脑梗死患者继发性癫痫发生情况及高危因素调查

杜蓉; 徐碧芝

脑梗死患者继发性癫痫发生情况及高危因素调查

杜蓉,
徐碧芝

攀枝花市中心医院神经科

基金项目:

基金：四川省卫生厅科研基金资助项目 (140041);

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出版历程
- 收稿日期: 2017-01-05

Investigation on the Secondary Epilepsy Occurrence of Patients with Cerebral Infarction and Its Risk Factors

Du Rong ,
Xu Bi Zhi

Funds:

基金：四川省卫生厅科研基金资助项目 (140041);

摘要

摘要: 目的观察脑梗死患者继发性癫痫的发生情况, 探讨影响患者继发性癫痫的高危因素.方法选择攀枝花市中心医院2016年4月至2017年8月确诊的脑梗死继发性癫痫患者84例为观察组, 同时选择同一时期脑梗死未发生癫痫的84例患者作为对照组.随访继发性癫痫发作的情况, 记录患者的一般资料、基础疾病、高血压分级、血电解质、病灶位置、病灶直径等, 筛选脑梗死继发性癫痫的危险因素, 分析继发性癫痫发生情况.结果 (1) 继发性癫痫患者发作类型:部分发作69例, 全面发作15例;发病时间:早发性60例, 迟发性24例; (2) 2组患者一般资料、基础疾病、病灶直径、高血压分级等数据比较, 差异无统计学意义 (P>0.05) , 2组患者病灶位置及病变具体位置构成、血电解质水平比较, 差异具有统计学意义 (P<0.05) , 非条件多因素Logistic回归分析结果显示:梗死部位累及皮质、颞叶、血清氯值与继发性癫痫的发生具有相关性 (P<0.05) ; (3) 多因素Logistic回归分析结果显示:梗死部位累及皮质 (OR=3.10, P=0.004, 95%CI=1.527.41) 、梗死位于颞叶 (OR=2.98, P=0.012, 95%CI=1.327.35) 、血清氯值 (OR=1.25, P=0.017, 95%CI=1.001.38) 是脑梗死继发性癫痫的高危因素.结论脑梗死继发性癫痫以部分发作和早发性发作最为常见, 梗死部位累及皮质、位于颞叶、血清氯值是脑梗死患者继发性癫痫的高危因素, 应采取必要的措施对继发性癫痫发生的高危因素进行干预, 提高患者的临床生命质量.
- 继发性癫痫 /
- 脑梗死 /
- 高危因素 /
- 累及皮质 /
- 血清氯值
Abstract: Objective To observe the incidence of secondary epilepsy in patients with cerebral infarction and explore the risk factors of secondary epilepsy. Me thods Eighty-four patients with secondary epilepsy diagnosed as cerebral infarction from April 2016 to August 2017 in our hospital were selected as the observation group, and 84 patients of cerebral infarction without epilepsy in the same period were selected as the control group. Follow-up of secondary epileptic seizures, the general information of patients, basic diseases, hypertension grade, blood electrolytes, lesion location, diameter of lesion were recorded, and the risk factors of secondary epilepsy in cerebral infarction were screened, and the status of secondary epilepsy were analyzed. Re s ults (1) The types of epilepsy in secondary epilepsy: partial seizure in 69 cases, complete attack in 15 cases; onset time: early onset in 60 cases, late in 24 cases. (2) There was no significant difference between the two groups in general information, underlying disease, lesion diameter and grade ofhypertension (P>0.05) . The differences statistically significento significance in the consist of lesion location and lesion specific location and blood electrolyte levels (P <0.05) .Unconditional multivariate logistic regression analysis showed thoao infarction involving the cortex, temporal lobe, and serum chloride value was correlated with the occurrence of secondary epilepsy (P<0.05) . (3) MultivariateLogistic regression analysis showed tthat infaretion involving the cortex (OR = 3.10, P = 0.004, 95% CI =1.52-7.41) , locating in the temporal lobe, (OR = 2.98, P = 0.012, 95% CI = 1.32-7.35) and serum chlorine (OR = 1.25, P = 0.017, 95% CI = 1.00-1.38) were the risk factors for secondary epilepsy in cerebral infarction.Conclusions Partial and early onset of seizures are the most common in cerebral infarction secondary epilepsy.Infarction involving the cortex, locating in the temporal lobe and serum chlorine are the risk factors for secondary epilepsy in patients with cerebral infarction. Necessary measures should be taken to intervene at high risk of secondary epilepsy and to improve the clinical quality of life of patients.
- Secondary epilepsy /
- Cerebral infarction /
- High risk factors /
- Involving in the cortex /
- Serum chloride

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参考文献(15)

[1]王建茹.100例中老年继发性癫痫的发作类型及病因[J].中风与神经疾病杂志, 2011, 21 (1) :82-83.
[2]刘国政.缺血性脑血管病的研究进展[J].实用心脑肺血管病杂志, 2013, 21 (8) :5-6.
[3]	[3]GILAD R.Management of seizures following a stroke:What are the options[J].Druge Aging, 2012, 29 (7) :533-538.
[4]丁巧丽.脑卒中后癫痫的临床分析96例[J].中国社区医师, 2013, 15 (9) :29-30.
[5]王彦廷.脑卒中继发性癫痫30例临床分析[J].中国实用神经疾病杂志, 2014, 17 (7) :99-100.
[6] 慕容洋洋, 江山, 苏宁.脑卒中继发性癫痫的临床治疗与进展性研究[J].中华内科杂志, 2015, 44 (3) :163-166.
[7]陈文军, 荣阳, 荣根满.急性脑梗死后早期继发性癫痫的临床分析[J].中外医学, 2011, 9 (29) :52-53.
[8]邓颉, 张月华, 刘晓燕.发作和癫痫分类框架相关术语和概念修订--国际抗癫痫联盟分类和术语委员会报告, 2005-2009年[J].中国实用儿科杂志, 2011, 26 (7) :505-511.
[9]张振强, 宋军营, 贾亚泉.缺血性脑血管疾病研究进展[J].河南大学学报 (医学版) , 2013, 31 (4) :312-317.
[10]沈惠芬, 徐玲芬, 赵红艳.老年脑卒中患者早发性癫痫的护理[J].解放军护理杂志, 2011, 28 (5) :60-61.
[11]郭宁, 叶春林, 毕春辉.2001年国际抗癫痫联盟关于癫痫分类建议的临床应用讨论[J].武警后勤学院学报 (医学版) , 2013, 22 (10) :893-895.
[12]吴立文, 邓施萍, 彭炳蔚.癫痫及癫痫综合症国际分类 (1989年) 的临床应用分析[J].中华神经科杂志, 2005, 38 (6) :370-372.
[13]	[13]HSU C J, WENG W C, PENG S S, et al.Early-onset seizures are correlated with late-onset seizures in children with arterial ischemic stroke[J].Stroke, 2014, 45 (4) :1161-1163.
[14]	[14]PROCACCIANTI G, ZANIBONI A, RONDELLI F, et al.Seizures in acute stroke:Incidence, risk factors and prognosis[J].Neuroepidemiology, 2012, 39 (1) :45-50.
[15]程海军.脑卒中后继发性癫痫82例临床分析[J].中西医结合心脑血管病杂志, 2014, 12 (4) :453-455.

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