IL1RN基因多态性与脑胶质瘤患病风险的相关性

李国林; 李超; 李峰

IL1RN基因多态性与脑胶质瘤患病风险的相关性

铜川矿务局中心医院神经外科

基金项目:

基金：陕西省科技攻关基金资助项目 (2016SF-110);

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出版历程
- 收稿日期: 2017-11-21

The Research of Correlation of Genetic Polymorphisms in IL1RN with Risk of Glioma

Funds:

基金：陕西省科技攻关基金资助项目 (2016SF-110);

摘要

摘要: 目的研究IL1RN基因多态性与脑胶质瘤患病风险的相关性.方法选择2012年1月至2016年12月于铜川矿务局中心医院就诊的符合入选条件的脑胶质瘤患者共200例, 以及健康对照人群200例, 分别采集血样.采用Mass ARRAY方法对rs17042888、rs315919、rs928940、rs3181052、rs452204和rs4252019六个位点的基因型进行测定, 用SPSS软件统计基因多态性与脑胶质瘤患病风险的相关性.结果比较各位点的等位基因频率, 发现IL1RN基因上的rs315919位点的等位基因“G”和rs4252019位点的等位基因“C”会显著降低脑胶质瘤的患病风险 (rs315919:OR=0.841, 95%CI为0.7120.993, P=0.041;rs4252019:OR=0.835, 95%CI为0.7070.987, P=0.034) .引入遗传模型后, rs315919位点在隐性模型下, 携带G/G基因型的个体脑胶质瘤患病风险显著降低, 是携带T/T和G/T基因型的0.75倍 (OR=0.75, 95%CI为0.520.96, P=0.026) ;rs4252019位点在显性模型下, 携带C/T和C/C基因型的个体脑胶质瘤患病风险显著降低, 是携带T/T基因型的0.76倍 (OR=0.76, 95%CI为0.590.97, P=0.025) .结论 IL1RN基因上rs315919和rs4252019两个位点与降低脑胶质瘤的患病风险具有相关性.
- 脑胶质瘤 /
- IL1RN /
- 单核苷酸多态性 /
- 关联分析
Abstract: Objective To investigate the association between single nucleotide polymorphisms (SNPs) in IL1 RN and risk of glioma. Me thods A total of 200 glioma patients and 200 healthy controls were enrolled in Kuangwu Hospital of Tongchuan from January 2012 to December 2016. Blood samples were collected. The genotypes of rs17042888, rs315919, rs928940, rs3181052, rs452204 and rs4252019 were genotyped by Mass ARRAY method, and the association between SNPs with glioma risk was evaluated using SPSS 19.0. Re s ults Comparing the allele frequencies of SNPs, we found the allele "G" of rs315919 and allele "C" of rs4252019 were significantly associated with decreased risk of glioma (rs315919: OR=0.841, 95%CI: 0.712-0.993, P=0.041;rs4252019:OR =0.835, 95% CI: 0.707-0.987, P =0.034) . In the genetic model analysis, we found that under recessive model, carries of G/G genotype of rs315919 have 0.75-fold reduced risk of glioma, compared with carries of T/T and G/T genotypes (OR=0.75, 95%CI: 0.52-0.96, P=0.026) . Under dominant model, carries of C/T and C/C genotypes of rs4252019 have 0.76-fold reduced risk of glioma, compared with carries of T/T genotype (OR=0.76, 95 %CI: 0.59-0.97, P=0.025) . Conclus ion The rs315919 and rs4252019 in IL1 RN were associated with decreased risk of glioma.
- IL1RN /
- Single nucleotide polymorphisms (SNP) /
- Association study /

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参考文献(23)

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