特利加压素联合FK-409在大鼠减体积肝移植模型中对移植肝的保护作用

莽源祎; 李立; 冉江华; 张升宁; 刘静; 刘剑; 高杨; 李来邦

特利加压素联合FK-409在大鼠减体积肝移植模型中对移植肝的保护作用

昆明医科大学附属甘美医院昆明市第一人民医院肝胆一血管外科

基金项目:

基金：云南省科技厅昆明医科大学应用基础研究联合专项基金资助项目 (2010CD213);

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出版历程
- 收稿日期: 2017-12-19

The Effect of Terlipressin and FK-409 on Protection of Liver Graft Injury after Reduced-Size Liver Transplantation in Rats

Funds:

基金：云南省科技厅昆明医科大学应用基础研究联合专项基金资助项目 (2010CD213);

摘要

摘要: 目的在大鼠减体积肝移植模型中联合应用特利加压素和FK-409探究其对受体移植肝的保护作用.方法使用30%体积供肝行SD大鼠同系肝移植, 监测术后门静脉压力、血谷丙转氨酶 (ALT) 、总胆红素水平和术后生存时间, 构建有效的减体积肝移植模型.利用减体积肝移植模型作为载体, 根据不同的干预手段将受体大鼠分为特利加压素处理组、FK-409处理组、特利加压素处理联合FK-409处理组和对照组, 监测术后各组门静脉压力、血谷丙转氨酶 (ALT) 、总胆红素水平和术后生存时间, 统计并分析特利加压素处理联合FK-409处理对减体积肝移植移植肝的保护作用.结果在减体积肝移植模型中, 特利加压素联合FK-409处理组与对照组比较, 术后门静脉压力显著小于对照组, 差异有统计学意义 (P<0.05) , 术后血清ALT、总胆红素显著低于对照组, 差异有统计学意义 (P<0.05) , 术后生存时间较对照组明显延长, 差异有统计学意义 (P<0.05) , 在减体积肝移植模型中联合使用特利加压素、FK-409可有效保护移植肝脏.结论特利加压素联合FK-409可有效保护大鼠减体积肝移植中移植肝, 特利加压素联合FK-409方案可能成为减体积肝移植术后小肝综合症防治的潜在药物处理方案.
- 特利加压素 /
- FK-409 /
- 减体积肝移植
Abstract: Object To detect the effect of terlipressin and FK-409 on protection of liver graft injury after reduced-size liver transplantation in rats. Me thods We performed liver transplantation using 30% volume liver graft in rats. ALT, total bilirubin, portal vein pressure and survival rate were detected after operation. We divided recipient rats into four groups including terlipressin treatment group, FK-409 treatment group, terlipressin groups and FK-409 treatment group. ALT, total bilirubin, portal vein pressure and survival rate were detected in each group after operation. We compared results of four groups and found potential therapy which protected liver graft injury after reduced-size liver transplantation. Re s ults In reduced-size liver transplantation model, terlipressin and FK-409 treatment group showed lower portal vein pressure (P <0.05) , lower level of ALT and bilirubin (P<0.05) and longer survival time (P<0.05) compared with the control group. Using terlipressin and FK-409 could reduce liver graft injury after reduced-size liver transplantation. Conclus ion Using terlipressin and FK-409 could reduced liver graft injury, which might be the potential therapy for small-for-size syndrome after reduced-size liver transplantation.
- Terlipressin /
- FK-409 /
- Reduced-size liver transplantation

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参考文献(21)

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