ASL患者血清及脑脊液中MIP-1α和VEGF浓度的检测及临床意义

李国林; 李超; 李峰

ASL患者血清及脑脊液中MIP-1α和VEGF浓度的检测及临床意义

铜川矿务局中心医院神经外科

基金项目:

基金：陕西省科技攻关基金资助项目 (2016SF-110);

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出版历程
- 收稿日期: 2018-01-21

Clinical Significance of MIP-1α and VEGF Levels in Serum and CSF of ALS Patients

Funds:

基金：陕西省科技攻关基金资助项目 (2016SF-110);

摘要

摘要: 目的检测肌萎缩侧索硬化症 (amyotrophic lateral sclerosis, ALS) 患者血清及脑脊液 (cerebrospinal fluid, CSF) 中巨噬细胞炎性蛋白-1α (macrophage inflammatory protein-1 alpha, MIP-1α) 和血管内皮生长因子 (vascular endothelial growth factor, VEGF) 浓度, 研究血清和CSF中MIP-1α和VEGF浓度与ALS的临床相关性.方法收集2012年1月至2015年6月期间在铜川市矿务局中心医院就诊的ALS患者80例和紧张性头痛患者67例, 采取其血清及脑脊液, 采用ELISA法测定血清及脑脊液中的MIP-1α和VEGF浓度.结果 ALS患者血清及脑脊液中MIP-1α浓度均明显高于对照组, 差异有统计学意义 (P<0.05) .ALS患者血清中VEGF浓度高于对照组, 差异有统计学意义 (P<0.05) , ALS患者脑脊液中VEGF浓度高于对照组, 差异无统计学意义 (P>0.05) .MIP-1α和VEGF浓度与ALS病程呈正相关性.长病程组的MIP-1α和VEGF浓度均大于短病程组 (P<0.05) .结论 MIP-1α和VEGF浓度升高可能表明在ALS代偿反应的激活, 这反映MIP-1α和VEGF参与了肌萎缩侧索硬化的病理生理过程.VEGF和MIP-1α是具有预测和评估ALS潜在危害的生物标志物.
- 肌萎缩侧索硬化 /
- 巨噬细胞炎性蛋白-1α /
- 血管内皮生长因子
Abstract: Objective Through the detection of MIP-1α and VEGF levels in serum and CSF of ALS patients, we evaluated the clinical value of MIP-1 and VEGF levels in ALS patients. Me thods A total of 80 patients with ALS were collected from Kuangwu Hospital of Tongchuanin from Jan, 2012 to Jun, 2015, and 67 patients with non-inflammation neurological diseases were chosen as control group. We obtained CSF and serum samples, and the MIP-1α and VEGF levels were measured by ELISA method. Re s ults The MIP-1α levels in serum and CSF of ALS patients were statistically and significantly higher than those in the control group (P<0.05) .The VEGF levels in serum of ALS patients were statistically and significantly higher than those in the control group (P<0.05) .The VEGF levels in CSF of ALS patients were not higher than those in the control group, statistically insignificant (P >0.05) .MIP-1 alpha and VEGF levels was positively correlated with ALS course. The MIP-1αand VEGF levels of the long duration group were greater than the short duration group (P <0.05) .Conclus ion The rising of MIP-1α and VEGF may indicate an activation of compensatory responses in ALS which suggested that MIP-1 alpha and VEGF are involved in the pathophysiology of amyotrophic lateral sclerosis. We propose that MIP-1α and VEGF may be a useful biomarker witha prognostic and evaluating potential for ALS.
- Amyotrophic lateral sclerosis /
- Macrophage inflammatory protein-1 alpha (MIP-1α) /
- Vascular endothelial growth factor

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参考文献(18)

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