刘孝东. 姜黄素对PC-3前列腺癌细胞株生长抑制的体外实验研究, 昆明医科大学学报.