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TDP-43与神经退行性疾病及脑损伤的相关性研究进展

蔡斌 宋海 王振 韩雪 于建云

蔡斌, 宋海, 王振, 韩雪, 于建云. TDP-43与神经退行性疾病及脑损伤的相关性研究进展[J]. 昆明医科大学学报, 2018, 39(05): 124-127.
引用本文: 蔡斌, 宋海, 王振, 韩雪, 于建云. TDP-43与神经退行性疾病及脑损伤的相关性研究进展[J]. 昆明医科大学学报, 2018, 39(05): 124-127.
Cai Bin , Song Hai , Wang Zhen , Han Xue , Yu Jian Yun . Research Progress of the Relationship of the Expression of TAR DNA/RNA-binding Domain Protein 43 in Neurodegenerative Disease and Brain Injury[J]. Journal of Kunming Medical University, 2018, 39(05): 124-127.
Citation: Cai Bin , Song Hai , Wang Zhen , Han Xue , Yu Jian Yun . Research Progress of the Relationship of the Expression of TAR DNA/RNA-binding Domain Protein 43 in Neurodegenerative Disease and Brain Injury[J]. Journal of Kunming Medical University, 2018, 39(05): 124-127.

TDP-43与神经退行性疾病及脑损伤的相关性研究进展

基金项目: 

基金: 国家自然科学基金资助项目 (81360467); 云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2013FB104);

Research Progress of the Relationship of the Expression of TAR DNA/RNA-binding Domain Protein 43 in Neurodegenerative Disease and Brain Injury

Funds: 

基金: 国家自然科学基金资助项目 (81360467); 云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2013FB104);

  • 摘要: TAR DNA/RNA结合蛋白43 (TARDNA/RNA-binding domain protein 43, TDP-43) 是一种高度保守、广泛表达的核蛋白.肌萎缩侧索硬化症 (amyotrophic lateral sclerosis, ALS) 、额颞叶变性 (frontotemporal lobar degeneration, FTLD) 、阿尔茨海默病 (alzheimer disease, AD) 等神经退行性疾病的病理学标记蛋白被公认是TDP-43.就TDP-43的结构、功能及其与神经退行性疾病之间的关系作一综述.同时在对TDP-43生物学特性认识的基础上, 探讨TDP-43在急、慢性颅脑损伤中的特殊表达与作用, 从而探索TDP-43在法医病理学中确定死亡原因、判定致伤致残情况的可行性.
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  • 收稿日期:  2017-09-10

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