同种异体输血对食管癌患者手术预后的影响

梅礼军; 张宁; 陈葳

同种异体输血对食管癌患者手术预后的影响

1. 安康市中心医院输血科
2. 西安交通大学第一附属医院检验科

基金项目:

基金：陕西省自然科学基金资助项目 (2017JM8084);

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出版历程
- 收稿日期: 2017-12-08

The Effect of Allogenic Blood Transfusion on the Prognosis after Esophagectomy among Patients with Esophageal Cancer

Funds:

基金：陕西省自然科学基金资助项目 (2017JM8084);

摘要

摘要:
目的探索同种异体输血 (allogenic blood transfusion, ABT) 对食管癌患者手术预后的影响.方法回顾性收集2009年1月至2017年6月于安康市中心医院住院并首次行食管切除术的500例食管癌患者, 根据病例是否接受ABT, 将其分为观察组 (n=417) 和对照组 (n=83) , 收集患者性别、年龄、肿瘤浸润深度 (T分期) 、淋巴结转移 (N分期) 、远处转移、肿瘤分级、手术方式、ABT、复发等指标, 并定期进行随访.结果观察组和对照组在性别、年龄、肿瘤浸润深度、淋巴结转移、远处转移、和肿瘤分级方面无统计学差异 (P>0.05) ;而在手术方式和复发情况差异有统计学意义 (P<0.05) .多因素逻辑回归结果显示年龄、手术方式和ABT都是食管癌围手术期死亡的危险因素 (P<0.05) .其中, ABT与食管癌患者围手术期死亡率显著相关 (OR=3.0, 95%CI:1.45.6, P=0.03) .此外, ABT (-) 患者的总生存期比ABT (+) 患者更长 (P<0.05) .COX多因素回归分析结果显示, 肿瘤浸润程度、淋巴结转移、远处转移、手术方式和ABT都是影响食管癌患者总生存期的危险因素 (P<0.05) .其中, ABT与食管癌患者总生存期风险显著相关 (HR=2.4, 95%CI:1.63.7, P=0.001) .结论 ABT与食管癌患者围术期死亡率和总生存期之间存在相关性, 接受ABT的食管癌患者术后预后效果更差.
- 同种异体输血 /
- 食管癌 /
- 预后 /
- 总生存期
- Allogenic blood transfusion (ABT) /
- Esophageal cancer /
- Prognosis /
- Overall survival

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参考文献(23)

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