Abstract: Objective To explore the preventive measures through the analysis of the influential factors and the characteristics of human wounded based on the AIS (abbreviated injury scale) score to the occupant of the coach happened head-on collision. Me thods We adopted the accident investigation in-depth method and conducted statistical analysis and regression analysis of human wounded and related factors. Re s ults The person's gender had no significant difference on the AIS. The main body parts wounded were the head (AIS mean =3.7647) and the chest (AIS mean =4.000) , but no significant differences was shown in the t-test (t =-0.275, sig =0.785>0.05) ; The possibility of injury happened in the front three rows (AIS=4.750) was significantly higher than that of the average injury (AIS=1.706 (t=-4.819, Sig=0.000<0.05) happened in other rows; The seat fixed firmly with seatbelt can significantly reduce the occupant hurt. An analysis of variance showed that age, the seat row and the seat belt were the significant relative factors to the occupant hurt. The binomial logistic regression model showed that the death to the non-death probability ratio of the front two rows was up to 3 to 11 times.Conclus ion The significant factors affecting the degree of hurt are age, the seat rows and seat belt. The death to non-death probability ratio of the front two rows is too high, and the lap belt are not enough to protect the head and chest of the passengers. The front structure of the coach should be improved for the safety and the use of seatbelt should be encouraged while travelling.