云南省某地艾滋病抗病毒治疗脱失患者的调查
An investigation on the Dropout of Patients with HIV/AIDS Receiving Antiviral Therapy in an Area of Yunnan Province
-
摘要: 目的 调查云南省某地某地接受免费艾滋病抗病毒治疗患者脱失原因及其影响因素.方法 整理云南省某地2004年7月至2015年5月的艾滋病抗病毒治疗患者资料, 采用χ2检验, Logistic回归分析患者治疗过程中出现脱失的可能影响因素.结果 6 614例接受抗病毒治疗的艾滋病患者中, 540例患者由于各种原因在抗病毒治疗过程中脱失, 脱失率8.2%.艾滋病抗病毒治疗过程中脱失的主要类型为失访 (402例, 74.4%) , 停药 (138例, 25.6%) .婚姻状况为已婚或同居、通过静脉吸毒感染、入组治疗基线CD4细胞计数>500个/μL、接受治疗时间小于6个月等均增加患者治疗过程中脱失概率.结论 在艾滋病抗病毒治疗过程中应加强对吸毒人群、未婚/离异、CD4细胞计数>500个/μL和治疗时间在6月内人群应给予重视, 加强患者依从性教育和关怀, 减少脱失.Abstract: Objective To investigate the cause of dropout among people living with HIV/AIDS receiving free antiretroviral therapy (ART) in Yunnan province and its associated factors. Me thods Data of patients with HIV/AIDS receiving ART were collected from ART initiative in July 2004 to May 2015 in four counties of Yunnan Province. The possible factors influencing the patients' dropout during the treatment were analyzed by χ2 test and logistic regression analysis. Re s ults Among 6614 patients with HIV/AIDS receiving antiretroviral therapy older than 15 years old, 540 patients dropped out of ART for various reasons, accounting for 8.2%. Among 540 patients who dropped out from ART, 74.4% were lost to follow-up and 25.6% quitted ART but could be reached by health workers. The main factors of dropout during the ART included the baseline CD4 count above 500, being non-marital, intravenous drug using, and receiving treatment for less than 6 months. Conclus ion We should pay attention to patients addicted to drug, receiving treatment less than 6 months, being non-marital or divorced and with baseline CD4 count above 500 in order to reduce the dropout rate by strengthening compliance and giving more care.
-
Key words:
- AIDS /
- Antiviral therapy /
- Dropout
-
[1]李道平, 徐娟, 王春容.湖北省中学生预防艾滋病知识态度行为调查[J].中国艾滋病性病, 2012, 18 (5) :313-315. [2]向青青, 黄缅.接受ART HIV/AIDS病人的依从性影响因素及干预对策[J].中国艾滋病性病, 2013, 19 (3) :166-168. [3] [3]ZHANG F J, PAN J, YU L, et al, Current progress of China’s free ART program[J].Cell Res, 2005, 15 (11/12) :877-822. [4] [4]ZHOU J L, TANUMA J, CHAIWARITH R, et al.Loss to follow up in HIV-infected patients from Asia-Pacific region:Results from TAHOD[J].AIDS Res Treat, 2012, 2012 (1) :375217. [5] 王安绪.艾滋病患者终止抗病毒治疗原因分析[J].中国公共卫生, 2007, 23 (12) :1436. [6]邱月锋, 夏品苍.福建省艾滋病患者抗病毒治疗终止原因分析[J].中国预防医学杂志, 2015, 16 (1) :350001 [7]陈亚丹, 绳宇.艾滋病患者抗病毒药物治疗依从性的干预现状[J].中华护理杂志, 2010, 45 (4) :375-376. [8]李雷, 雷纪丽, 王卫民, 等.南阳市AIDS病人抗逆转录病毒治疗依从性影响因素的调查分析[J].中国艾滋病性病, 2005, 11 (1) :50-51. [9]王安绪.AIDS病人终止HAART原因分析[J].中国公共卫生, 2007, 23 (12) :1436-1437. [10] 李韩平, 刘伟, 刘海霞, 等.广西壮族自治区133例AIDS病人HAART效果评价[J].中华流行病学杂志, 2007, 28 (4) :338-342. [11]支玉红, 王水旺, 张世霞.农村成人艾滋病抗病毒治疗管理模式探讨[J].中国初级卫生保健, 2008, 22 (1) :77-78. [12]陆娟, 刘中夫, 马烨, 等.62例静脉吸毒艾滋病病人抗病毒治疗疗效观察[J].中国艾滋病性病, 2008, 14 (6) :569-571. [13] [13]ZHU H, NAPRAVNIK S, ERON J, et al.Attrition among human immunodeficiency virus (HIV) -infected patients initiating antiretroviral therapy in China, 2003-2010[J].PLOS One, 2012, 7 (6) :e39414 [14] [14]BRINKHOF M W, DABIS F, MYER L, et al.Early loss of HIV-infected patients on potent antiretroviral therapy programmes in lower-income countries[J].Bull World Health Organ, 2008, 86 (7) :559-567. [15] [15]HACKER M A, KAIDA A, HOGG R S, et al.The first ten years:Achievements and challenges of the Brazilian program of universal access to HIV/AIDS comprehensive management and care, 1996-2006[J].Cad Saude Publica, 2007, 23 (Suppl 3) :S345-S359. [16] [16]OGUNTIBEJU O O.Quality of life of people living with HIV and AIDS and antiretroviral therapy[J].HIV AIDS (Auckl) , 2012, 4 (4) :117-124. [17]陆林.云南省艾滋病流行20年[J].昆明医科大学学报, 2013, 34 (6) :1-4. [18]周贵, 邓阳, 陈怡蓉, 等.HIV/AIDS患者在进行抗病毒治疗中的生命质量研究[J].昆明医科大学学报, 2013, 34 (7) :131-146.
点击查看大图
计量
- 文章访问数: 2876
- HTML全文浏览量: 903
- PDF下载量: 107
- 被引次数: 0