Abstract: Objective To investigate the effect of glucosidorum tripterygll totorum combined with prednisone acetate and hydroxychloroquine sulfate in the treatment of systemic lupus erythematosus (SLE) . Me thods Eighty-two patients with SLE were divided into the control group (n=41) and the observation group (n=41) by the random number table method. The control group was treated with prednisone acetate combined with hydroxychloroquine sulfate. On the basis of treatment for the control group, the observation group was treated with glucosidorum tripterygll totorum. Four weeks was taken as 1 course of treatment and they were given 3 courses of treatment. Curative effect and adverse drug reactions were evaluated. The SLE disease activity index score was to evaluate the degree of lupus before and after treatment. The levels of blood lipid indexes [triglycerides (TG) , total cholesterol ( TC) , high density lipoprotein cholesterol ( HDL-C) , low density lipoprotein cholesterol (LDL-C) ], complement C3, immunoglobulin G (Ig G) , anti-double stranded DNA (ds-DNA) , interleukin 8 (IL-8) and interleukin 10 (IL-10) were determined. Re s ults The effective rate of the observation group was higher than that of the control group (92.50% vs 73.17% ) , P < 0.05. After treatment, the SLE-DAI score, levels of TC, TG, LDL-C, Ig G, anti-ds-DNA, IL-10 and IL-8 in the observation group were lower than those in the control group while levels of HDL-C and complement C3 were higher than those in the control group (all P < 0.05) . There was no significant difference in the incidence of adverse drug reactions between the two groups (56.10% vs 43.90% ) , P > 0.05. Conclusion The application of glucosidorum tripterygll totorum combined with prednisone acetate and hydroxychloroquine sulfate in the treatment of SLE can reduce the inflammatory and blood lipid levels and regulate immune mechanism. The effect is exact and patients can tolerate.